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Olprinone Hydrochloride

Catalog No.
Phosphodiesterase 3 (PDE3) inhibitor, selective
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Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.119615-63-3
SynonymsLoprinone (Hydrochloride)
Solubilityinsoluble in EtOH; ≥13.2 mg/mL in H2O with gentle warming; ≥52.1 mg/mL in DMSO with gentle warming
Chemical Name5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile;hydrochloride
SDFDownload SDF
Canonical SMILESCC1=C(C=C(C(=O)N1)C#N)C2=CN3C=CN=C3C=C2.Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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