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Alzheimer

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

product-structure
  1. Cat.No. Product Name Information
  2. A1005 Beta-Sheet Breaker Peptide iAβ5 Peptide which can inhibit amyloidogenesis
  3. A1131 COG 133 ApoE mimetic peptide
  4. A8200 DAPT (GSI-IX) γ-secretase inhibitor,potent and specific
  5. A1031 Myelin Basic Protein (68-82), guinea pig Myelin Basic Protein
  6. A1040 Myelin Basic Protein (87-99) Encephalitogenic peptide
  7. A8190 Semagacestat (LY450139) γ-secretase inhibitor

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