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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

product-structure
  1. Cat.No. Product Name Information
  2. B1256 AZ505 ditrifluoroacetate SMYD2 inhibitor
  3. C3076 AZD 5153 orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4.
  4. A3214 AZD1152 Aurora B kinase inhibitor,highly potent and selective
  5. A3962 AZD1208 PIM kinase inhibitor
  6. A4137 AZD1480 JAK2 inhibitor,ATP-competitive and novel
  7. A4164 AZD2461 Novel PARP inhibitor
  8. A4112 Barasertib (AZD1152-HQPA) Aurora Kinase B inhibitor, Potent and selective
  9. A3221 Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator
  10. A4141 Baricitinib (LY3009104, INCB028050) JAK1/JAK2 inhibitor,selective orally bioavailable
  11. A3222 Baricitinib phosphate JAK1/JAK2 inhibitor

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