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MK-4827 tosylate

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Catalog No.
PARP1/PARP2 inhibitor
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MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
Cas No.1038915-73-9
SolubilitySoluble in DMSO
Chemical Name(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carbimidic acid compound with 4-methylbenzenesulfonic acid (1:1)
SDFDownload SDF
Canonical SMILESN=C(O)C1=CC=CC(C1=N2)=CN2C3=CC=C([[email protected]]4([H])CCCNC4)C=C3.CC5=CC=C(S(O)(=O)=O)C=C5
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

MK-4827 tosylate