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E-3810

potent and selective VEGF/FGF dual inhibitor

E-3810

Catalog No. A3378
Size Price Stock Qty
5mg $256.00 Ship Within 7 Days
10mg $462.00 Ship Within 7 Days
50mg $925.00 Ship Within 7 Days
200mg $2,468.00 Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

E-3810

Related Biological Data

E-3810

Biological Activity

Description E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively.
Targets VEGFR-1 VEGFR-2 VEGFR-3 FGFR-1 FGFR-2  
IC50 7 nM 25 nM 10 nM 17.5 nM 82.5 nM  

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Chemical Properties

Cas No. 1058137-23-7 SDF Download SDF
Synonyms E 3810; E3810
Chemical Name 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide
Canonical SMILES CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
Formula C26H25N3O4 M.Wt 443.49
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

E-3810, a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.