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Masitinib (AB1010)

potent and selective tyrosine kinase inhibitor

Masitinib (AB1010)

Catalog No. A2942
Size Price Stock Qty
5mg $50.00 In stock
25mg $100.00 In stock
100mg $300.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

Masitinib (AB1010)

Biological Activity

Description Masitinib is a potent and selective inhibitor of tyrosine kinases with IC50 values of 200 nM, 540 nM and 800 nM for KIT, PDGFRα and PDGFRβ, respectively.
Targets KIT PDGFRα PDGFRβ      
IC50 200 nM 540 nM 800 nM      

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Chemical Properties

Cas No. 790299-79-5 SDF Download SDF
Chemical Name 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
Canonical SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
Formula C28H30N6OS M.Wt 498.64
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Masitinib (AB1010) is a tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor with IC50 of 150 ± 80, 200 ± 40 nM for KIT tyrosine phosphorylation and the recombinant wild-type KIT. Masitinib can enhance the antiproliferative effects of gemcitabi