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Platelet Membrane Glycoprotein IIB Peptide (296-306)
Inhibits platelet aggregation

Catalog No.A1018
Size Price Stock Qty
1mg
$33.00
In stock
5mg
$99.00
In stock
10mg
$165.00
In stock
25mg
$231.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Platelet Membrane Glycoprotein IIB Peptide (296-306)

Platelet Membrane Glycoprotein IIB Peptide (296-306) Dilution Calculator

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Platelet Membrane Glycoprotein IIB Peptide (296-306) Molarity Calculator

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Chemical Properties

Cas No. SDF Download SDF
Synonyms H2N-Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu-OH
Canonical SMILES N[[email protected]@H]([[email protected]](C)O)C(N[[email protected]@H](CC(O)=O)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](CC(N)=O)C(NCC(N[[email protected]@H](CC(O)=O)C(NCC(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CC1=CNC=N1)C(N[[email protected]@H](CC(O)=O)C(N[[email protected]@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula C47H75N17O20 M.Wt 1198.2
Solubility >119.8mg/mL in DMSO or water Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Human alloantisera specific for either the Bak' or Bakb allele have been shown to react exclusively with the heavy chain of membrane glycoprotein (GP) Ilb.

GPllb is composed of a 125 Kd heavy chain that is disulfide-linked to a 23 Kd light chain. Hydropathicity analysis of the cDNA sequence indicates that GPllb is anchored to the platelet through a single transmembrane domain located within 20 amino acids of the C-terminus of the light chain.

The GPllb-IIa complex is a Ca2+-dependent heterodimer that, on activated platelets, can bind one of the four different adhesive proteins. (i.e. fibrinogen, fibronectin, von Willebrand factor, or vitronectin ).

Ref:

1. Bray PF, Rosa J-P, Lingappa VR, Kan YW, McEver RP, Shuman MA: Biogenesis of the platelet receptor for fibrinogen: Evidence for separate precursors for glycoproteins Ilb and IIIa. Proc Natl Acad Sci USA 83:1480,1986

2. Silver SM, McDonough MM, Vilaire G, Bennett JS: The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa. Blood 69:1031, 1987.

3. Phillips DR, Charo IF, Parise LV, Fitzgerald LA : The platelet membrane glycoproteins IIb-IIIa co,plex. Blood 71:831-843, 1988

A1018_1