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LY2874455

LY2874455

Catalog No. A3576
Size Price Stock Qty
5mg $238.00 Ship Within 7 Days
10mg $428.00 Ship Within 7 Days
50mg $950.00 Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical structure

LY2874455

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Chemical Properties

Cas No. 1254473-64-7 SDF Download SDF
Synonyms LY 2874455; LY-2874455
Chemical Name 2-[4-[(E)-2-[5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Canonical SMILES CC(C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3C=CC4=CN(N=C4)CCO
Formula C21H19Cl2N5O2 M.Wt 444.31
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

LY2874455 is a novel and potent FGF/FGFR Inhibitor. LY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship.