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Catalog No.
Dopamine β-hydroxylase activator
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
In stock
In stock

Tel: +1-832-696-8203

Email: [email protected]

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It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Chemical Properties

StorageStore at -20°C
Cas No.4759-48-2
Solubilityinsoluble in H2O; ≥13.8 mg/mL in DMSO; ≥24.3 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
SDFDownload SDF
Canonical SMILESCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.


Cell experiment:[1]

Cell lines

Primary human sebocytes

Reaction Conditions

7 ~ 14 d incubation


Isotretinoin decreased sebocyte proliferation in a dose- and time-dependent manner, with IC50 values being 10 μM after a 7-d incubation and 1 μM after a 14-d incubation, respectively. Isotretinoin (8 d) also inhibited the synthesis of triglycerides, wax/stearyl esters and free fatty acids, and modulated keratin expression in primary human sebocytes at a concentration of 0.1 μM.

Animal experiment:[2]

Animal models

Male inbred Lewis (LEW, RT11) and Fisher (F344, RT11v1) rats, 200 ~ 220 g

Dosage form

2 mg/kg/day

Administered orally for 8 weeks


Isotretinoin reduced chronic rejection damage and decreased mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model. Thus, isotretinoin could serve as a potent immunosuppressive and anti-fibrotic agent able to prevent and inhibit progression of chronic allograft nephropathy.


The technical data provided above is for reference only.


1. Zouboulis CC, Korge B, Akamatsu H, et al. Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. Journal of Investigative Dermatology, 1991, 96(5): 792-797.

2. Adams J, Kiss E, Arroyo AB, et al. 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. The American Journal of Pathology, 2005, 167(1): 285-298.

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