Toggle Nav
Close
  • Menu
  • Setting

FR 180204

Catalog No.
A8304
ERK inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$95.00
In stock
10mg
$163.00
In stock
50mg
$692.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1 μM).

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt327.34
Cas No.865362-74-9
FormulaC18H13N7
Solubility≥10.25mg/mL in DMSO, ≥4.47 mg/mL in EtOH with ultrasonic,insoluble in H2O
Chemical Name5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine
SDFDownload SDF
Canonical SMILESC1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=NN=C5C(=C4)C(=NN5)N
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control