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IKK-3 Inhibitor

Catalog No.
A3486
IKK-3 Inhibitor
Grouped product items
SizePriceStock Qty
1mg
$299.00
Ship with 10-15 days
5mg
$914.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

An IKK-3 Inhibitor. The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt469.53
Cas No.862812-98-4
FormulaC22H19N3O5S2
SolubilitySoluble in DMSO
Chemical Name5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-((2-(methylsulfonyl)benzyl)oxy)thiophene-2-carbonitrile
SDFDownload SDF
Canonical SMILESCOC1=C(OC)C=C2C(N=CN2C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)=C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

IKK-3 Inhibitor