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Parathyroid hormone (1-34) (human)
Increases blood calcium level

Parathyroid hormone (1-34) (human)

Catalog No. A1129
Size Price Stock Qty
1mg $100.00 In stock
5mg $300.00 In stock
10mg $500.00 In stock
25mg $700.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Parathyroid hormone (1-34) (human)

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Chemical Properties

Cas No. 52232-67-4 SDF N/A
Synonyms Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe
Canonical SMILES N/A
Formula C181H291N55O51S2 M.Wt 4117.75
Solubility Soluble to 0.40 mg/ml in sterile water Storage Desiccate at -20°C
General tips N/A
Shipping Condition N/A

Background

Parathyroid hormone (1-34) (human), (C181H291N55O51S2), a peptide with the sequence H2N-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 4117.72. Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor and the parathyroid hormone 2 receptor(1). Parathyroid hormone regulates serum calcium, It enhances the release of calcium from the large reservoir contained in the bones(2). It enhances active reabsorption of calcium and magnesium from distal tubules and the thick ascending limb(3). It enhances the absorption of calcium in the intestine by increasing the production of activated vitamin D.

A1129_1

Figure1  Formula of Parathyroid hormone (1-34) (human)

A1129_2

FigureThe parathyroid hormone (PTH) System

Ref:

1. Bieglmayer C, Prager G, Niederle B (October 2002). "Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy". Clin. Chem. 48 (10): 1731–8.

2. PooleK, Reeve J (2005). "Parathyroid hormone - a bone anabolic and catabolic agent". Curr Opin Pharmacol 5 (6): 612–7.

3. Coetzee M, Kruger MC (May 2004). "Osteoprotegerin-receptor activator of nuclear factor-kappaB ligand ratio: a new approach to osteoporosis treatment?". South. Med. J. 97 (5): 506–11.