Untitled Document
  ChemDraw06111413572D

 36 40  0  0  0  0  0  0  0  0999 V2000
   -1.7697    0.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7697    0.0878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0552   -0.3247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3407    0.0878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3407    0.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0552    1.3253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4841    1.3253    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1986    0.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9131    1.3253    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6276    0.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1986    0.0878    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3737   -0.3247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3737   -1.1497    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0882   -1.5622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8027   -1.1497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8027   -0.3247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0882    0.0878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5873   -1.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0722   -0.7372    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5873   -0.0697    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0882   -2.3872    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3737   -2.7997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3737   -3.6247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0882   -4.0372    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8027   -3.6247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8027   -2.7997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8422    0.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6492    0.8864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9042    1.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3521    2.2841    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5451    2.1126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2902    1.3280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6071    3.0688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0550    3.6818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4140    3.2403    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6276    4.0372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  1  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
  8 11  2  0      
  4 12  1  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 12  2  0      
 15 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 16  1  0      
 14 21  1  0      
 21 22  1  0      
 22 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 21  1  0      
 20 27  1  0      
 27 28  1  0      
 28 29  1  0      
 29 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 27  1  0      
 30 33  1  0      
 33 34  2  0      
 33 35  1  0      
 35 36  1  0      
M  END
>  <Catalog Number> (1)
A1266

>  <Item Name> (1)
WYE-354

>  <Formula> (1)
C24H29N7O5

>  <MolWeight> (1)
495.53

>  <CAS Number> (1)
1062169-56-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A1266

$$$$

Untitled Document
  ChemDraw07021413502D
 30 33  0  0  0  0  0  0  0  0999 V2000
   -1.9323   -2.8566    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6129   -0.5713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9115    0.5713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3662    1.3331    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0468   -0.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2726    0.5713    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0259    2.4757    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9115    1.2043    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454    2.4757    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0468    0.5713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0468    1.3331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7065    0.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3662    0.5713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7065    1.7140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6129    0.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0259    1.7140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9323    0.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6856    1.3331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5920    0.5713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9323   -0.5713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454    1.7140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8440    0.5880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2517    0.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2726   -0.9522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5920   -0.9522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6856    2.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6016    0.5083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2726   -1.7140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5920   -1.7140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9323   -2.0949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 30  1  0      
  2 15  2  0      
  3 23  1  0      
  4 13  1  0      
  4 14  1  0      
  4 16  1  0      
  5 10  1  0      
  6 15  1  0      
 17  6  1  6      
 16  7  2  0      
  7 26  1  0      
 21  8  1  0      
  8 27  1  0      
  9 21  1  0      
 26  9  2  0      
 10 11  1  0      
 12 10  1  0      
 10 15  1  0      
 11 14  1  0      
 13 12  1  0      
 16 18  1  0      
 17 19  1  0      
 17 20  1  0      
 21 18  2  0      
 22 18  1  0      
 19 23  1  0      
 20 24  1  0      
 20 25  2  0      
 27 22  2  0      
 24 28  2  0      
 29 25  1  0      
 28 30  1  0      
 30 29  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
M  END
>  <Catalog Number> (1)
A1387

>  <Item Name> (1)
AZD5363

>  <Formula> (1)
C21H25ClN6O2

>  <MolWeight> (1)
428.92

>  <CAS Number> (1)
1143532-39-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A1387

$$$$

Untitled Document
  ChemDraw03172015272D
 32 33  0  0  0  0  0  0  0  0999 V2000
    0.3560    1.6514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3560    0.8235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0729    0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7898    0.8235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7898    1.6514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0729    2.0653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0729    2.8903    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5042    0.4110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3584    0.4110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3584    3.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2187    0.8235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0729    0.8235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3584    2.0639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0729    1.6514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7874    2.0639    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5018    1.6514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3727    2.6492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2020    2.6492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5018    0.8264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2187    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2187   -0.4153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5018   -0.8292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7849   -0.4153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7849    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5018   -1.6542    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2163   -2.0667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0704   -0.8278    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0704   -1.6528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3560   -2.0653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3584   -1.6528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3560   -2.8902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3585   -3.3027    0.0000 Na  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  6  7  1  0      
  4  8  1  0      
  2  9  1  0      
  7 10  1  0      
  8 11  1  0      
  9 12  1  0      
  1 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  1  0      
 15 17  2  0      
 15 18  2  0      
 16 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 23  1  0      
 23 24  2  0      
 24 19  1  0      
 22 25  1  0      
 25 26  1  0      
 23 27  1  0      
 27 28  1  0      
 28 29  1  0      
 29 30  2  0      
 29 31  1  0      
 31 32  1  0      
M  STY  1   1 SUP
M  SLB  1   1   1
M  SAL   1  2  31  32
M  SBL   1  1  32
M  SMT   1 ONa
M  SBV   1  32    0.0000    0.8250
M  END
>  <Catalog Number> (1)
A1404

>  <Item Name> (1)
Rigosertib sodium salt

>  <Formula> (1)
C21H24NNaO8S

>  <MolWeight> (1)
473.47

>  <CAS Number> (1)
1225497-78-8

>  <Target> (1)
Cell Cycle/Checkpoint

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A1404

$$$$

Untitled Document
  ChemDraw02182016052D
 33 37  0  0  1  0  0  0  0  0999 V2000
    0.5834    1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1709    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5834    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4084    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8209    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4084    1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1709   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8209    2.5006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6459    2.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0584    3.2151    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0584    1.7862    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8834    3.2151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2959    3.9296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6541   -0.3572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0666   -1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6541   -1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1709   -1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5834   -1.0717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8916   -1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3041   -1.7862    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8916   -2.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0666   -2.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5834   -2.5006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1709   -3.2151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5834   -3.9296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4084   -3.9296    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8209   -3.2151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4084   -2.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6541   -3.2151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1291   -1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125   -1.2028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2959   -1.7862    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125   -2.3695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  3  7  1  0      
  6  8  1  0      
  8  9  1  0      
  9 10  1  0      
  9 11  2  0      
 10 12  1  0      
 12 13  1  0      
  7 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18  7  2  0      
 15 19  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 16  1  0      
 17 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 28  1  0      
 28 23  1  0      
 24 29  1  6      
 20 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 33  1  0      
 33 30  1  0      
V    1 2
V    2 3
V    3 4
V    4 5
V    5 6
V    6 1
V    7 2
V   12 1
V   13 2
V   14 1
V   15 8a
V   16 4a
V   17 4
V   18 3
V   19 8
V   20 7
V   21 6
V   22 5
V   23 4
V   24 3
V   25 2
V   26 1
V   27 6
V   28 5
V   30 3
V   31 2
V   32 1
V   33 4
M  END
>  <Catalog Number> (1)
A1642

>  <Item Name> (1)
GDC-0349

>  <Formula> (1)
C24H32N6O3

>  <MolWeight> (1)
452.55

>  <CAS Number> (1)
1207360-89-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A1642

$$$$

Untitled Document
  ChemDraw02282009212D
 30 34  0  0  0  0  0  0  0  0999 V2000
   -2.1809    0.0593    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5354   -0.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7677   -0.1524    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6455    0.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2910    1.1773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1687    1.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4011    2.2953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2444    1.7815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1222    0.9656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1222   -0.6662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6455   -0.3641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7677    0.4518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5354    0.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6576    1.5698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1331    2.2066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5766    2.9022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3752    2.6954    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4253    1.8719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0708    1.3581    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9486    0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1809    0.2401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2910   -0.8779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2444   -1.4821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0121   -1.7842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6576   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4253   -1.5725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0708   -1.0587    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.5475   -2.3884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9020   -2.9022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1343   -2.6001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  2  0      
  6  7  1  0      
  7  8  2  0      
  8  9  1  0      
  4  9  2  0      
  3 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  1  0      
 14 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  2  0      
 13 21  1  0      
 11 22  1  1      
 10 23  2  0      
 23 24  1  0      
 24 25  2  0      
  2 25  1  0      
 25 26  1  0      
 26 27  1  0      
 26 28  2  0      
 28 29  1  0      
 29 30  2  0      
 24 30  1  0      
M  END
>  <Catalog Number> (1)
A1720

>  <Item Name> (1)
IPI-145 (INK1197)

>  <Formula> (1)
C22H17ClN6O

>  <MolWeight> (1)
416.86

>  <CAS Number> (1)
1201438-56-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A1720

$$$$

Untitled Document
  ChemDraw03172016332D
 41 44  0  0  0  0  0  0  0  0999 V2000
   -3.9296    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9296   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9296    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9296    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9296   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9296   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    1.2375    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6956    2.1460    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  8 10  2  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 13 16  2  0      
 12 17  1  1      
 12 18  1  0      
 18 19  1  0      
 19 20  1  1      
 20 21  1  0      
 21 22  1  0      
 22 23  1  0      
 23 24  1  1      
 23 25  1  0      
 25 26  1  1      
 25 27  1  0      
 27 28  1  1      
 27 29  1  0      
 21 29  1  0      
 10 30  1  0      
 19 30  1  0      
 30 31  2  0      
 31 32  1  0      
  7 33  2  0      
 31 33  1  0      
 33 34  1  0      
  4 34  1  0      
 34 35  2  0      
  6 36  2  0      
  5 37  2  0      
 37 38  1  0      
 38 39  2  0      
  3 39  1  0      
 21 40  1  1      
M  END
>  <Catalog Number> (1)
A1832

>  <Item Name> (1)
Doxorubicin (Adriamycin) HCl

>  <Formula> (1)
C27H29NO11.HCl

>  <MolWeight> (1)
579.98

>  <CAS Number> (1)
25316-40-9

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A1832

$$$$

Untitled Document
  ChemDraw06111414122D
 30 34  0  0  0  0  0  0  0  0999 V2000
   -2.2019   -1.9524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2019   -2.7774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4874   -3.1899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7730   -2.7774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7730   -1.9524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4874   -1.5399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4874   -0.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0585   -1.5399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6560   -1.9524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3705   -1.5399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3705   -0.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6560   -0.3024    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0585   -0.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0849   -1.9524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7994   -1.5399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7994   -0.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0849   -0.3024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6560   -2.7774    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0849   -2.7774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7730   -0.3024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7730    0.5226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1055    1.0075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3605    1.7922    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1855    1.7922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4404    1.0075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7375    2.4053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5445    2.2337    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7994    1.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2474    0.8360    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4825    3.1899    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  6  7  1  0      
  5  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  2  0      
 11 12  1  0      
 12 13  2  0      
 13  8  1  0      
 10 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 11  1  0      
  9 18  2  0      
 14 19  1  0      
 13 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 23  2  0      
 23 24  1  0      
 24 25  2  0      
 25 21  1  0      
 24 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 29  2  0      
 29 25  1  0      
 26 30  1  0      
M  END
>  <Catalog Number> (1)
A2065

