Fluvastatin Sodium
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Fluvastatin sodium is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase [1].
Fluvastatin is a drug used to treat patients with hypercholesterolaemia. It lowers serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) as well as the serum apolipoprotein B. It also increases high density lipoprotein cholesterol (HDL-C) levels and apolipoprotein A-I levels. In addition to these, fluvastatin has antiatherogenic, antithrombotic and antioxidant effects. In U937 human monocyte cells, fluvastatin reduces the expression of adhesion molecules thus reducing the interaction between monocytes and endothelial cells. Fluvastatin dose-dependently reduces the platelet aggregation in vitro. The administration of fluvastatin at dose of 40 mg/day to patients reduces platelet aggregation by 10 to 15% after 4 to 24 weeks. In patients with hypercholesterolaemia, fluvastatin 40 mg/day for 8 weeks can reduce copper-induced diene production in LDL-C isolated from these patients. It is also reported that, fluvastatin can inhibit the production of NO and decreases inflammatory angiogenesis induced by the sponge matrix [1, 2].
References:
[1] Langtry HD, Markham A. Fluvastatin. A Review of its Use in Lipid Disorders. Drugs. 1999 Apr;57(4):583-606.
[2] Fernanda A. Araujo, Monaliza A. Rocha, Luciano S. A. Capettini, Paula P. Campos, Monica A. N. D. Ferreira, Virginia S. Lemos1and Silvia P. Andrade. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012,121:422-430.
| Storage | Store at -20°C |
| M.Wt | 433.45 |
| Cas No. | 93957-55-2 |
| Formula | C24H25FNNaO4 |
| Solubility | ≥16.83 mg/mL in EtOH; ≥18.15 mg/mL in DMSO; ≥8.22 mg/mL in H2O |
| Chemical Name | sodium;7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+] |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. |
Quality Control & MSDS
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Chemical structure
