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Catalog No.
H+/K+-ATPase inhibitor
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SizePriceStock Qty
10mM (in 1mL DMSO)
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In stock
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Pantoprazole is an inhibitor of H+/K+-ATPase [1].

Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively. Pantoprazole inhibited lysosomal acidification with IC50 value of 194 μM. The pKa values of pantoprazole are 3.83 (pKa1) and 0.11 (pKa2). Besides that, pantoprazole also shows antibacterial effects on Helicobacter pylori [1, 2].

[1] Jungnickel P W.  Pantoprazole: a new proton pump inhibitor. Clinical therapeutics, 2000, 22(11): 1268-1293.
[2] Sachs G, Shin J M, Howden C W.  Review article: the clinical pharmacology of proton pump inhibitors. Alimentary pharmacology & therapeutics, 2006, 23(s2): 2-8.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.102625-70-7
Solubility≥17.95mg/mL in DMSO
SDFDownload SDF
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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Chemical structure