>  <Item Name> (1)
IC-87114

>  <Formula> (1)
C22H19N7O

>  <MolWeight> (1)
397.43

>  <CAS Number> (1)
371242-69-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2065

$$$$

Untitled Document
  ChemDraw02251418352D
 26 30  0  0  0  0  0  0  0  0999 V2000
   -0.5734    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5734   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1411   -1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8556   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8556    0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1411    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1411    1.4438    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8556    1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8556    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1411    3.0938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5734    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5734    1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3580    0.4612    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8429   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3580   -0.8737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6634   -0.2925    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9990   -1.0462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5140   -1.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6936   -1.6274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5700   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5700   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2845   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9990   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9990   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2845   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2845   -3.0938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12  7  1  0      
  1 13  1  0      
 13 14  1  0      
 14 15  2  0      
 15  2  1  0      
 14 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19 15  1  0      
  4 20  1  0      
 20 21  2  0      
 21 22  1  0      
 22 23  2  0      
 23 24  1  0      
 24 25  2  0      
 25 20  1  0      
 22 26  1  0      
M  END
>  <Catalog Number> (1)
A2067

>  <Item Name> (1)
PI-103

>  <Formula> (1)
C19H16N4O3

>  <MolWeight> (1)
348.36

>  <CAS Number> (1)
371935-74-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2067

$$$$

Untitled Document
  ChemDraw03182015162D
 28 29  0  0  0  0  0  0  0  0999 V2000
   -3.4558    2.6176    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6308    2.6185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2191    3.3334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3941    3.3342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2176    1.9044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3926    1.9053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9808    2.6202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1737    2.4495    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0866    1.6291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8399    1.2928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0106    0.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3969   -0.0658    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5676   -0.8729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0461   -1.4243    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5053   -2.0380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6598   -1.9757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4891   -2.7828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1028   -3.3342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8871   -3.0785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0578   -2.2713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8422   -2.0155    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.4558   -2.5669    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.0128   -1.2084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4441   -1.7199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2953   -3.0386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5975   -0.8106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3519   -1.1287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5968    0.6934    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  2  0      
  2  5  2  0      
  5  6  1  0      
  6  7  1  0      
  4  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
  6 10  1  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  1  0      
 14 15  2  0      
 14 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 21 23  2  0      
 20 24  2  0      
 16 24  1  0      
 17 25  1  0      
 14 26  2  0      
 13 27  1  0      
M  CHG  2  21   1  22  -1
M  END
>  <Catalog Number> (1)
A2080

>  <Item Name> (1)
PIK-75

>  <Formula> (1)
C16H14BrN5O4S.HCl

>  <MolWeight> (1)
488.74

>  <CAS Number> (1)
372196-77-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2080

$$$$

Untitled Document
  ChemDraw02251418052D
 26 28  0  0  0  0  0  0  0  0999 V2000
   -3.1633   -1.3168    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1633   -0.5259    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9541   -1.3168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1862    0.7378    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3954   -0.6319    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3725    0.0530    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1862   -2.0016    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3725   -1.3168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3725   -1.3168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7908   -1.3168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9771   -2.0016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9771   -0.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1862   -2.0016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1862   -0.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.3168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1633   -2.1076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1862   -0.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3954   -2.0016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5816   -1.3168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5816    0.0530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7679    0.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5587    0.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3725    1.4227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9541    1.4227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7679    2.1076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5587    2.1076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  1  3  2  0      
  1  9  1  0      
  1 16  1  0      
  4 20  2  0      
 15  5  2  0      
  5 17  1  0      
  6 20  1  0      
  6 21  1  0      
  7 18  2  0      
 19  7  1  0      
  8 19  1  0      
  9 11  1  0      
  9 12  2  0      
 13 10  1  0      
 10 14  2  0      
 10 15  1  0      
 11 13  2  0      
 14 12  1  0      
 15 18  1  0      
 17 19  2  0      
 17 20  1  0      
 21 22  1  0      
 21 23  2  0      
 22 24  2  0      
 25 23  1  0      
 24 26  1  0      
 26 25  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
M  END
>  <Catalog Number> (1)
A2521

>  <Item Name> (1)
VE-821

>  <Formula> (1)
C18H16N4O3S

>  <MolWeight> (1)
368.41

>  <CAS Number> (1)
1232410-49-9

>  <Target> (1)
Cell Cycle/Checkpoint

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2521

$$$$

Untitled Document
  ChemDraw03182015522D
 24 24  0  0  0  0  0  0  0  0999 V2000
    0.7397   -2.1417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3558   -1.4115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7962   -0.7139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6205   -0.7465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4122    0.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8526    0.7139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4686    1.4441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9090    2.1417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7333    2.1092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1737    2.8068    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1173    1.3790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9417    1.3464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6769    0.6813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4122    0.0489    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8526   -0.6488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6769   -0.6162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1173   -1.3138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9417   -1.2813    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7333   -2.0440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9090   -2.0766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5250   -2.8068    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4686   -1.3790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7538    1.3008    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3714    0.4533    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  1  0      
  3  5  2  0      
  5  6  1  0      
  6  7  2  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
  9 11  1  0      
 11 12  1  0      
 11 13  2  0      
  6 13  1  0      
  5 14  1  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  1  0      
 17 19  2  0      
 19 20  1  0      
 20 21  1  0      
 20 22  2  0      
  2 22  1  0      
 15 22  1  0      
M  END
>  <Catalog Number> (1)
A2552

>  <Item Name> (1)
Quercetin dihydrate

>  <Formula> (1)
C15H10O7.2H2O

>  <MolWeight> (1)
338.27

>  <CAS Number> (1)
6151-25-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2552

$$$$

Untitled Document
  ChemDraw06111414272D
 27 30  0  0  0  0  0  0  0  0999 V2000
    1.4289    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.8562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.8562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.0937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.6187    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.8563    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.6188    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.0937    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.6188    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  3  7  1  0      
  7  8  1  0      
  8  9  1  0      
  8 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 10  2  0      
 14 16  1  0      
 11 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 12  1  0      
 20 21  2  0      
 18 22  1  0      
 22 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 22  1  0      
M  END
>  <Catalog Number> (1)
A2681

>  <Item Name> (1)
TGX-221

>  <Formula> (1)
C21H24N4O2

>  <MolWeight> (1)
364.44

>  <CAS Number> (1)
663619-89-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2681

$$$$

Untitled Document
  ChemDraw06111414272D
 26 29  0  0  0  0  0  0  0  0999 V2000
    0.0782    0.1068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5052   -0.4766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2917   -1.2735    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5052   -1.4870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0886   -0.9037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8750   -0.1068    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7187   -2.2839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5156   -2.4974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0990   -1.9141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8855   -1.1172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1354    0.9037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3021   -0.2631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1354   -2.8673    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8959   -2.1276    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4480    1.4870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2345    2.2839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5624    2.4974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1458    1.9141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9323    1.1172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5156    0.5338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3125    0.7473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8959    0.1640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6823   -0.6329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8855   -0.8464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8178    2.8673    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5260    1.5442    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  2  0      
  4  7  2  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 10  5  2  0      
  1 11  1  0      
  2 12  1  0      
  7 13  1  0      
  9 14  1  0      
 11 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19 11  1  0      
 12 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 23  1  0      
 23 24  2  0      
 24 12  1  0      
 16 25  1  0      
 21 26  1  0      
M  END
>  <Catalog Number> (1)
A2754

>  <Item Name> (1)
TG100-115

>  <Formula> (1)
C18H14N6O2

>  <MolWeight> (1)
346.34

>  <CAS Number> (1)
677297-51-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2754

$$$$

Untitled Document
  ChemDraw06111414282D
 30 33  0  0  0  0  0  0  0  0999 V2000
    1.0101    3.3160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2956    2.9035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2956    2.0785    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0101    1.6660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7246    2.0785    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7246    2.9035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0101    4.1410    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.4189    3.3160    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1333    2.9035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8478    3.3160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5623    2.9035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0101    0.8410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7246    0.4285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7246   -0.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4390   -0.8090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1535   -0.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1535    0.4285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4390    0.8410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4390   -1.6340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1535   -2.0465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1535   -2.8715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8680   -1.6340    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4861   -3.3564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7410   -4.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5660   -4.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8209   -3.3564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3159    3.2391    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8680    2.6260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4555    1.9115    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6485    2.0830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  1  7  1  0      
  2  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
  4 12  1  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 13  1  0      
 15 19  1  0      
 19 20  1  0      
 20 21  1  0      
 20 22  2  0      
 21 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 21  1  0      
 11 27  1  0      
 27 28  1  0      
 28 29  2  0      
 29 30  1  0      
 30 11  2  0      
M  END
>  <Catalog Number> (1)
A2806

>  <Item Name> (1)
BX-912

>  <Formula> (1)
C20H23BrN8O

>  <MolWeight> (1)
471.35

>  <CAS Number> (1)
702674-56-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2806

$$$$

Untitled Document
  ChemDraw06111414292D
 34 38  0  0  0  0  0  0  0  0999 V2000
    0.2786    0.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2786   -0.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9931   -1.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7075   -0.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7075    0.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9931    0.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4220   -1.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1365   -0.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1365    0.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4220    0.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8510    0.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8510    1.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1365    1.7441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4220    1.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4359   -1.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1895   -0.8079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7416   -1.4210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3291   -2.1355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5221   -1.9639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6646   -2.8891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4851   -2.9754    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1797   -3.5566    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0771   -3.6036    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4031   -0.0110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8197    0.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0332    1.3692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8301    1.5828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135    0.9994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2000    0.2025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0436    2.3797    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8405    2.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0541    3.3901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4239    2.0098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8510    3.6036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  4  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
 10  5  1  0      
  9 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14 10  1  0      
  2 15  1  0      
 15 16  1  0      
 16 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 15  2  0      
 18 20  1  0      
 20 21  1  0      
 20 22  1  0      
 20 23  1  0      
 16 24  1  0      
 24 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 29  2  0      
 29 24  1  0      
 27 30  1  0      
 30 31  1  0      
 31 32  1  0      
 31 33  2  0      
 32 34  1  0      
M  END
>  <Catalog Number> (1)
A2846

>  <Item Name> (1)
OSU-03012 (AR-12)

