Chromatin/Epigenetics
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Products for Chromatin/Epigenetics
- Bromodomain(41)
- Aurora Kinase(35)
- DNA Methyltransferase(14)
- HDAC(66)
- Histone Acetyltransferases(21)
- Histone Demethylases(33)
- Histone Methyltransferase(53)
- HIF(17)
- JAK(49)
- MBT Domains(1)
- PARP(35)
- Pim(13)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(26)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(2)
- PAD(1)
- Cat.No. Product Name Information
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B1256
AZ505 ditrifluoroacetate
SMYD2 inhibitor
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C3076
AZD 5153
orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4.
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A3214
AZD1152
Aurora B kinase inhibitor,highly potent and selective
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A3962
AZD1208
PIM kinase inhibitor
-
A4137
AZD1480
JAK2 inhibitor,ATP-competitive and novel
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A4164
AZD2461
Novel PARP inhibitor
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A4112
Barasertib (AZD1152-HQPA)
Aurora Kinase B inhibitor, Potent and selective
-
A3221
Bardoxolone methyl
IKK inhibitor, potent antioxidant inflammation modulator
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A4141
Baricitinib (LY3009104, INCB028050)
JAK1/JAK2 inhibitor,selective orally bioavailable
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A3222
Baricitinib phosphate
JAK1/JAK2 inhibitor
