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Ionomycin calcium salt

Catalog No.
B5165
ionophore
Grouped product items
SizePriceStock Qty
5mg
$88.00
Ship with 5-10 days
10mg
$158.00
Ship with 5-10 days

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Background

Ionomycin calcium salt is a calcium ionophore [1].

Ca2+ ionophore acts as a Ca2+ ionophore, allowing Ca2+ to cross cell membranes.

Ionomycin calcium salt is a calcium ionophore. In cultured chicken pectoralis muscle, ionomycin (10-6-10-5 M) selectively increased the incorporation of methionine into two proteins. Ionomycin increased influx of extracellular Ca2+ and increased Ca2+ concentration in the cytoplasm, which then regulated the synthesis of muscle proteins [2]. In rat parotid gland, ionomycin increased 86Rb efflux, 22Na uptake and 3H-protein secretion, which were dependent on increasing cytosolic Ca2+. In parotid cells, ionomycin released the receptor-regulated cellular Ca2+ pool [3]. In human bladder cancer cells HT1376, ionomycin significantly inhibited cell growth in a time- and dose-dependent way and induced apoptotic DNA degradation. Also, ionomycin reduced the ratios of Bcl-2 to Bax mRNA and protein [4].

In athymic nude mice bearing HT1376 tumors, ionomycin significantly inhibited tumor growth and reduced the tumorigenicity [4].

References:
[1].  Liu C, Hermann TE. Characterization of ionomycin as a calcium ionophore. J Biol Chem, 1978, 253(17): 5892-5894.
[2].  Roufa D, Wu FS, Martonosi AN. The effect of Ca2+ ionophores upon the synthesis of proteins in cultured skeletal muscle. Biochim Biophys Acta, 1981, 674(2): 225-237.
[3].  Poggioli J, Leslie BA, McKinney JS, et al. Actions of ionomycin in rat parotid gland. J Pharmacol Exp Ther, 1982, 221(1): 247-253.
[4].  Miyake H, Hara I, Yamanaka K, et al. Calcium ionophore, ionomycin inhibits growth of human bladder cancer cells both in vitro and in vivo with alteration of Bcl-2 and Bax expression levels. J Urol, 1999, 162(3 Pt 1): 916-921.

Chemical Properties

Physical AppearanceA crystalline solid
StorageDesiccate at -20°C
M.Wt747.08
Cas No.56092-82-1
FormulaC41H70O9·Ca
SolubilitySoluble in DMSO
Chemical Namecalcium (4S,6S,8S,10E,12R,14R,16E,18S,19S,20R,21S)-19,21-dihydroxy-22-((2R,2'R,5R,5'S)-5'-((R)-1-hydroxyethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
SDFDownload SDF
Canonical SMILESO[[email protected]](C)[[email protected]@]1(C)O[[email protected]](CC1)[[email protected]]2(C)O[[email protected]@H](C[[email protected]@H]([[email protected]@H](C)[[email protected]]([[email protected]](/C=C/C[[email protected]@H](C)C[[email protected]@H](C)/C([O-])=C\C([[email protected]@H](C)C[[email protected]@H](C)C[[email protected]@H](C)CCC([O-])=O)=O)C)O)O)CC2.[Ca+2]
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Ionomycin calcium salt