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NAD+

Catalog No.
B1793
Coenzyme
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$50.00
In stock
1g
$62.00
In stock
5g
$143.00
In stock

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Email: [email protected]

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Background

NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is often used as a starting point for inhibitor design, a set of 14 analogs with natural NAD+ substrate can weakly inhibit NAD glycohydrolase (NADase) activity of CD38 (2 mM < IC50 < 10 mM) [1].

NAD+, also called nicotinamide adenine dinucleotide, act as a signaling molecule and a cofactor or substrate for enzymatic activities. 

NAD+ is an oxidizing agent which accepts electrons from other molecules and reduces to NADH [2]. NAD+ also plays important roles in the activity of several enzymes such as poly (ADP) – ribose polymerases and cADP – ribose synthases, it can be used by some sirtuins to participate in protein deacetylation mediation, which produce O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein [3].

Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia [4].

References:

[1]. Division of Biophysics, et al. NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry. Molecules 2019, 24(22), 4187.

[2]. Houtkooper RH1, Cantó C, Wanders R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 2010, 31(2), 194-223.

[3]. Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008, 7, 104-112.

[4]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH: ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt663.43
Cas No.53-84-9
FormulaC21H27N7O14P2
Solubility≥28.55mg/mL in H2O
Chemical Name[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
SDFDownload SDF
Canonical SMILESC1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C4N=CN=C5N)O)O)O)O)C(=O)N
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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