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(R)-(+)-Atenolol
less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol.

Catalog No.C3031
Size Price Stock Qty
5mg
$136.00
In stock
10mg
$240.00
In stock
25mg
$526.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

(R)-(+)-Atenolol

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Chemical Properties

Cas No. 56715-13-0 SDF Download SDF
Chemical Name 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamide
Canonical SMILES NC(CC1=CC=C(OC[[email protected]](O)CNC(C)C)C=C1)=O
Formula C14H22N2O3 M.Wt 266.3
Solubility ≤5mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide Storage Store at -20°C
Physical Appearance A crystalline solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

(R)-(+)-Atenolol is the less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R, S)-atenolol [1].

Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. Atenolol is used for a number of conditions including hypertension, angina, long QT syndrome, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, and the symptoms of alcohol withdrawal. β1-adrenergic receptor is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.

Pharmacokinetic data of the time course of plasma concentrations over 24 h following oral administration of 50 mg (R)-(+)-Atenolol revealed that the Cmax, AUC, and t1/2 values were 326±87 ng/ml, 2599±639 ng×h/ml, and 8.9±2.9 h, respectively [1].

Reference:
[1] Stoschitzky K, Egginger G, Zernig G, et al.  Stereoselective features of (R)- and (S)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[J]. Chirality, 1993, 5(1): 15-19.