>  <Formula> (1)
C26H19F3N4O

>  <MolWeight> (1)
460.45

>  <CAS Number> (1)
742112-33-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A2846

$$$$

Untitled Document
  ChemDraw02281418522D
 31 35  0  0  0  0  0  0  0  0999 V2000
   -2.8299    3.6813    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8936    3.6322    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0500    1.9764    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9873   -0.7797    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9122    0.3313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8930   -0.7905    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1157   -3.1649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6444   -4.0591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8366   -2.4463    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9935    0.3206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0437    0.8761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9495    0.8653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8998    2.5319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8559    1.9872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8621    0.8869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8992    0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0059    2.5212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9371   -1.3352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9308   -2.4355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8361    2.5811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8490    0.3042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9558    1.9656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0121    3.6215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8806   -2.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8363    2.0212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8428    0.8752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9118    2.5104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9682    4.1662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9180    3.6107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5558   -4.1662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8428   -1.3460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 20  1  0      
  2 13  2  0      
  3 11  1  0      
  3 13  1  0      
  3 17  1  0      
 10  4  1  0      
  4 18  1  0      
  5 11  2  0      
  5 15  1  0      
  6 18  2  0      
  6 31  1  0      
  7 19  1  0      
  7 30  2  0      
  8 24  1  0      
  8 30  1  0      
  9 24  1  0      
  9 31  2  0      
 10 11  1  0      
 10 12  1  6      
 12 16  1  0      
 13 14  1  0      
 14 15  2  0      
 14 20  1  0      
 15 21  1  0      
 17 22  2  0      
 17 23  1  0      
 18 19  1  0      
 19 24  2  0      
 20 25  2  0      
 21 26  2  0      
 22 27  1  0      
 23 28  2  0      
 25 26  1  0      
 27 29  2  0      
 28 29  1  0      
M  END
>  <Catalog Number> (1)
A3005

>  <Item Name> (1)
CAL-101 (Idelalisib, GS-1101)

>  <Formula> (1)
C22H18FN7O

>  <MolWeight> (1)
415.43

>  <CAS Number> (1)
870281-82-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3005

$$$$

Untitled Document
  ChemDraw02251418382D
 32 35  0  0  0  0  0  0  0  0999 V2000
   -1.0701   -1.9948    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.6253   -2.5724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3675    2.5724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7961    0.5052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3557    1.3300    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9568   -0.7320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2336    0.5103    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5193    1.3198    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9096   -1.2930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5193   -0.7372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2485   -2.0452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0688   -1.9567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2395   -1.1496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5163    0.0928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7932    1.3352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0789    0.0877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0730    1.7476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3586    0.5001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0969   -1.1247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3646    1.7424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0818    1.3249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8020    1.7374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9538    0.0979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0789    0.4950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2395    1.7323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3587    0.0826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7961    0.0775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9568    1.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2425    2.5622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3557   -0.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7932   -0.7524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0730   -1.1649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 32  1  0      
 12  2  1  6      
  3 20  2  0      
  4 14  1  0      
  4 15  1  0      
  4 16  1  0      
  5 17  1  0      
  5 18  1  0      
  5 20  1  0      
  6 13  1  0      
  6 23  2  0      
  7 14  2  0      
  7 23  1  0      
  8 22  1  0      
  8 25  1  0      
  9 10  1  0      
  9 11  1  0      
  9 19  1  1      
 10 13  2  0      
 10 14  1  0      
 11 12  1  0      
 12 13  1  0      
 15 17  1  0      
 16 18  1  0      
 20 21  1  0      
 21 22  1  1      
 21 24  1  0      
 24 26  2  0      
 24 27  1  0      
 25 28  1  0      
 25 29  1  0      
 26 30  1  0      
 27 31  2  0      
 30 32  2  0      
 31 32  1  0      
M  END
>  <Catalog Number> (1)
A3006

>  <Item Name> (1)
GDC-0068 (RG7440)

>  <Formula> (1)
C24H32ClN5O2

>  <MolWeight> (1)
458

>  <CAS Number> (1)
1001264-89-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3006

$$$$

Untitled Document
  ChemDraw03182016492D
 33 36  0  0  0  0  0  0  0  0999 V2000
   -2.4465   -1.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1359   -1.9454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3187   -2.0586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8121   -1.4074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1228   -0.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9400   -0.5300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0051   -1.5206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5117   -0.8694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2010   -0.1051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6162    0.0080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3289   -0.9826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8354   -0.3314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5248    0.4329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7076    0.5460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0314    1.0840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7208    1.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9036    1.9615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3970    1.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6395   -1.7468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4567   -1.8600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9633   -1.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6526   -0.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4961   -2.6877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9014   -3.2596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1738   -2.8708    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3082   -2.8326    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2274    2.4995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9874    2.1787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082    2.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5481    3.2596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4102    2.6126    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8564    0.7799    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8360    1.5574    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  2  0      
  4  7  2  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 10  5  2  0      
  8 11  1  0      
 11 12  2  0      
 13 14  2  0      
 14  9  1  0      
 13 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 14  1  0      
 11 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 12  1  0      
  2 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25  3  2  0      
 23 26  2  0      
 16 27  1  0      
 27 28  1  0      
 28 29  1  0      
 29 30  1  0      
 30 27  1  0      
 27 31  1  0      
M  END
>  <Catalog Number> (1)
A3010

>  <Item Name> (1)
MK-2206 dihydrochloride

>  <Formula> (1)
C25H21N5O.2HCl

>  <MolWeight> (1)
480.39

>  <CAS Number> (1)
1032350-13-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3010

$$$$

Untitled Document
  ChemDraw08041709182D
 32 35  0  0  0  0  0  0  0  0999 V2000
   -3.0101    2.6758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1180    3.4937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4637    3.9961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7014    3.6806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5935    2.8627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2478    2.3603    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8803    3.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6426    4.1247    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8312    2.5472    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7233    1.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0390    1.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1469    0.5959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9092    0.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0171   -0.5376    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7794   -0.8531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4338   -0.3507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3259    0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5636    0.7828    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1961   -0.6662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8994   -0.2349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5269   -0.7705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2114   -1.5328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3889   -1.4683    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6426   -2.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8873   -1.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2329   -2.1734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3408   -2.9913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1031   -3.3068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7575   -2.8044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6496   -1.9865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2110   -4.1247    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.4706   -1.8579    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  1  6  2  0      
  7  8  3  0      
  2  7  1  0      
 10 11  1  0      
 13 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 13 18  2  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 23  1  0      
 19 23  1  0      
 22 24  1  0      
 16 19  1  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 29  2  0      
 29 30  1  0      
 25 30  2  0      
 28 31  1  0      
 26 32  1  0      
 15 25  1  0      
 12 13  1  0      
 11 12  1  0      
  9 10  1  0      
  5  9  1  0      
M  END
>  <Catalog Number> (1)
A3011

>  <Item Name> (1)
CHIR-99021 (CT99021)

>  <Formula> (1)
C22H18Cl2N8

>  <MolWeight> (1)
465.34

>  <CAS Number> (1)
252917-06-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3011

$$$$

Untitled Document
  ChemDraw02251418402D
 29 32  0  0  0  0  0  0  0  0999 V2000
    2.5006   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -2.6813    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151   -2.6812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006    0.2063    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    0.6188    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    0.2063    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -1.4438    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -0.2063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -1.4438    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151   -2.2688    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -2.6813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    2.6813    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  1  6  2  0      
  1  7  1  0      
  8  9  1  0      
  8 10  1  0      
  8 11  1  0      
  3  8  1  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 12 17  2  0      
 18 19  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 23  1  0      
 18 23  1  0      
 16 18  1  0      
 24 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 28  1  0      
 28 29  1  0      
 24 29  1  0      
 12 24  1  0      
  4 14  1  0      
M  END
>  <Catalog Number> (1)
A3015

>  <Item Name> (1)
BKM120

>  <Formula> (1)
C18H21F3N6O2

>  <MolWeight> (1)
410.39

>  <CAS Number> (1)
944396-07-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3015

$$$$

Untitled Document
  ChemDraw02192011472D
 30 34  0  0  1  0  0  0  0  0999 V2000
   -3.2713    2.9927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0578    2.1958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2609    1.9823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6775    2.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8911    3.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6880    3.5761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8537    2.5225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5580    3.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1992    3.8119    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4412    1.8080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3838    1.8080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7963    1.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6213    1.0935    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0338    0.3791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7963    2.5225    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6213   -0.3354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0338   -1.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8588   -1.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2713   -0.3354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8588    0.3791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6213   -1.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7963   -1.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3838   -2.4788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7963   -3.1933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6213   -3.1933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0338   -2.4788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4131   -2.6923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4562   -3.5162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3140   -3.8119    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9964   -2.1090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  4  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9  5  1  0      
  7 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  1  0      
 11 15  1  6      
 14 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 20 14  1  0      
 17 21  1  0      
 21 22  2  0      
 22 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  2  0      
 26 21  1  0      
 23 27  2  0      
 27 28  1  0      
 28 29  1  0      
 29 24  2  0      
 27 30  1  0      
V    1 6
V    2 5
V    3 4
V    4 3a
V    5 7a
V    6 7
V    7 3
V    8 2
V    9 1
V   10 1
V   11 2
V   12 3
V   14 3
V   16 4
V   17 5
V   18 6
V   19 1
V   20 2
V   21 5
V   22 4
V   23 3a
V   24 7a
V   25 7
V   26 6
V   27 3
V   28 2
V   29 1
M  END
>  <Catalog Number> (1)
A3135

>  <Item Name> (1)
A-443654

>  <Formula> (1)
C24H23N5O

>  <MolWeight> (1)
397.48

>  <CAS Number> (1)
552325-16-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3135

$$$$

Untitled Document
  ChemDraw02192011572D
 42 49  0  0  0  0  0  0  0  0999 V2000
    0.1470    0.4678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5595   -0.2466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3845   -0.2466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7970    0.4678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3845    1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5595    1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1470   -0.9611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5595   -1.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3845   -1.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7970   -0.9611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7970   -2.3901    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6220   -2.3901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0345   -1.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6220   -0.9611    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0345   -3.1045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8595   -3.1045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2720   -2.3901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8595   -1.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6780   -0.9611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0905   -1.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6780   -2.3901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1470   -2.3901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4116   -3.7176    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1653   -3.3821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0790   -2.5616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1470    1.8968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6780    1.8968    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0905    1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0905    2.6112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9155    2.6112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3280    1.8968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9155    1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1530    1.8968    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7363    2.4801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4714    2.1056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3423    1.2907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5275    1.1617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1150    0.4472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7363    3.3051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4508    3.7176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1653    3.3051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1653    2.4801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  1  0      
 10  3  1  0      
  9 11  2  0      
 11 12  1  0      
 12 13  1  0      
 13 14  1  0      
 14 10  2  0      
 12 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 13  2  0      
  7 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22  8  1  0      
 16 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 17  1  0      
  6 26  1  0      
 26 27  1  0      
 27 28  1  0      
 27 29  1  0      
 29 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 28  1  0      
 31 33  1  0      
 33 34  1  0      
 34 35  1  0      
 35 36  1  0      
 36 37  1  0      
 37 33  1  0      
 37 38  2  0      
 34 39  2  0      
 39 40  1  0      
 40 41  2  0      
 41 42  1  0      
 42 35  2  0      
V    1 2
V    2 3
V    3 4
V    4 5
V    5 6
V    6 1
V    7 2
V    8 1
V    9 6
V   10 7
V   11 5
V   12 4a
V   13 8a
V   14 8
V   15 4
V   16 3a
V   17 9a
V   18 9
V   19 3
V   20 4
V   21 5
V   22 6
V   23 3
V   24 2
V   25 1
V   27 1
V   28 2
V   29 6
V   30 5
V   31 4
V   32 3
V   33 1
V   34 7a
V   35 3a
V   36 3
V   37 2
V   39 7
V   40 6
V   41 5
V   42 4
M  END
>  <Catalog Number> (1)
A3149

