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MK-4827 tosylatePARP1/PARP2 inhibitor

MK-4827 tosylate

Catalog No. B1164
Size Price Stock
1g Please Inquire Please Inquire

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

MK-4827 tosylate

MK-4827 tosylate Dilution Calculator

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Chemical Properties

Cas No. 1038915-73-9 SDF Download SDF
Chemical Name (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carbimidic acid compound with 4-methylbenzenesulfonic acid (1:1)
Canonical SMILES N=C(O)C1=CC=CC(C1=N2)=CN2C3=CC=C([C@]4([H])CCCNC4)C=C3.CC5=CC=C(S(O)(=O)=O)C=C5
Formula C26H28N4O4S M.Wt 492.59
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.