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HS-173

Catalog No.
B4492
novel PI3K inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$90.00
In stock
5mg
$67.00
In stock
25mg
$238.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

Phosphatidylinositol 3-kinase (PI3K) was first identified over 20 years ago as a lipid kinase associated with viral oncoproteins. PI3K signaling pathway regulates various cellular processes such as growth, cell cycle progression, apoptosis, migration, metabolism, and cytoskeleton rearrangement. HS-173 is a novel PI3K inhibitor.

In vitro: HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G2/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1a and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro [1].

In vivo: HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. These results suggest that HS-173 has potent anti-angiogenic activity in vivo [1].

Clinical trials: Currenlty no clinical data are available.

Reference:
[1] Lee H, Jung KH, Jeong Y, Hong S, Hong SS.   HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. Cancer Lett. 2013 Jan 1;328(1):152-9.

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at -20°C
M.Wt422.46
Cas No.1276110-06-5
FormulaC21H18N4O4S
Solubility≥21.1mg/mL in DMSO
SDFDownload SDF
Canonical SMILESO=S(NC1=CN=CC(C(C=C2)=CN3C2=NC=C3C(OCC)=O)=C1)(C4=CC=CC=C4)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Biological Activity

Description HS-173 is a potent inhibitor of PI3Kα with IC50 value of 0.8 nM.
Targets PI3Kα          
IC50 0.8 nM          

Quality Control

Quality Control & MSDS

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Chemical structure

HS-173