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ME0328

In stock
Catalog No.
A8808
PARP inhibitor,potent and selective
Grouped product items
SizePriceStock Qty
5mg
$76.00
In stock
10mg
$108.00
In stock
25mg
$233.00
In stock

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Background

ME0328 is a potent and selective inhibitor of PARP with IC50 value of 0.89 and 6.3 μM for PARP3 and PARP1, respectively [1].

Poly (ADP-ribose) polymerase (PARP) is a family of proteins mainly involved in programmed cell death and DNA repair. The overactivation of PARP may reduce the stores of cellular NAD+ and induce ATP depletion and cell death.

ME0328 is a potent and selective PARP inhibitor. ME0328 selectively inhibited ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3) with IC50 value of 0.89 μM and inhibited ARTD1 and ARTD2 with IC50 values of 6.3 and 10.8 μM, respectively. In human alveolar basal epithelial (A549) cells, treatment with ME0355 (10 μM) followed by γ-irradiation significantly delayed γH2AX-foci resolution in a concentration-dependent way, which suggested that ME0328 inhibited ARTD3 in cells. In nonirradiated human A549 and mouse MRC5 cells, ME0328 (10 μM) did not exhibit toxicity [1].

Reference:
[1].  Lindgren AE, Karlberg T, Thorsell AG, et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol, 2013, 8(8): 1698-1703.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt321.37
Cas No.1445251-22-8
FormulaC19H19N3O2
Solubility≥71.4mg/mL in DMSO
Chemical Name3-(4-oxo-1H-quinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide
SDFDownload SDF
Canonical SMILESCC(C1=CC=CC=C1)NC(=O)CCC2=NC(=O)C3=CC=CC=C3N2
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
Targets PARP3 PARP1        
IC50 0.89μM 6.3μM        

Quality Control

Quality Control & MSDS

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Chemical structure

ME0328