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KC7F2

Catalog No.
A4507
HIF-1α inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$63.00
In stock
10mg
$50.00
In stock
50mg
$200.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

KC7F2 is a novel inhibitor of HIF-1αwith IC50 value of 20 μM [1].

Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor consisting of α and β subunits. In normal situation, the HIF-1α subunit is constitutively translated, but rapidly degraded. While, under hypoxia it is stabilized. HIF target genes encode a series of critical factors to adapt the low oxygen [1].

In a HIF-reporter cell line LN229-HRE-AP, KC7F2 (>25 μM) reduced AP activity by 90% in LN229 cells, which indicated that KC7F2 inhibited AP enzyme activity. In LNZ308 human glioma cells, KC7F2 inhibited the expression of a panel of HIF target genes, such as matrix metalloproteinase 2 (MMP2), enolase 1, carbonic anhydrase IX (CA IX) and endothelin 1. Also, KC7F2 reduced expression of HIF-1α in a dose-dependent way [1].

In a rat epilepsy model, KC7F2 significantly shortened the latent period in the PTZ kindling model and increased the rate of spontaneous recurrent seizures during the chronic stage in the lithium-pilocarpine model [3].

References:
[1].  Narita T, Yin S, Gelin CF, et al. Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res, 2009, 15(19): 6128-6136.
[2].  Li J, Jiang G, Chen Y, et al. Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. Synapse, 2014, 68(9): 402-409.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt570.38
Cas No.927822-86-4
FormulaC16H16Cl4N2O4S4
Solubility≥24.95mg/mL in DMSO,insoluble in EtOH,insoluble in H2O
Chemical Name2,5-dichloro-N-[2-[2-[(2,5-dichlorophenyl)sulfonylamino]ethyldisulfanyl]ethyl]benzenesulfonamide
SDFDownload SDF
Canonical SMILESC1=CC(=C(C=C1Cl)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl)Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

KC7F2

Related Biological Data

KC7F2