In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Nemadectin is a macrocyclic lactone antibiotic with a broad-spectrum endectocidal and nematocidal activity .
In dogs, oral administration of 0.2–0.4 mg/kg nemadectin (a liquid formulation administered in gelatin capsules) was effective in eliminating natural infections of Toxascaris leonina, Toxocara canis, Uncinaria stenocephala and Ancylostoma caninum. Tablets (267 mg) containing 4.6% nemadectin given at a rate of 13 tablet 0.2 mg/kg were active against A. caninum, T. canis, and U. stenocephala. With both formulations, an increase in the dose rate to 0.6-0.8 mg/kg led to 99-100% elimination of Trichuris vulpis infections. No adverse reactions were observed in any of the treated dogs .Oral administration of nemadectin to lambs infected with either a susceptible laboratory strain of Haemonchus contortus or a strain resistant to ivermectin reduced the nematode egg counts and the numbers of H contortus by 99% and 100% . Nemadectin has been used as starting material for the production of the veterinary anthelmintic, moxidectin, and these derivatives have been explored for their potential antiparasitic use .
 Doscher M E, Wood I B, Pankavich J A, et al. Efficacy of nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths[J]. Veterinary parasitology, 1989, 34(3): 255-259.
 Pankavich J A, Berger H, Simkins K L. Efficacy of moxidectin, nemadectin and ivermectin against an ivermectin-resistant strain of Haemonchus contortus in sheep[J]. The Veterinary Record, 1992, 130(12): 241-2, 243.
 Yang L Y, Wang J D, Zhang J, et al. New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3[J]. Bioorganic & medicinal chemistry letters, 2013, 23(20): 5710-5713.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||Soluble in ethanol;methanol;DMSO;dimethyl formamide|
|Chemical Name||(6R,23S)-5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-milbemycin B|
|Canonical SMILES||C/C(C[[email protected]@H](C)/C=C/C=C(CO1)/[[email protected]@]([[email protected]@]1([H])[[email protected]](O)C(C)=C2)(O)[[email protected]]2([H])C3=O)=C\C[[email protected]](O4)([H])C[[email protected]@](O3)([H])C[[email protected]]54O[[email protected]](/C(C)=C/C(C)C)[[email protected]@H](C)[[email protected]@H](O)C5|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|