>  <Item Name> (1)
AKT inhibitor VIII

>  <Formula> (1)
C34H29N7O

>  <MolWeight> (1)
551.64

>  <CAS Number> (1)
612847-09-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3149

$$$$

Untitled Document
  ChemDraw02192013232D
 21 22  0  0  0  0  0  0  0  0999 V2000
   -1.0491    1.1563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5898    2.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2529    2.7010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1220    2.2862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9960    1.3315    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6938    0.4117    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1287    0.3472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4841   -0.3973    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5958    1.0273    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3065   -0.4618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6618   -1.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4843   -1.2708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8397   -2.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3726   -2.6953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5501   -2.6308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1947   -1.8863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7279   -3.4399    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5504   -3.5044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8470    2.6797    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.8688    3.5044    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5504    2.2484    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
 19 20  2  0      
 19 21  1  0      
  4 19  1  0      
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  1  1  0      
  1  6  1  0      
  6  7  1  0      
  7  8  1  0      
  7  9  2  0      
  8 10  1  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 11  1  0      
 14 17  1  0      
 17 18  1  0      
M  CHG  2  19   1  21  -1
V    1 2
V    2 3
V    3 4
V    4 5
V    5 1
V   11 1
V   12 2
V   13 3
V   14 4
V   15 5
V   16 6
M  STY  1   1 SUP
M  SLB  1   1   1
M  SAL   1  3  19  20  21
M  SBL   1  1   3
M  SMT   1 NO2
M  SBV   1   3    0.7251   -0.3935
M  END
>  <Catalog Number> (1)
A3184

>  <Item Name> (1)
AR-A014418

>  <Formula> (1)
C12H12N4O4S

>  <MolWeight> (1)
308.31

>  <CAS Number> (1)
487021-52-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3184

$$$$

Untitled Document
  ChemDraw01111817112D
 29 33  0  0  0  0  0  0  0  0999 V2000
   -0.8520    1.4553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4928    2.1980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9564    2.8804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7792    2.8201    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1384    2.0774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6748    1.3950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2839   -0.6523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7476    0.0301    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3884    0.7728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4344    0.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8980    0.1507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5388   -0.5920    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9677    0.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3057   -0.5235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7884    0.1456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7654    1.0289    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5653    1.2311    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9656    0.8267    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5632    1.8287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6425   -2.0859    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7884   -1.2739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0613   -0.8841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4659   -1.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6431   -1.3950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1795   -2.0774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5387   -2.8201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3615   -2.8804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8251   -2.1980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685    0.6700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  1  6  1  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 10 11  2  0      
 11 12  1  0      
  7 12  2  0      
 13 14  1  0      
 14 15  1  0      
 13 15  1  0      
 16 17  2  0      
 16 18  2  0      
 16 19  1  0      
 13 16  1  0      
 11 13  1  0      
 20 21  1  0      
 21 22  2  0      
 22 23  1  0      
 23 24  1  0      
 24 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 20 28  1  0      
 23 28  2  0      
  7 24  1  0      
  1  9  1  0      
  6 29  1  6      
M  END
>  <Catalog Number> (1)
A3210

>  <Item Name> (1)
AZ20

>  <Formula> (1)
C21H24N4O3S

>  <MolWeight> (1)
412.51

>  <CAS Number> (1)
1233339-22-4

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3210

$$$$

Untitled Document
  ChemDraw02192014412D
 25 27  0  0  0  0  0  0  0  0999 V2000
   -0.9418    0.9269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6490    0.1556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1653    0.0235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6869    0.6627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3941    1.4340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4202    1.5661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4581   -0.7478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7562    1.0590    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6241    1.8734    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5705    1.1911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8883    0.2446    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1065    2.5426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5889    3.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7681    3.2950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9273    2.4594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0635   -1.3870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2293   -2.1583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0437   -2.2904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5652   -1.6512    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2725   -0.8799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4904   -2.9840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2881   -2.7734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3343   -1.9497    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2923   -2.7975    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9273   -3.2950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  3  7  1  0      
  1  8  1  0      
  8  9  1  0      
  8 10  2  0      
  8 11  2  0      
  9 12  1  0      
 12 13  1  0      
 12 14  1  0      
 12 15  1  0      
  7 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 20  7  2  0      
 18 21  2  0      
 21 22  1  0      
 22 23  2  0      
 23 19  1  0      
 17 24  1  0      
 22 25  1  0      
V    1 3
V    2 4
V    3 5
V    4 6
V    5 1
V    6 2
V    7 6
V   16 7
V   17 8
V   18 8a
V   19 4
V   20 5
V   21 1
V   22 2
V   23 3
M  END
>  <Catalog Number> (1)
A3340

>  <Item Name> (1)
CZC24832

>  <Formula> (1)
C15H17FN6O2S

>  <MolWeight> (1)
364.4

>  <CAS Number> (1)
1159824-67-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3340

$$$$

Untitled Document
  ChemDraw04081418202D
 16 17  0  0  0  0  0  0  0  0999 V2000
   -0.8963   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8963    1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3252   -0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3252    0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.6028   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9127    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6028    0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1818   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1818    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0877    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8963   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8963    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6108   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6108    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3252   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3252    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 11  1  0      
  2 12  1  0      
  3 13  1  0      
  4 14  1  0      
  5  8  1  0      
 10  5  1  0      
  6 10  1  0      
  6 15  1  0      
  6 16  1  0      
  7  9  1  0      
  7 10  2  0      
  8  9  1  0      
  8 11  2  0      
 12  9  2  0      
 11 13  1  0      
 14 12  1  0      
 13 14  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
M  END
>  <Catalog Number> (1)
A3368

>  <Item Name> (1)
DMAT

>  <Formula> (1)
C9H7Br4N3

>  <MolWeight> (1)
476.79

>  <CAS Number> (1)
749234-11-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3368

$$$$

Untitled Document
  ChemDraw06111414452D
 25 27  0  0  0  0  0  0  0  0999 V2000
    0.4520    0.0401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2310    0.3119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8558   -0.2267    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9474    2.6531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1369    2.4991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8651    1.7201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4037    1.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2142    1.2493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4860    2.0283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1043    1.4009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9759    0.3899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1728    0.5788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2951   -0.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7959   -1.0277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1151   -1.7884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9335   -1.8924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4327   -1.2356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1135   -0.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2527   -2.6531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6011    1.8287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3243    1.4318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0297    1.8596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7529    1.4626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7529    0.6244    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2980   -0.7704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  4  5  1  0      
  5  6  2  0      
  6  7  1  0      
  7  8  2  0      
  8  9  1  0      
  4  9  2  0      
 11 12  2  0      
 10 12  1  0      
  6 10  1  0      
  7 11  1  0      
 13 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 13 18  2  0      
 16 19  1  0      
 11 13  1  0      
 20 21  1  0      
 21 22  1  0      
 22 23  1  0      
 10 20  1  0      
  8 24  1  0      
  1 12  1  0      
  1 25  2  0      
M  END
>  <Catalog Number> (1)
A3420

>  <Item Name> (1)
FMK

>  <Formula> (1)
C18H19FN4O2

>  <MolWeight> (1)
342.37

>  <CAS Number> (1)
821794-92-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3420

$$$$

Untitled Document
  ChemDraw03192010552D
 45 48  0  0  0  0  0  0  0  0999 V2000
    2.4309   -3.3383    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2157   -3.0839    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9614   -2.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1545   -2.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9001   -1.3422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4526   -0.7295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2595   -0.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5138   -1.6864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1982    0.0553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3914    0.2274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7779   -0.3242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0637    0.0888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2358    0.8957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0564    0.9813    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3769    1.4482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2048    2.2550    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8175    2.8075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6454    3.6143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1394    3.8687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7521    3.3162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5800    2.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1617    1.1938    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338    0.3869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1186    0.1326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2907   -0.6743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0755   -0.9287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6882   -0.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5161    0.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7313    0.6850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7307    1.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5151    1.7655    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0005    1.0984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7211   -0.1655    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4701   -3.8687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0005   -2.8295    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2792   -3.4104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2563   -2.5857    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5684   -2.6086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0810   -2.5629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2335   -1.7610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8021   -3.7335    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7885   -2.9086    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9637   -2.9222    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6134   -2.8950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7749   -2.0837    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  7  1  0      
  7  8  1  0      
  3  8  1  0      
  6  9  1  0      
  9 10  1  0      
 10 11  2  0      
 11 12  1  0      
 12 13  2  0      
 13 14  1  0      
 10 14  1  0      
 13 15  1  0      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 20 21  1  0      
 16 21  1  0      
 15 22  2  0      
 22 23  1  0      
 23 24  1  0      
 24 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 29  2  0      
 24 29  1  0      
 29 30  1  0      
 30 31  2  0      
 31 32  1  0      
 28 32  1  0      
 23 33  2  0      
 12 33  1  0      
  2 34  1  0      
  2 35  2  0      
 36 37  2  0      
 37 38  1  0      
 37 39  1  0      
 37 40  2  0      
 41 42  2  0      
 42 43  1  0      
 42 44  1  0      
 42 45  2  0      
M  END
>  <Catalog Number> (1)
A3432

>  <Item Name> (1)
GDC-0941 dimethanesulfonate

>  <Formula> (1)
C25H35N7O9S4

>  <MolWeight> (1)
705.85

>  <CAS Number> (1)
957054-33-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3432

$$$$

Untitled Document
  ChemDraw02202009102D
 38 44  0  0  0  0  0  0  0  0999 V2000
    2.5051   -0.5109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5051   -1.3359    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2196   -1.7484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9340   -1.3359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9340   -0.5109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2196   -0.0984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7906   -1.7484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0761   -1.3359    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7906   -2.5734    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0761   -0.5109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4311    0.0034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732   -0.1801    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7311   -0.9234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732   -1.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4311   -1.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5561   -0.9234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9686   -1.6379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5561   -2.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7311   -2.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7697   -0.1266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    0.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9686   -3.0669    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4841    0.2859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6977    1.0828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5215    1.1260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8172    0.3558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1760   -0.1634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1760   -0.9884    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9340    1.8405    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2852    1.7973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4602    1.7973    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2052    2.5819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8727    3.0669    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5401    2.5819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9081    1.1842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1012    1.3557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1538    2.1404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3982    2.7535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  2  7  1  0      
  7  8  1  0      
  7  9  2  0      
  8 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15  8  1  0      
 13 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 14  2  0      
 16 20  1  0      
 12 21  1  0      
 21 20  2  0      
 18 22  1  0      
 20 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 23  1  0      
 27 28  2  0      
 25 29  2  0      
 24 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 33  2  0      
 33 34  1  0      
 34 30  2  0      
 31 35  1  0      
 35 36  2  0      
 36 37  1  0      
 37 38  2  0      
 38 32  1  0      
M  END
>  <Catalog Number> (1)
A3570

