Toggle Nav

Pyroxamide

In stock
Catalog No.
A4497
HDAC1 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$58.00
In stock
10mg
$103.00
In stock
25mg
$245.00
In stock
50mg
$403.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Pyroxamide is an inhibitor of histone deacetylase [1].

Histone deacetylases (HADC) are a series of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone and make the histones to wrap the DNA more tightly, which prevent transcription.

In murine erythroleukemia (MEL) cells, pyroxamide induced terminal differentiation and inhibited cells growth by apoptosis or cell cycle arrest. Also, pyroxamide increased the levels of acetylated histones H2A, H2B, H3 and H4. Pyroxamide inhibited HDAC1 activity with ID50 value of 100 nM [1]. In RD (embryonal) and RH30B cell lines, pyroxamide (1.25-20.0 μM) induced apoptosis and accumulation of acetylated histones. Also, pyroxamide induced the expression of p21/WAF1 protein and increased the sub-G1 fraction [2].

In mice bearing human CWR22 prostate cancer xenograft, pyroxamide (100 or 200 mg/kg) significantly suppressed the growth of the tumor and increased the expression of p21/WAF1 protein in a dose-dependent way [1].

References:
[1].  Butler LM, Webb Y, Agus DB, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res, 2001, 7(4): 962-970.
[2].  Kutko MC, Glick RD, Butler LM, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. Clin Cancer Res, 2003, 9(15): 5749-5755.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt265.31
Cas No.382180-17-8
FormulaC13H19N3O3
SolubilitySoluble in DMSO
Chemical NameN'-hydroxy-N-pyridin-3-yloctanediamide
SDFDownload SDF
Canonical SMILESC1=CC(=CN=C1)NC(=O)CCCCCCC(=O)NO
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Pyroxamide