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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Indomethacin heptyl ester is a potent and selective COX-2 inhibitor with IC50 value of 0.04 μM [1].
The key step in thromboxane and prostaglandin biosynthesis involves the conversion of arachidonic acid to prostaglandin H2 (PGH2), a reaction catalyzed by the cyclooxygenase (COX) and peroxidase activities of prostaglandin endoperoxide synthase or cyclooxygenase. COX is composed of COX-1 and COX-2. COX-2 plays important role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system [1].
Indomethacin is a potent COX-1 and COX-2 inhibitor with IC50 value of 0.05 μM and 0.75 μM, and is also a nonsteroidal antiinflammatory drug. Indomethacin is a substituted indole acetic acid and many of the structurally diverse indomethacin esters and amides show enhanced selectivity for the COX-2 isoform. Indomethacin heptyl ester was more potent and selective COX-2 inhibitor with IC50 value of 0.04 μM and >66 μM for human recombinant COX-2 and COX-1, respectively [1].
Reference:[1]. Kalgutkar AS, Marnett AB, Crews BC, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem. 2000 Jul 27;43(15):2860-70.