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Finasteride acetate5α-reductase inhibitor

Finasteride acetate

Catalog No. B1195
Size Price Stock
100mg $50.00 Please Inquire
200mg $80.00 Please Inquire

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

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Chemical structure

Finasteride acetate

Finasteride acetate Dilution Calculator

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Chemical Properties

Cas No. 222989-99-3 SDF Download SDF
Formula C25H40N2O4 M.Wt 432.6
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Finasteride acetate(MK-906,Proscar and Propecia) is a specific inhibitor of 5α-reductase and a drug of synthetic used in the benign prostatic hyperplasia (BPH) and the male pattern baldness (MPB) [1].

In vivo, Finasteride acetate (MK-906, Proscar and Propecia) has been reported to significant reduce the concentration of DHT in prostatic tissue without side effects in pharmacologic experiments in rats and dogs. In addition, Finasteride acetate has shown the inhibition of 5α-reductase activity resulted in significant inhibition of DHT levels. Finasteride acetate has also shown the effect on reducing prostate volume in clinical experiments [1]. Finasteride acetate has been revealed to have the function to inhibit glucuronyl transferase in vitro test using rat prostate tissue [2].

References:
[1] Stoner E.The clinical development of a 5 alpha-reductase inhibitor, finasteride. J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):375-8.
[2] Rittmaster RS1, Stoner E, Thompson DL, Nance D, Lasseter KC.Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men. J Androl. 1989 Jul-Aug;10(4):259-62.