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GSK 2837808A

Catalog No.
B4929
Potent, selective lactate dehydrogenase A (LDHA) inhibitor
Grouped product items
SizePriceStock Qty
5mg
$198.00
Ship with 5-10 days
10mg
$350.00
Ship with 5-10 days
25mg
$744.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

GSK2837808A is a potent, selective lactate dehydrogenase A (LDHA) inhibitor (IC50 values are 1.9 and 14 nM for LDHA and LDHB respectively). 

In Snu398 but not HepG2 hepatocellular carcinoma cells. GSK2837808A (10 µM) reduces glucose consumption. 

After intravenous injection of GSK2837808A at 0.25 mg/kg in rats, the clearance is shown to be 69 mL/min/kg, which exceeds the blood flow of the animal liver. Oral administration of GSK2837808A at 50 mg/kg or 100 mg/kg in rats or mice, respectively, resulted in blood compound levels reaching or below the detection limit of 2.5 ng/mL. 

Reference:

[1]. Billiard J, Dennison J B, Briand J, et al. Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells. Cancer & Metabolism, 2013, 1(1): 19-19.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt649.62
Cas No.1445879-21-9
FormulaC31H25F2N5O7S
SolubilitySoluble in DMSO
Chemical Name3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid
SDFDownload SDF
Canonical SMILESO=S(C(C=N1)=C(NC2=CC(OC3=CC(F)=CC(F)=C3)=CC(C(O)=O)=C2)C(C1=C4)=CC=C4C5=CN=C(OC)N=C5OC)(NC6CC6)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

GSK 2837808A