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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Monazomycin is a positively charged and polyenelike antibiotic produced by Streptomyces [1].
Monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. Monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. Application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. The steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. The major current-carrying ions were univalent cations. Monazomycin monomers cooperated to form a multimolecular conductance channel. The voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2].
References:[1] Bamberg E, Janko K. Single channel conductance at lipid bilayer membranes in presence of monazomycin[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1976, 426(3): 447-450.[2] Muller R U, Finkelstein A. Voltage-dependent conductance induced in thin lipid membranes by monazomycin[J]. The Journal of general physiology, 1972, 60(3): 263-284.