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GAP-134 Gap junction modifier

Catalog No.A3430
Size Price Stock
5mg
$287.00
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10mg
$369.00
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50mg
$997.00
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200mg
$2,262.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

GAP-134

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Chemical Properties

Cas No. 943134-39-2 SDF Download SDF
Synonyms Danegaptide;ZP1609;GAP134;GAP 134;ZP-1609;ZP 1609
Chemical Name 1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid
Canonical SMILES O=C(O)C1N(C(CN)=O)CC(NC(C2=CC=CC=C2)=O)C1
Formula C14H17N3O4 M.Wt 291.3
Solubility DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). GAP-134 (Danegaptide), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. Gap junction modifier GAP-134, showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. GAP-134 is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.