>  <Item Name> (1)
LY2090314

>  <Formula> (1)
C28H25FN6O3

>  <MolWeight> (1)
512.53

>  <CAS Number> (1)
603288-22-8

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3570

$$$$

Untitled Document
  ChemDraw11221617012D
 22 23  0  0  0  0  0  0  0  0999 V2000
   -0.2586    1.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1885    0.3669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0125    0.4074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3894    1.1412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2135    1.1817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5904    1.9155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.6089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3194    2.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9424    1.8346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5203    3.3428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4144    1.9560    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1885   -0.3669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2586   -1.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0125   -0.4074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3894   -1.1412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2135   -1.1817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5904   -1.9155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.6089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3194   -2.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9424   -1.8346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5203   -3.3428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4144   -1.9560    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  6  7  2  0      
  7  8  1  0      
  8  9  2  0      
  4  9  1  0      
  7 10  1  0      
  6 11  1  0      
  2 12  1  0      
 12 13  1  0      
 12 14  1  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 15 20  1  0      
 18 21  1  0      
 17 22  1  0      
M  END
>  <Catalog Number> (1)
A3664

>  <Item Name> (1)
Nordihydroguaiaretic acid

>  <Formula> (1)
C18H22O4

>  <MolWeight> (1)
302.36

>  <CAS Number> (1)
500-38-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3664

$$$$

Untitled Document
  ChemDraw03192014012D
 30 32  0  0  0  0  0  0  0  0999 V2000
   -1.7862   -1.0312    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    1.4438    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    3.0938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151   -1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151   -1.8562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -1.8562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -1.8563    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -3.0938    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -1.4438    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151   -2.2687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3150    1.1138    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  1  0      
  7 12  1  0      
  6 13  2  0      
  2 13  1  0      
  1 14  1  0      
 14 15  1  0      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18  1  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  2  0      
 22  4  1  0      
 21 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 22  1  0      
 20 27  1  0      
 20 28  1  0      
 24 29  1  0      
M  END
>  <Catalog Number> (1)
A3674

>  <Item Name> (1)
NVP-BKM120 Hydrochloride

>  <Formula> (1)
C18H22ClF3N6O2

>  <MolWeight> (1)
446.85

>  <CAS Number> (1)
1312445-63-8

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3674

$$$$

Untitled Document
  ChemDraw03192014352D
 27 30  0  0  0  0  0  0  0  0999 V2000
    2.9532    0.2101    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8093   -0.3957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2674   -1.0178    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5423   -0.8595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101   -0.0791    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2681    0.5429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5359    1.3233    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0060    1.9453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2618    2.7257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0715    2.8839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6134    2.2619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3456    1.4815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5415    0.3846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0842   -1.4815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2009    0.8804    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8762    0.4065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6342   -0.3822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6819    0.5841    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2455   -0.0271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9909   -0.8185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1853   -0.9961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8164   -2.2619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3583   -2.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1680   -2.7257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4358   -1.9453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8939   -1.3233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2455   -1.7870    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  1  0      
  7 12  1  0      
  6 13  1  0      
  2 13  2  0      
  4 14  1  0      
 13 15  1  0      
 15 16  1  0      
 16 17  2  0      
 17  2  1  0      
 16 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  2  0      
 21 17  1  0      
 14 22  2  0      
 22 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 14  1  0      
 25 27  1  0      
M  END
>  <Catalog Number> (1)
A3724

>  <Item Name> (1)
PI-103 Hydrochloride

>  <Formula> (1)
C19H17ClN4O3

>  <MolWeight> (1)
384.82

>  <CAS Number> (1)
371935-79-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3724

$$$$

Untitled Document
  ChemDraw04081422102D
 13 14  0  0  0  0  0  0  0  0999 V2000
   -0.2775   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775    1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.7065   -0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.7065    0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.2216   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2216    0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4369   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4369    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9920   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9920    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 10  1  0      
  2 11  1  0      
  3 12  1  0      
  4 13  1  0      
  5  7  1  0      
  5  8  2  0      
  7  6  1  0      
  6  9  2  0      
  9  8  1  0      
 10  8  1  0      
  9 11  1  0      
 12 10  2  0      
 11 13  2  0      
 13 12  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
M  END
>  <Catalog Number> (1)
A3861

>  <Item Name> (1)
TBB

>  <Formula> (1)
C6HBr4N3

>  <MolWeight> (1)
434.71

>  <CAS Number> (1)
17374-26-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3861

$$$$

Untitled Document
  ChemDraw09261418152D
 22 24  0  0  0  0  0  0  0  0999 V2000
    0.3363   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3782   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3782   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3363   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0507   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0507   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1628   -0.9826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6478   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1628   -2.3174    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4178   -0.1979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8657    0.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1207    1.1998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9276    1.3713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4797    0.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2247   -0.0264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826    2.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3363   -0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0507    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0507    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7652    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4797    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7652    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  2  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9  3  1  0      
  7 10  1  0      
 10 11  2  0      
 11 12  1  0      
 12 13  2  0      
 13 14  1  0      
 14 15  2  0      
 15 10  1  0      
 13 16  1  0      
  1 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 20 21  1  0      
 20 22  2  0      
M  END
>  <Catalog Number> (1)
A3894

>  <Item Name> (1)
TTP 22

>  <Formula> (1)
C16H14N2O2S2

>  <MolWeight> (1)
330.42

>  <CAS Number> (1)
329907-28-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3894

$$$$

Untitled Document
  ChemDraw03202009492D
 27 27  0  0  0  0  0  0  0  0999 V2000
   -2.8579    1.2214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.3964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.0161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.3964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.2214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.6339    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.6339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.2214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.4589    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.3964    0.0000 V   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.0161    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.8089    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.4286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.8411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.4286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.3964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.8411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.4286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.3964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.8089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.6661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.6661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6693    1.5384    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.0161    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9423   -2.4589    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8964   -0.6851    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8987   -1.6293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  5  7  1  0      
  7  8  1  0      
  7  9  2  0      
  8 10  1  0      
  4 11  1  0      
 11 10  1  0      
 10 12  2  0      
 10 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15 16  2  0      
 10 16  1  0      
 15 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 20 16  1  0      
 14 21  2  0      
 17 22  1  0      
 10 23  1  0      
 10 24  1  0      
M  END
>  <Catalog Number> (1)
A3923

>  <Item Name> (1)
VO-Ohpic trihydrate

>  <Formula> (1)
C12H16N2O11V

>  <MolWeight> (1)
415.2

>  <CAS Number> (1)
476310-60-8

>  <Target> (1)
Cell Cycle/Checkpoint

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3923

$$$$

Untitled Document
  ChemDraw02281417002D
 26 29  0  0  0  0  0  0  0  0999 V2000
    2.1336   -3.2151    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1484   -0.1857    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086   -1.7862    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0711   -1.0717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4809    0.9703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086   -0.3572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086    2.5006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5461    1.7862    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5461    3.2151    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7615   -0.7377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3414   -0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1336   -1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8961   -2.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0711    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8961   -1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2346    0.6348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5461   -2.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086   -3.2151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8961    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5899   -1.5447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5461   -0.4828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9491    1.0473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8961    1.7862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1336    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1336    2.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 17  1  0      
 18  1  1  0      
  2 10  1  0      
  2 11  1  0      
 16  2  1  0      
  3 12  1  0      
  3 13  1  0      
  3 15  1  0      
 11  4  2  0      
 15  4  1  0      
 14  5  1  0      
  5 16  2  0      
 15  6  2  0      
  6 19  1  0      
 24  7  2  0      
 26  7  1  0      
 25  8  1  0      
  8 26  2  0      
  9 26  1  0      
 10 20  1  0      
 10 21  1  0      
 14 11  1  0      
 17 12  1  0      
 13 18  1  0      
 19 14  2  0      
 16 22  1  0      
 19 23  1  0      
 24 23  1  0      
 23 25  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
M  END
>  <Catalog Number> (1)
A3927

>  <Item Name> (1)
VS-5584 (SB2343)

>  <Formula> (1)
C17H22N8O

>  <MolWeight> (1)
354.41

>  <CAS Number> (1)
1246560-33-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3927

$$$$

Untitled Document
  ChemDraw02202016012D
 32 35  0  0  0  0  0  0  0  0999 V2000
    2.9619   -3.2936    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7589    1.4887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1458   -1.1406    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3724   -3.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5390   -3.8831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8753   -0.1410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1298    3.8831    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5514    3.7383    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2558    0.4038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6875    0.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2953    1.2279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0808    0.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9643    1.7107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6533   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2305   -1.5250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4573    1.5659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5409    2.3865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084   -2.3197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8806    2.5315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3847   -2.7041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1280    2.8694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0296   -1.3200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5856   -2.9092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6067   -1.9095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2936    2.7245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5514   -2.7165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9625    2.2417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3772    3.5453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7152    2.5796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7988    3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2431   -0.5231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4036   -1.6960    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  1  0      
  1  5  2  0      
  1 20  1  0      
  1 26  2  0      
 12  2  1  0      
  2 13  1  0      
  3 14  2  0      
  9  6  1  0      
  6 10  1  0      
  6 14  1  0      
 28  7  2  0      
  7 30  1  0      
  8 30  1  0      
 11  9  1  0      
 10 12  1  0      
 11 13  1  0      
 16 11  2  0      
 13 19  2  0      
 14 15  1  0      
 15 18  2  0      
 15 22  1  0      
 17 16  1  0      
 21 17  2  0      
 17 25  1  0      
 18 23  1  0      
 21 19  1  0      
 23 20  2  0      
 20 24  1  0      
 24 22  2  0      
 27 25  2  0      
 25 28  1  0      
 29 27  1  0      
 29 30  2  0      
 22 31  1  0      
 24 32  1  0      
V    1 0
V    2 2
V    3 3
V    4 4
V    5 5
V    6 6
V    7 7
V    8 8
V    9 9
V   10 10
V   11 11
V   12 12
V   13 13
V   14 14
V   15 15
V   16 16
V   17 17
V   18 18
V   19 19
V   20 20
V   21 21
V   22 22
V   23 23
V   24 24
V   25 25
V   26 27
V   27 28
V   28 29
V   29 30
V   30 31
M  END
>  <Catalog Number> (1)
A3940

