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Catalog No.
metalloprotease inhibitor
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O-Phenanthroline is a membrane-permeable metal chelator, known as a non-specific matrix metalloproteinase (MMP) inhibitor [1].

Matrix metalloproteinases (MMPs) are zinc-dependent proteases involved in intra- and extra-cellular matrix remodeling resulting from an oxidative stress injury to the heart, of which MMP-2 increases during myocardial ischemia-reperfusion (I/R) injury-reduced oxidative stress, proteolyzing nuclear structural proteins.

In vitro proteolysis of lamins, which are the intermediate filament proteins providing support to the nuclear structural proteins and are targets of MMP-2, o-Phenanthroline abolished the proteolysis of lamin A [2].

The isolated rat hearts were subjected to ischemia-reperfusion (I/R) injury, of which treated with o-Phenanthroline had better left ventricular developed pressure and coronary flow during the reperfusion phase compared to those did not receive the drug [2].


[1] Georgi N, Landman E B M, Klein T J, et al. O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models [J]. J Tissue Eng Regen Med. 2017, 11(3): 724-732.

[2] Baghirova S, Hughes B G, Poirier M, et al. Nuclear matrix metalloproteinase-2 in the cardiomyocyte and the ischemic-reperfused heart [J]. J Mol Cell Cardiol. 2016, 94: 153-161.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.66-71-7
Solubilityinsoluble in H2O; ≥360.42 mg/mL in DMSO; ≥58.9 mg/mL in EtOH
Chemical Name1,10-phenanthroline
SDFDownload SDF
Canonical SMILESC(C=CC=N1)(C=C2)=C1C3=C2C=CC=N3
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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