In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is often used as a starting point for inhibitor design, a set of 14 analogs with natural NAD+ substrate can weakly inhibit NAD glycohydrolase (NADase) activity of CD38 (2 mM < IC50 < 10 mM) .
NAD+, also called nicotinamide adenine dinucleotide, act as a signaling molecule and a cofactor or substrate for enzymatic activities.
NAD+ is an oxidizing agent which accepts electrons from other molecules and reduces to NADH . NAD+ also plays important roles in the activity of several enzymes such as poly (ADP) – ribose polymerases and cADP – ribose synthases, it can be used by some sirtuins to participate in protein deacetylation mediation, which produce O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein .
Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia .
. Division of Biophysics, et al. NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry. Molecules 2019, 24(22), 4187.
. Houtkooper RH1, Cantó C, Wanders R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 2010, 31(2), 194-223.
. Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008, 7, 104-112.
. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH: ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.
|Storage||Store at -20°C|
|Solubility||≥28.55 mg/mL in H2O; insoluble in EtOH; ≥26.05 mg/mL in DMSO|
|Chemical Name||[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|
Quality Control & MSDS
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