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NG,NG-dimethyl-L-Arginine (hydrochloride)

Catalog No.
endogenous nitric oxide synthase inhibitor
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NG,NG-dimethyl-L-Arginine is an endogenous nitric oxide synthase inhibitor.

Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence.

In vitro: NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].

In vivo: Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].

Clinical trial: Local infusion of ADMA into the brachial artery of healthy volunteers caused a dose-dependent fall in forearm blood-flow. Infusion of ADMA for 5 min resulted in a fall in forearm blood-flow in 5 subjects, and the effects of this ADMA dose were significantly attenuated by infusion of L-arginine [1].

[1] Vallance, P. ,Leone, A.,Calver, A., et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339, 572-575 (1992).

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
Cas No.220805-22-1
Solubility≤3.5mg/ml in ethanol;3.5mg/ml in DMSO;3.5mg/ml in dimethyl formamide
Chemical NameN5-[(dimethylamino)iminomethyl]-L-ornithine, dihydrochloride
SDFDownload SDF
Canonical SMILESOC(=O)[[email protected]@H](N)CCCNC(=N)N(C)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

NG,NG-dimethyl-L-Arginine (hydrochloride)

Related Biological Data

NG,NG-dimethyl-L-Arginine (hydrochloride)