Home >> HOAt
Related Products
HOAt
coupling activator for racemization-free coupling in peptide synthesis

Catalog No.A7024
Size Price Stock Qty
10mM (in 1mL DMSO)
$50.00
In stock
25g
$77.00
In stock
100g
$192.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

      

Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

HOAt

HOAt Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

HOAt Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Chemical Properties

Cas No. 39968-33-7 SDF Download SDF
Synonyms N/A
Chemical Name 3-hydroxytriazolo[4,5-b]pyridine
Canonical SMILES C1=CC2=C(N=C1)N(N=N2)O
Formula C5H4N4O M.Wt 136.11
Solubility >6.8mg/mL in DMSO Storage Desiccate at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

A coupling activator for racemization-free coupling in peptide synthesis; An additive for peptide segment coupling in in reducing the extent of configurational loss at the reactive carboxylic acid residue. Carpino L A etc. works demonstrated that the DIC/HOAt system is more effective in preserving configuration for peptide segment coupling than the analogous DIC/HOBt system

in DMF and DCM. [1]

Reference:
Carpino L A, El-Faham A.  The diisopropylcarbodiimide/1-hydroxy-7-azabenzotriazole system: segment coupling and stepwise peptide assembly[J]. Tetrahedron, 1999, 55(22): 6813-6830.