Follistatin, human recombinant protein
Follistatin is a high-affinity activin-binding protein produced in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Follistatin acts as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). Follistatin also inhibits the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1.
The Human Follistatin cDNA encodes a 344 aa precursor protein with a 29 aa signal peptide. Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids including 36 cysteine residues.
|Gene ID:||10468||Accession #:||P19883|
|Alternate Names:||Human Follistatin, Follistatin, h-Follistatin, rh-Follistatin, recombinant human Follistatin, recombinant Follistatin, Follistatin.|
|Source:||Escherichia Coli.||M.Wt:||31.5 kDa|
|Appearance:||Lyophilized protein||Storage:||Store at -20°C|
|Formulation:||Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 75 mM NaCl.|
|Solubility:||Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.|
|Shipping Condition:||Gel pack.||Handling:||Centrifuge the vial prior to opening.|
|Usage:||For Research Use Only! Not to be used in humans.|
|Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells.|
|ED50:0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A.|
Quality Control & DataSheet
- View current batch:
Purity: ≥95%, by SDS-PAGE and HPLC.
Endotoxin Level:< 0.1 ng/μg