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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Paroxetine Hydrochloride is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the
Cell lines
Splenic T cells
Reaction Conditions
0.1, 1 and 10 μM paroxetine
Applications
Paroxetine (1 μM and 10 μM) pretreatment distinctly restrained T cell migration induced by CX3CL1 through inhibiting G protein-coupled receptor kinase 2 (GRK2). Paroxetine also inhibited GRK2 induced activation of ERK. Thus, paroxetine could potentially attenuate the symptoms of collagen-induced arthritis due to its inhibitory effect on T cell activation and infiltration to synovial tissue via suppression of ERK pathway.
Animal models
Male CFY rats, 125 ~ 250 g
Dosage form
0.3, 1, 3 and 6 mg/kg
Oral administration
Paroxetine HCl dose-dependently prevented the 5-HT depleting effect of p-chloroamphetamine (PCA) in rat brain, demonstrating 5-HT uptake blockade in vivo. At the highest dose tested (6 mg/kg), paroxetine HCl completely prevented the PCA effect. Paroxetine HCl (0.3 and 6.0 mg/kg), administered in the absence of PCA, produced significant increases in brain 5-HT concentrations. Therefore, paroxetine HCl could provide a useful pharmacological tool for investigating 5-HT systems.
Note
The technical data provided above is for reference only.
References:
1. Wang Q, Wang L, Wu L, et al. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Scientific Reports, 2017, 7: 45364.
2. Thomas DR, Nelson DR, Johnson AM. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology (Berl), 1987, 93(2): 193-200.