>  <Item Name> (1)
XL388

>  <Formula> (1)
C23H22FN3O4S

>  <MolWeight> (1)
455.5

>  <CAS Number> (1)
1251156-08-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3940

$$$$

Untitled Document
  ChemDraw07041410462D
 26 29  0  0  0  0  0  0  0  0999 V2000
    0.5987   -2.2573    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5513   -0.4795    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6475   -2.3781    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3384    1.5131    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5513   -2.3781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1956   -0.7960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5987   -1.2333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0032   -1.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7942   -0.6314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0032   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5513   -1.1124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9707   -1.7453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1854    0.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4133   -0.4998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3708   -0.1610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6089    0.1021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5663    0.4409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3810    1.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0994   -1.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0994   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9575    1.6447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0000    1.3059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1530    2.2466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1956    1.9078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7721    2.3781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6475   -1.1124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 10  1  1  0      
  1 12  1  0      
  2 11  1  0      
  3 20  2  0      
  4 21  1  0      
  5 10  1  0      
 20  5  1  0      
  6 26  3  0      
  7  8  1  0      
  7  9  1  0      
 12  7  2  0      
 10  8  2  0      
 11  8  1  0      
  9 14  1  0      
  9 15  2  0      
 11 19  2  0      
 16 13  1  0      
 13 17  2  0      
 13 18  1  0      
 14 16  2  0      
 17 15  1  0      
 18 21  1  0      
 18 22  2  0      
 19 20  1  0      
 19 26  1  0      
 21 23  2  0      
 24 22  1  0      
 23 25  1  0      
 25 24  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
M  END
>  <Catalog Number> (1)
A3963

>  <Item Name> (1)
A-769662

>  <Formula> (1)
C20H12N2O3S

>  <MolWeight> (1)
360.39

>  <CAS Number> (1)
844499-71-4

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3963

$$$$

Untitled Document
  ChemDraw02251418422D
 40 44  0  0  0  0  0  0  0  0999 V2000
    1.7763   -1.6562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4889   -2.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2052   -1.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2088   -0.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4961   -0.4218    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7799   -0.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4853   -2.8968    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9179   -2.0781    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9251   -0.4281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0672   -0.4156    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0708    0.4094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7871    0.8188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7907    1.6438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0780    2.0594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3617    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3581    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3509    2.0656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0672    1.6562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0708    0.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3581    0.4156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7799    2.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4961    1.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4997    0.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7871    0.4218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2088    2.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9251    1.6687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9287    0.8437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2160    0.4281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2196   -0.3969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9359   -0.8063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7907   -0.4031    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7763    2.8968    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3617   -0.4094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3473    2.8906    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5069    2.0531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2196    1.6375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9359    2.0469    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5105    2.8781    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5033    1.2281    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7831   -0.0060    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  2  7  1  1      
  3  8  1  1      
  4  9  1  1      
  6 10  1  6      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15 16  2  0      
 16 11  1  0      
 15 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 20 16  1  0      
 18 21  1  0      
 21 22  1  0      
 22 23  2  0      
 23 24  1  0      
 24 19  1  0      
 22 25  1  0      
 25 26  2  0      
 26 27  1  0      
 27 28  2  0      
 28 23  1  0      
 28 29  1  0      
 29 30  1  0      
 24 31  2  0      
 21 32  2  0      
 20 33  1  0      
 17 34  1  0      
 13 35  1  0      
 35 36  1  0      
 36 37  1  0      
 35 38  2  0      
 13 39  1  6      
 11 40  1  1      
M  END
>  <Catalog Number> (1)
A3966

>  <Item Name> (1)
Doxorubicin

>  <Formula> (1)
C27H29NO11

>  <MolWeight> (1)
543.52

>  <CAS Number> (1)
23214-92-8

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A3966

$$$$

Untitled Document
  ChemDraw07041411232D
 36 40  0  0  0  0  0  0  0  0999 V2000
   -0.7102   -0.7835    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9012   -2.8184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1034   -3.1394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3753    3.1394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6594    3.1394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7891   -2.1763    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3231   -2.1763    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8791   -1.2132    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4121    0.3591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3753    0.9152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4121    1.4712    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9913   -3.1394    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3384    2.5834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3451   -1.8553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7891   -2.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2330   -1.8553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9012   -2.1763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3451   -3.1394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2330   -1.2132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3231   -0.8921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4490   -0.1970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1896   -0.2641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7701    0.3591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8791   -1.8553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4352   -2.1763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7332   -0.1970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7332    0.9152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9913   -1.8553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4352   -2.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5473   -2.1763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5473   -2.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6963    1.4712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7332    2.0273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3753    2.0273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6963    2.5834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6594   -2.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 19  1  1  0      
  1 21  1  0      
  2 17  1  0      
 18  2  1  0      
  3 31  1  0      
  3 36  1  0      
  4 35  2  0      
  5 13  1  0      
  6 14  1  0      
  6 15  1  0      
  6 16  1  0      
  7 16  2  0      
 24  7  1  0      
 20  8  1  0      
 24  8  2  0      
  9 23  1  0      
  9 26  1  0      
  9 27  1  0      
 27 10  1  0      
 32 10  2  0      
 11 27  2  0      
 33 11  1  0      
 29 12  2  0      
 12 31  1  0      
 13 35  1  0      
 17 14  1  0      
 15 18  1  0      
 16 19  1  0      
 19 20  2  0      
 22 20  1  0      
 21 22  2  0      
 21 23  1  0      
 24 25  1  0      
 28 25  2  0      
 25 29  1  0      
 30 28  1  0      
 30 31  2  0      
 32 34  1  0      
 34 33  2  0      
 34 35  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
V   36 35
M  END
>  <Catalog Number> (1)
A4097

>  <Item Name> (1)
CUDC-907

>  <Formula> (1)
C23H24N8O4S

>  <MolWeight> (1)
508.55

>  <CAS Number> (1)
1339928-25-4

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A4097

$$$$

Untitled Document
  ChemDraw06111413572D
 23 24  0  0  0  0  0  0  0  0999 V2000
   -2.0876    2.1130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9125    2.0982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3121    1.3764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8868    0.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0619    0.6843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6623    1.4061    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6880    2.8348    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8375    1.4209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4122    0.7139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4379    2.1427    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4127    0.7288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8379    0.0218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4383   -0.6999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8636   -1.4069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6885   -1.3921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0881   -0.6703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6628    0.0367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9129   -0.6555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3121    0.0655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1138   -2.0990    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9377   -2.0842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4640   -2.1287    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8888   -2.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  1  7  2  0      
  6  8  1  0      
  8  9  1  0      
  8 10  2  0      
  9 11  2  0      
 11 12  1  0      
 12 13  2  0      
 13 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 12  1  0      
 16 18  1  0      
 18 19  1  0      
 15 20  1  0      
 20 21  1  0      
 14 22  1  0      
 22 23  1  0      
M  STY  1   1 SUP
M  SLB  1   1   1
M  SAL   1  2  18  19
M  SBL   1  1  19
M  SMT   1 OMe
M  SBV   1  19   -0.8249   -0.0148
M  STY  1   2 SUP
M  SLB  1   2   2
M  SAL   2  2  20  21
M  SBL   2  1  21
M  SMT   2 OMe
M  SBV   2  21   -0.4253    0.7069
M  STY  1   3 SUP
M  SLB  1   3   3
M  SAL   3  2  22  23
M  SBL   3  1  23
M  SMT   3 ^OMe
M  SBV   3  23    0.3996    0.7218
M  END
>  <Catalog Number> (1)
A4455

>  <Item Name> (1)
Piperlongumine

>  <Formula> (1)
C17H19NO5

>  <MolWeight> (1)
317.34

>  <CAS Number> (1)
20069-09-4

>  <Target> (1)
Apoptosis

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A4455

$$$$

Untitled Document
  ChemDraw02251414122D
 27 31  0  0  0  0  0  0  0  0999 V2000
    0.2006   -0.6949    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0030   -2.0847    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6079    1.3898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2006    0.6949    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4042    2.7797    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0030    1.3898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    2.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2066    0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2066    2.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2006    1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0030    0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4042   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2006    2.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0030   -0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4042    1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4042   -1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0030    2.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2066   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2006   -1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2006   -2.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2066   -1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6079   -0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0030   -1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2006   -2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -2.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0030   -2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 15  1  1  0      
  1 20  1  0      
  2 17  1  0      
  2 21  1  0      
  3  9  1  0      
 10  3  1  0      
 11  4  1  0      
 12  4  1  0      
  5 18  2  0      
  6  7  1  0      
  6  8  1  0      
  6 11  1  0      
  7 10  1  0      
  9  8  1  0      
 11 14  2  0      
 12 13  1  0      
 16 12  2  0      
 13 15  1  0      
 19 13  2  0      
 14 18  1  0      
 17 15  2  0      
 18 16  1  0      
 17 22  1  0      
 23 19  1  0      
 20 21  1  0      
 20 24  2  0      
 25 21  2  0      
 22 23  2  0      
 24 26  1  0      
 27 25  1  0      
 26 27  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
M  END
>  <Catalog Number> (1)
A4605

>  <Item Name> (1)
KU 55933

>  <Formula> (1)
C21H17NO3S2

>  <MolWeight> (1)
395.49

>  <CAS Number> (1)
587871-26-9

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A4605

$$$$

Untitled Document
  ChemDraw02251418482D
 31 34  0  0  0  0  0  0  0  0999 V2000
    0.0000    1.0442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.6317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.1933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.1933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1715   -1.4128    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9920   -1.4990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3276   -0.7453    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.0442    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1345   -0.5738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7179   -1.1572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4045   -2.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.0183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.8692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.2817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.8692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.2817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.1067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.5192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.1067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.4308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.0183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.2558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4412   -2.0142    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0690   -2.9672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -3.5192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3965   -3.1067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2250   -2.2997    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2620   -3.1387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  6  1  2  0      
  4  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9  5  1  0      
  6 10  1  0      
  3 11  1  0      
  9 12  1  0      
 12 13  1  0      
  8 14  1  0      
 11 15  3  0      
 10 16  1  0      
 17 16  1  6      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 17  1  0      
 15 23  1  0      
 23 24  1  0      
 23 25  1  0      
 23 26  1  0      
 14 27  1  0      
 27 28  2  0      
 28 29  1  0      
 29 30  1  0      
 30 14  2  0      
 27 31  1  0      
M  END
>  <Catalog Number> (1)
A5072

