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Go 6983

pan-PKC inhibitor

Go 6983

Catalog No. A8343
Size Price Stock Qty
1mg $69.00 In stock
10mg $146.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Go 6983

Biological Activity

Description Go 6983 is an inhibitor of pan-PKC with IC50 values of 7 nM, 7 nM, 6 nM and 10 nM for PKCα, PKCβ, PKCγ and PKCδ, respectively.
Targets PKCγ PKCα PKCβ PKCδ PKCζ PKCμ
IC50 6 nM 7 nM 7 nM 10 nM 60 nM 20 μM

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Chemical Properties

Cas No. 133053-19-7 SDF Download SDF
Synonyms Goe 6983;Go6983;Go-6983
Chemical Name 3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
Canonical SMILES CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
Formula C26H26N4O3 M.Wt 442.51
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.