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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cell lines
Macrophages
Preparation method
The solubility of this compound in H2O is ≥17.2mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
0-26nM
Applications
Olsalazine was a potent inhibitor of chemotaxis of LTB4 by macrophages with IC50 value of 0.39nM.
Animal models
Colorectal cancer tumor model in male rats
Dosage form
25 mg/kg/day(p.o.)
Application
In a rodent model with colon cancer, olsalazine effectively reduced the number and load of tumors, increased the rate of tumor apoptosis, and reduced the rate of tumor cell proliferation and inhibited tumor growth.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Kong D, Yun H, Cui D, Qi M, Shao C, Cui D, Ren N, Liang B, Wang A. Response of antimicrobial nitrofurazone-degrading biocathode communities to different cathode potentials. Bioresour Technol. 2017 Oct; 241:951-958. doi:10.1016/j.biortech.2017.06.056. Epub 2017 Jun 13. PubMed PMID: 28637162.
[2]. Brown WA, Farmer KC, Skinner SA, Malcontenti-Wilson C, Misajon A, O'Brien PE. 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci. 2000 Aug;45(8):1578-84. PubMed PMID: 11007109.