>  <Item Name> (1)
GSK690693

>  <Formula> (1)
C21H27N7O3

>  <MolWeight> (1)
425.48

>  <CAS Number> (1)
937174-76-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5072

$$$$

Untitled Document
  ChemDraw06111414162D
 34 38  0  0  0  0  0  0  0  0999 V2000
    0.0000    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.2687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.9188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.9188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.9188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.6812    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.9188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  1  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
 10  2  1  0      
  8 11  1  0      
  5 12  1  0      
 10 13  1  0      
 11 14  1  0      
 14 15  1  0      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18 11  1  0      
 13 19  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 23  1  0      
 23 13  1  0      
 12 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 27  1  0      
 27 28  2  0      
 28 12  1  0      
 15 29  1  1      
 17 30  1  1      
 26 31  1  0      
 31 32  1  0      
 25 33  1  0      
 33 34  1  0      
M  END
>  <Catalog Number> (1)
A5078

>  <Item Name> (1)
KU-0063794

>  <Formula> (1)
C25H31N5O4

>  <MolWeight> (1)
465.54

>  <CAS Number> (1)
938440-64-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5078

$$$$

Untitled Document
  ChemDraw06111414172D
 31 35  0  0  0  0  0  0  0  0999 V2000
    2.1485   -1.3071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5652   -1.8905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7787   -2.6874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5756   -2.9009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1589   -2.3175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9454   -1.5206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9350   -0.5102    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1381   -0.2967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5548   -0.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7683   -1.6769    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9246    0.5002    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2421   -0.6665    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8255   -1.2499    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4089   -1.8333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2421   -1.8333    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4089   -0.6665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5080    1.0836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3048    0.8700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8882    1.4534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6747    2.2503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8778    2.4638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2944    1.8805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2057   -1.6197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7891   -2.2031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5756   -3.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7787   -3.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1953   -2.6301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1240    2.9422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048    3.5833    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8346    3.2877    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1589   -3.5833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  1  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
 10  2  1  0      
  8 11  1  0      
  9 12  1  0      
 12 13  1  0      
 13 14  1  0      
 13 15  2  0      
 13 16  2  0      
 11 17  1  0      
 17 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 17  2  0      
 14 23  2  0      
 23 24  1  0      
 24 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 14  1  0      
 20 28  2  0      
 28 29  1  0      
 29 30  1  0      
 30 21  2  0      
 25 31  1  0      
M  END
>  <Catalog Number> (1)
A5112

>  <Item Name> (1)
XL147

>  <Formula> (1)
C21H16N6O2S2

>  <MolWeight> (1)
448.52

>  <CAS Number> (1)
956958-53-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5112

$$$$

Untitled Document
  ChemDraw02242009042D
 18 20  0  0  0  0  0  0  0  0999 V2000
    0.4735   -0.1238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7429    0.6559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5321    0.8963    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5474    1.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7676    1.9906    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2237    2.1936    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2704    1.3322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5544    1.3475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8115    0.6643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2237   -0.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8109   -0.7647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2230   -1.4793    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8102   -2.1936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9852   -2.1932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5730   -1.4786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9859   -0.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5737   -0.0496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9865    0.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  4  6  2  0      
  2  7  1  0      
  5  7  1  0      
  7  8  2  0      
  9 10  2  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 11 16  1  0      
 16 17  1  0      
 17 18  2  0      
  9 18  1  0      
 18  8  1  0      
M  END
>  <Catalog Number> (1)
A5176

>  <Item Name> (1)
AS-605240

>  <Formula> (1)
C12H7N3O2S

>  <MolWeight> (1)
257.27

>  <CAS Number> (1)
648450-29-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5176

$$$$

Untitled Document
  ChemDraw07021414072D
 24 25  0  0  0  0  0  0  0  0999 V2000
   -0.4658   -2.9052    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.2280   -1.5851    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7485    0.4313    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9901   -1.5851    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2280   -2.3473    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5481    0.7014    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5481    1.8372    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2280   -0.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749    0.5602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    1.6992    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4658   -1.5851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6774   -0.9251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0847   -0.9251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0585   -0.2650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0847   -2.2452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0585   -1.5851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8880   -0.4419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8165   -0.1853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6774   -2.2452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8880    0.3203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3149    0.9412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3265   -0.7517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8518    2.1472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7722    2.9052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 15  1  0      
  2  4  2  0      
  2  5  2  0      
  2  8  1  0      
  2 11  1  0      
 14  3  1  0      
  3 21  1  0      
  6 20  1  0      
  7 23  2  0      
  8 17  1  0      
 18  9  1  0      
 21  9  2  0      
 10 21  1  0      
 10 23  1  0      
 11 13  1  0      
 11 15  2  0      
 13 12  2  0      
 12 14  1  0      
 12 16  1  0      
 18 14  2  0      
 19 15  1  0      
 16 19  2  0      
 17 20  1  0      
 18 22  1  0      
 23 24  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
M  END
>  <Catalog Number> (1)
A5449

>  <Item Name> (1)
PIK-93

>  <Formula> (1)
C14H16ClN3O4S2

>  <MolWeight> (1)
389.88

>  <CAS Number> (1)
593960-11-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5449

$$$$

Untitled Document
  ChemDraw02222015562D
 30 33  0  0  0  0  0  0  0  0999 V2000
    0.2063    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6188    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4438    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8563    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4438    2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6188    2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2063    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4438    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8562    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6812    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6187    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0312    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8562    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2687   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8562   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0312   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6188   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6188   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2062   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6187   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2062   -0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0312    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0313   -2.8579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0937   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4437   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8562   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6812   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0937   -1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6812   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8562   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  2  7  1  0      
  8  9  1  0      
  9  3  1  0      
  9 10  2  0      
  7 11  1  0      
 11 12  1  0      
 12 13  2  0      
 13 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  1  0      
 17 12  1  0      
 16 18  1  0      
 18 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 17  2  0      
 11 22  1  1      
 18 23  2  0      
 14 24  1  0      
 20 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 28  1  0      
 28 29  1  0      
 29 30  1  0      
 30 25  1  0      
M  END
>  <Catalog Number> (1)
A5478

>  <Item Name> (1)
AZD6482

>  <Formula> (1)
C22H24N4O4

>  <MolWeight> (1)
408.45

>  <CAS Number> (1)
1173900-33-8

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5478

$$$$

Untitled Document
  ChemDraw02222016072D
 43 47  0  0  0  0  0  0  0  0999 V2000
   -0.3276    2.8727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7401    2.1582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3276    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4974    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9099    2.1582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4974    2.8727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7401    3.5872    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7349    2.1582    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1474    2.8727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3276    4.3016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7401    0.7293    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5651    0.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9776    1.4438    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8026    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151    0.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8026    0.0148    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9776    0.0148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151    2.1582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0401    2.1582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4526    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0401    0.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5651   -0.6997    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9776   -1.4141    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3901   -2.1286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6921   -1.0016    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2631   -1.8266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2631   -2.6516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5487   -3.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1658   -2.6516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1658   -1.8266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5487   -1.4141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8803   -3.0641    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5947   -2.6516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3092   -3.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5947   -1.8266    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3092   -3.8891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0237   -4.3016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7381   -3.8891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7381   -3.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0237   -2.6516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4526   -2.6516    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4526   -4.3016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4526   -1.8266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  1  7  1  0      
  5  8  1  0      
  8  9  1  0      
  7 10  1  0      
  3 11  1  0      
 11 12  1  0      
 12 13  2  0      
 13 14  1  0      
 14 15  1  0      
 15 16  1  0      
 16 17  2  0      
 17 12  1  0      
 14 18  2  0      
 18 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 15  2  0      
 17 22  1  0      
 22 23  1  0      
 23 24  2  0      
 23 25  2  0      
 23 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 29  2  0      
 29 30  1  0      
 30 31  2  0      
 31 26  1  0      
 29 32  1  0      
 32 33  1  0      
 33 34  1  0      
 33 35  2  0      
 34 36  2  0      
 36 37  1  0      
 37 38  2  0      
 38 39  1  0      
 39 40  2  0      
 40 34  1  0      
 39 41  1  0      
 38 42  1  0      
 41 43  1  0      
M  END
>  <Catalog Number> (1)
A5634

>  <Item Name> (1)
SAR245409 (XL765)

>  <Formula> (1)
C31H29N5O6S

>  <MolWeight> (1)
599.66

>  <CAS Number> (1)
1349796-36-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5634

$$$$

Untitled Document
  ChemDraw02222016082D
 24 27  0  0  0  0  0  0  0  0999 V2000
    1.4702   -2.6872    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.7078   -0.5661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1776    2.6872    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7078    2.0553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0578   -0.5661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4704   -1.2805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4704    0.1484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2954   -1.2805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2954    0.1484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4258   -0.0357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4258   -1.0963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5691    0.7767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3494   -0.3179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3494   -0.8142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5691   -1.9089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0629    1.3071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9814    0.2124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8381    1.0249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9814   -1.3444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0629   -2.4391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8381   -2.1570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4702    1.5552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4127    2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2706    1.3556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 21  1  0      
  2  8  1  0      
  2  9  1  0      
  4  3  1  0      
 23  3  2  0      
 24  4  1  0      
  6  5  1  0      
  5  7  1  0      
  5 10  1  0      
  5 11  1  0      
  8  6  1  0      
  7  9  1  0      
 10 12  2  0      
 10 13  1  0      
 11 14  2  0      
 11 15  1  0      
 12 16  1  0      
 17 13  2  0      
 14 19  1  0      
 20 15  2  0      
 16 18  2  0      
 18 17  1  0      
 18 22  1  0      
 19 21  2  0      
 21 20  1  0      
 23 22  1  0      
 22 24  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
M  END
>  <Catalog Number> (1)
A5653

>  <Item Name> (1)
AT7867

>  <Formula> (1)
C20H20ClN3

>  <MolWeight> (1)
337.85

>  <CAS Number> (1)
857531-00-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5653

$$$$

Untitled Document
  ChemDraw02222016422D
 27 28  0  0  0  0  0  0  0  0999 V2000
   -3.9691    0.9765    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9904    1.8012    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7939    0.9553    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9479    0.1519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2714   -1.0068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8407   -0.3032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0961   -0.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0160   -0.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5269   -1.6891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5853    0.3792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3516   -1.6679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2395    0.3579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7824   -2.3715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6702    1.0615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6071   -2.3502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4949    1.0403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0379   -3.0538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9257    1.7440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8889    0.3154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1444    0.9978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7504    1.7227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7136    0.2942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7048    2.2137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9184    3.0106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7422    3.0538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0379    2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3967    1.7644    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  1  3  2  0      
  1  4  2  0      
  1 20  1  0      
  5  6  1  0      
  5  7  1  0      
  6  8  1  0      
  7  9  1  0      
  8 10  1  0      
  9 11  1  0      
 10 12  1  0      
 11 13  1  0      
 12 14  1  0      
 13 15  1  0      
 14 16  1  0      
 15 17  1  0      
 16 18  2  0      
 16 19  1  0      
 18 21  1  0      
 22 19  2  0      
 21 20  2  0      
 20 22  1  0      
  2 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 27  1  0      
 27 23  1  0      
V    1 0
V    2 2
V    3 3
V    4 4
V    5 7
V    6 8
V    7 9
V    8 10
V    9 11
V   10 12
V   11 13
V   12 14
V   13 15
V   14 16
V   15 17
V   16 18
V   17 19
V   18 20
V   19 21
V   20 22
V   21 23
V   22 24
M  END
>  <Catalog Number> (1)
A5884

