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Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

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  1. Cat.No. Product Name Information
  2. A1910 Bromodomain Inhibitor, (+)-JQ1

    (+)-JQ1 is a BET bromodomain inhibitor, inhibits binding of a tetraacetylated the bromodomain 1/2 of BRD4 with IC50 of 77 nM and 33 nM, respectively.

  3. C4229 UMB-32
  4. C4097 NI-57
  5. C3668 GSK6853
  6. C3076 AZD 5153
  7. B7801 CPI-637
  8. B6197 PF-CBP1
  9. B6196 BI-7273
  10. B6184 BI-9564
  11. B6169 I-BRD9

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