In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Fosinopril sodium is an effective inhibitor of angiotensin-converting enzyme (ACE) with IC50 value of 9nM .
Fosinopril is a third type ACE inhibitor with a phosphinic acid. It binds to the active site of ACE via targeting the zinc ions with its phosphinic acid moiety. Fosinopril is an orally active prodrug which is hydrolysed and converted to its active diacid fosinoprilat after oral administration. The absorption of fosinopril ranges between 18 and 41 %. Antacids can affect the absorption of fosinopril and cause a decrease in its bioavailability by increasing the gastric pH. The pharmacokinetics assay shows fosinopril is hydrolysed completely into fosinoprilat after absorption. And fosinoprilat is slowly eliminated by renal and hepatic clearance. Fosinopril is proved to produce sustained blood pressure reduction through improving systemic and renal haemodynamics and reducing left ventricular mass .
 Shionoiri H, Naruse M, Minamisawa K, Ueda S, Himeno H, Hiroto S, Takasaki I. Fosinopril. Clinical pharmacokinetics and clinical potential. Clin Pharmacokinet. 1997 Jun;32(6):460-80.
|Storage||Store at -20°C|
|Solubility||Soluble in DMSO|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|