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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cell lines
Dermatophytes, zygomycetes, filamentous fungi
Preparation method
The solubility of this compound in DMSO is ≥17.714 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
0.004~0.008 μg/ml
Applications
The results show that dermatophytes are most sensitive to Luliconazole (MIC ≤ 0.004~0.008 μg/ml). At low concentrations (MIC ≤ 0.004~0.125 μg/ml), Luliconazole inhibits all filamentous fungi except zygomycetes.
Animal models
Guinea pig
Dosage form
1% cream
Application
The results of the study showed that Luliconazole (1% cream) was slightly less effective than terbinafine. Luliconazole-treated guinea pigs have a small amount of conidial hair.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Uchida K, Nishiyama Y, Yamaguchi H. In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother.2004 Aug;10(4):216-9. PubMed PMID: 15365862.
[2]. Ghannoum MA, Long L, Kim HG, Cirino AJ, Miller AR, Mallefet P. Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model. Med Mycol. 2010 May;48(3):491-7. doi: 10.3109/13693780903373811. PubMed PMID: 20370362.