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Pemetrexed

In stock
Catalog No.
A4390
TS, DHFR,GARFT and AICARFT inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
Evaluation Sample
$28.00
In stock
100mg
$50.00
In stock
200mg
$80.00
In stock

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Background

Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis. Pemetrexed is an analog of the classic antifolate GARFYT inhibitor lometroxol with a similar chemical structure, where the pyrazine ring in the pterine portion of folic acid and the benzylic nitrogen in the bridge portion of folic acid are replaced by a pyrrole ring and a methylene group respectively. Pemetrexed potently inhibits TS, DHFR, and GARFT as well as AICARFT but with a lesser potency and exhibits autitumor activity in a broad range of tumors, including non-small cell lung carcinoma, malignant mesothelioma, and carcinomas of the breast, colorectum, uterine cervix, head and neck, and bladder.

Reference

Luis Paz-Ares, Susana Bezares, Jose M. Tabernero, Daniel Castellanos, and Hernan Cortes-Funes. Review of a promising new agent-pemetrexed disodium. Cancer 2003; 97(8 Suppl):2056-2063

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt471.37
Cas No.150399-23-8
FormulaC20H19N5Na2O6
SynonymsPemetrexed disodium, Pemetrexed disodium heptahydrate, LY-231514, Pemetrexed Na
Solubility≥15mg/mL in DMSO, <2.11 mg/mL in EtOH, ≥30.67 mg/mL in H2O
Chemical Namedisodium;(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
SDFDownload SDF
Canonical SMILESC1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
Targets TS DHFR GARFT      
IC50 1.3 nM (Ki) 7.2 nM (Ki) 65 nM (Ki)      

Quality Control

Chemical structure

Pemetrexed

Related Biological Data

Pemetrexed

Related Biological Data

Pemetrexed

Related Biological Data

Pemetrexed