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FR 180204ERK inhibitor

FR 180204

Catalog No. A8304
Size Price Stock Qty
10mM (in 1mL DMSO) $95.00 In stock
10mg $245.00 In stock
50mg $965.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

FR 180204

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Chemical Properties

Cas No. 865362-74-9 SDF Download SDF
Chemical Name 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine
Canonical SMILES C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=NN=C5C(=C4)C(=NN5)N
Formula C18H13N7 M.Wt 327.34
Solubility Soluble in DMSO > 10 mM Storage Store at +4°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1 μM).