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PD 180970P210bcr/abl tyrosine kinase inhibitor

PD 180970

Catalog No. A8606
Size Price Stock Qty
10mg $241.00 Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

PD 180970

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Chemical Properties

Cas No. 287204-45-9 SDF Download SDF
Chemical Name 6-(2,6-dichlorophenyl)-2-(4-fluoro-3-methylanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one
Canonical SMILES CC1=C(C=CC(=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl)F
Formula C21H15Cl2FN4O M.Wt 429.27
Solubility Soluble in DMSO > 10 mM Storage Store at +4°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively).