NVP-BAG956|PI3K and PDK1 inhibitor|CAS# 853910-02-8

Size	Price	Stock	Qty
10mg	$252.00	In stock
50mg	$1,062.00	In stock

Publications citing ApexBio Products

Nature.
2017 Jan 19;541(7637):417-420.

Nature.
2018 Mar 29;555(7698):673-677.

Nature.
2017 Sep 7;549(7670):96-100.

Nature.
2016 Apr 21;532(7599):398-401.

Science.
2016 Aug 5;353(6299)594-8

Nat Nanotechnol.
2017 Dec;12(12):1190-1198.

Nature Biotechnology.
2017 Jun;35(6):569-576

Cell.
2018 Feb 22;172(5):1007-1021.e17.

Cell.
2017 Nov 30;171(6):1284-1300.e21.

Cell.
2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.
2017 Jul 13;170(2):312-323

Nat Med.
2018 Jan 29.

Nat Med.
2017 Nov;23(11):1342-1351.

Cell.
2017 Apr 6;169(2):286-300.

Cell.
2015 Aug 27;162(5):987-1002.

Cell.
2015 Feb 12;160(4):729-44.

Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2018 May 14;33(5):905-921.e5.

Cancer Cell.
2018 Apr 9;33(4):752-769.e8.

Cancer Cell.
2018 Mar 12;33(3):401-416.e8.

Cancer Cell.
2017 Aug 14;32(2):253-267.e5.

Cell Stem Cell.
2018 May 3;22(5):769-778.e4.

Cell Stem Cell.
2017 Nov 20. pii: S1934-5909(17)30375-2.

Cancer Cell.
2017 May 8;31(5):635-652.e6.

Immunity.
2018 Jan 16;48(1):59-74.e5.

Immunity.
2017 Oct 17;47(4):635-647.e6.

Immunity.
2016 Jan 19;44(1):88-102

Nat Cell Biol.
2018 Feb;20(2):186-197.

Nat Cell Biol.
2017 Dec 11.

Nat Cell Biol.
2015 May;17(5):627-38.

Nat Immunol.
2017 Jun;18(6):654-664.

Sci Transl Med.
2017 Dec 13;9(420). pii: eaal3765.

Quality Control

Quality Control & MSDS

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Purity = 98.00%

COA (Certificate Of Analysis)
MSDS (Material Safety Data Sheet)

Chemical structure

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Chemical Properties

Cas No.	853910-02-8	SDF	Download SDF
Synonyms	BAG 956
Chemical Name	2-methyl-2-(4-(2-methyl-8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
Canonical SMILES	CC1=NC2=CN=C3C=CC(C#CC4=CN=CC=C4)=CC3=C2N1C5=CC=C(C(C)(C#N)C)C=C5
Formula	C₂₈H₂₁N₅	M.Wt	427.5
Solubility	Soluble in DMSO > 10 mM	Storage	Store at -20°C
Physical Appearance	Red solid	Shipping Condition	Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

NVP-BAG956(BAG 956) is a potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in vivo,with IC50 values to be 56, 444, 34, 117 and 240 nM for PI3K p110 alpha, beta, delta and gamma and PDK1 kinases, respectively.