Home >> NG,NG-dimethyl-L-Arginine (hydrochloride)
Related Products
NG,NG-dimethyl-L-Arginine (hydrochloride)
endogenous nitric oxide synthase inhibitor

Catalog No.C5216
Size Price Stock Qty
25mg
$103.00
In stock
50mg
$182.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

      

Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

NG,NG-dimethyl-L-Arginine (hydrochloride)

NG,NG-dimethyl-L-Arginine (hydrochloride) Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

NG,NG-dimethyl-L-Arginine (hydrochloride) Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Chemical Properties

Cas No. 220805-22-1 SDF Download SDF
Synonyms ADMA
Chemical Name N5-[(dimethylamino)iminomethyl]-L-ornithine, dihydrochloride
Canonical SMILES OC(=O)[[email protected]@H](N)CCCNC(=N)N(C)C
Formula C8H18N4O2 • 2HCl M.Wt 275.2
Solubility ≤3.5mg/ml in ethanol;3.5mg/ml in DMSO;3.5mg/ml in dimethyl formamide Storage Store at -20°C
Physical Appearance A crystalline solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

NG,NG-dimethyl-L-Arginine is an endogenous nitric oxide synthase inhibitor.

Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence.

In vitro: NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].

In vivo: Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].

Clinical trial: Local infusion of ADMA into the brachial artery of healthy volunteers caused a dose-dependent fall in forearm blood-flow. Infusion of ADMA for 5 min resulted in a fall in forearm blood-flow in 5 subjects, and the effects of this ADMA dose were significantly attenuated by infusion of L-arginine [1].

Reference:
[1] Vallance, P. ,Leone, A.,Calver, A., et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339, 572-575 (1992).