>  <Item Name> (1)
PHT-427

>  <Formula> (1)
C20H31N3O2S2

>  <MolWeight> (1)
409.61

>  <CAS Number> (1)
1191951-57-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A5884

$$$$

Untitled Document
  ChemDraw02281419032D
 65 68  0  0  0  0  0  0  0  0999 V2000
   -1.7248    3.5527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607    2.9046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5173    2.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8381    2.4960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6022    3.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0455    3.6724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1681    4.0810    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6399    2.7848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0832    3.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3948    1.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6307    1.3196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1873    0.7912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2324    0.1030    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4312    1.0963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099    1.1998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0047    0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6233    1.0181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0047    0.0234    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1967    0.6350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1516   -0.0533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7251   -0.4364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5543   -0.3981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224   -0.0916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6800   -1.1247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2535   -1.5078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0827   -1.4695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4854   -1.1247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8972   -1.2602    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0845   -2.1765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4209   -2.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5785   -2.6570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1575   -3.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2846   -3.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5344   -2.8069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9668   -3.1988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3437   -2.9032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7761   -3.2950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1530   -2.9995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4146   -3.3913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0378   -3.0957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4146   -4.0810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5080   -3.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0378   -2.4060    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4405   -2.0612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1053   -2.9763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7026   -3.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1053   -2.2866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7026   -1.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2999   -2.2866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2999   -2.9763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8972   -1.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7026   -1.2521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2999   -1.5969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1053   -0.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2999   -0.9072    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5080   -1.2521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1053   -0.2175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5080    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5080    0.8170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1053    1.1619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7026    0.8170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7026    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9107   -0.2175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9107   -0.9072    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6233    1.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  1  7  1  6      
  2  8  1  1      
  8  9  1  0      
  4 10  1  1      
 10 11  1  0      
 11 12  1  0      
 12 13  1  6      
 12 14  1  0      
 11 15  1  6      
 14 16  1  0      
 16 17  1  0      
 16 18  2  0      
 17 19  1  0      
 19 20  2  0      
 20 21  1  0      
 20 22  1  0      
 21 23  1  1      
 21 24  1  0      
 24 25  1  0      
 24 26  1  6      
 26 27  1  0      
 25 28  2  0      
 25 29  1  0      
 29 30  1  1      
 29 31  1  0      
 31 32  1  0      
 32 33  1  6      
 32 34  1  0      
 34 35  2  0      
 35 36  1  0      
 36 37  2  0      
 37 38  1  0      
 38 39  2  0      
 39 40  1  0      
 39 41  1  0      
 40 42  1  0      
 40 43  1  6      
 43 44  1  0      
 42 45  1  0      
 45 46  1  0      
 45 47  1  6      
 47 48  1  0      
 48 49  1  0      
 49 50  1  0      
 50 46  1  0      
 49 51  1  1      
 48 52  1  0      
 48 53  1  1      
 52 54  1  0      
 52 55  2  0      
 54 56  2  0      
 54 57  1  0      
 57 58  1  0      
 58 59  1  0      
 59 60  1  0      
 60 61  1  0      
 61 62  1  0      
 62 57  1  0      
 58 63  1  1      
 63 64  2  0      
 63 13  1  0      
 17 65  1  6      
M  END
>  <Catalog Number> (1)
A8167

>  <Item Name> (1)
Rapamycin (Sirolimus)

>  <Formula> (1)
C51H79NO13

>  <MolWeight> (1)
914.18

>  <CAS Number> (1)
53123-88-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8167

$$$$

Untitled Document
csChFnd80/01281314062D
 68 71  0  0  0  0  0  0  0  0999 V2000
    2.9726   19.2313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7816   20.3739    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5575   17.9594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7485   16.8168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3334   15.5449    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5243   14.4023    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.1093   13.1304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5033   13.0010    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.3124   14.1436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7274   15.4155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1303   14.5317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5454   15.8037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0883   11.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4823   11.5997    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.0672   10.3277    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.2913   12.7422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7882    8.9508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6172    8.1746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8854    6.8005    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3258    8.7150    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.1474   10.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8514   10.6508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7338    9.7996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9121    8.4061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2081    7.8638    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3858    6.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6924    5.9721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2844    5.6109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4821    4.2249    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.9974    6.1230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3769    3.3577    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5753    1.9669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8790    1.4433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9842    2.3105    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7858    3.7013    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2244    4.8508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.6367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2420    1.6846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6896    2.1870    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.8492    1.3973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5086    3.9292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8359    4.3744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0161    2.1709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9357    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2271   10.3915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2228    9.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2513   10.7360    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    9.3003    8.3978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2694    1.5472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4363    2.3208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6897    1.6971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8565    2.4707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1099    1.8469    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   16.5010    3.0137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1964    0.4496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4828    4.1196    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   15.1428    6.0711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1554    3.6744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5626    6.7819    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   16.4701    6.5163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8975   10.1074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1648   12.1333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0012    8.4335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3472    7.9324    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.7546    5.7040    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3573    5.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5596    8.6324    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0240    7.4378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10  5  1  0  0  0  0
  5  4  1  6  0  0  0
  6 11  1  1  0  0  0
 11 12  1  0  0  0  0
  8 13  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  6  0  0  0
 15 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 20  1  0  0  0  0
 20 18  1  1  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 29  1  0  0  0  0
 29 36  1  1  0  0  0
 31 37  1  1  0  0  0
 34 38  1  6  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 39 41  1  6  0  0  0
 41 42  1  0  0  0  0
 40 43  2  0  0  0  0
 40 44  1  0  0  0  0
 15 45  1  0  0  0  0
 45 46  1  0  0  0  0
 46 47  1  0  0  0  0
 46 48  2  0  0  0  0
 43 49  1  0  0  0  0
 49 50  2  0  0  0  0
 50 51  1  0  0  0  0
 51 52  2  0  0  0  0
 52 53  1  0  0  0  0
 53 54  1  0  0  0  0
 53 55  1  6  0  0  0
 56 57  1  0  0  0  0
 56 58  1  1  0  0  0
 57 59  1  0  0  0  0
 57 60  2  0  0  0  0
 47 61  1  0  0  0  0
 47 62  1  6  0  0  0
 61 63  2  0  0  0  0
 59 64  1  0  0  0  0
 59 65  1  6  0  0  0
 65 66  1  0  0  0  0
 64 67  1  1  0  0  0
 64 63  1  0  0  0  0
 56 54  1  0  0  0  0
 63 68  1  0  0  0  0
M  END
>  <Catalog Number> (1)
A8169

>  <Item Name> (1)
Everolimus (RAD001)

>  <Formula> (1)
C53H83NO14

>  <MolWeight> (1)
958.22

>  <CAS Number> (1)
159351-69-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8169

$$$$

Untitled Document
  ChemDraw03202014252D
 18 19  0  0  0  0  0  0  0  0999 V2000
    0.9608   -1.2993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0087   -0.9873    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9387   -1.3022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5721   -1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6018   -1.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9814   -0.0618    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6532    0.4172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4053    1.2040    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5803    1.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3184    0.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9387   -0.4772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6532   -0.0647    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5721   -2.6338    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6018   -2.6320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1014    1.8832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4436    2.6338    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7199    1.8043    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4685    0.1812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  1      
  5  4  1  1      
  1  5  1  1      
  1  6  1  0      
  6  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
 10  6  1  0      
  3 11  1  0      
 11 12  1  0      
  4 13  1  0      
  5 14  1  0      
  9 15  1  0      
 15 16  2  0      
 15 17  1  0      
 10 18  1  0      
M  END
>  <Catalog Number> (1)
A8184

>  <Item Name> (1)
AICAR

>  <Formula> (1)
C9H14N4O5

>  <MolWeight> (1)
258.23

>  <CAS Number> (1)
2627-69-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8184

$$$$

Untitled Document
  ChemDraw02251413472D
 35 40  0  0  0  0  0  0  0  0999 V2000
    2.8184    2.5675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.2925    0.3329    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0519    1.8489    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5370    2.8009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3654   -1.5113    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6626    1.8670    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0998    2.3340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8872   -1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3574   -1.6015    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3300   -0.7258    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5370   -2.1030    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4580   -1.3516    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8197    2.6061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2241    1.3614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9427    1.5949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5383    2.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0560    1.6335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2131    0.8944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0853   -0.3214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1482   -1.0400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9034    0.5871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8244   -0.1643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5849    3.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3928   -0.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1207   -1.9157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8598   -2.0728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1319   -0.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0965   -1.4444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6021   -2.0059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3411   -1.8489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3686   -2.7245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8467   -2.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7189   -1.1945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8742   -3.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6132   -3.1290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  3  2  0      
  1  4  2  0      
  1  7  1  0      
  1 23  1  0      
  2 18  1  0      
 19  2  1  0      
  5 26  1  0      
 27  5  1  0      
  6 13  1  0      
  6 14  1  0      
  6 17  1  0      
  7 15  1  0      
 16  7  1  0      
  8 20  1  0      
  8 24  1  0      
  8 25  1  0      
  9 20  1  0      
 28  9  2  0      
 22 10  2  0      
 28 10  1  0      
 12 11  1  0      
 11 32  1  0      
 33 12  2  0      
 13 16  1  0      
 15 14  1  0      
 17 18  1  0      
 18 21  2  0      
 20 19  2  0      
 19 22  1  0      
 21 22  1  0      
 24 27  1  0      
 26 25  1  0      
 28 29  1  0      
 29 30  2  0      
 31 29  1  0      
 32 30  1  0      
 33 30  1  0      
 34 31  2  0      
 32 35  2  0      
 35 34  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
M  END
>  <Catalog Number> (1)
A8210

>  <Item Name> (1)
GDC-0941

>  <Formula> (1)
C23H27N7O3S2

>  <MolWeight> (1)
513.64

>  <CAS Number> (1)
957054-30-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8210

$$$$

Untitled Document
  ChemDraw02242016262D
 34 38  0  0  0  0  0  0  0  0999 V2000
   -4.2868    2.2687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.4437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.4437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.4437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.6812    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.4437    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.6812    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  4  7  1  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 10 11  2  0      
 11 12  1  0      
 12  7  2  0      
 10 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 11  1  0      
  5 17  1  6      
  9 18  1  0      
 18 19  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 23  1  0      
 23 18  1  0      
 23 24  1  1      
 15 25  1  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 29  2  0      
 29 30  1  0      
 30 25  2  0      
 27 31  1  0      
 31 32  1  0      
 33 34  1  0      
 34 28  1  0      
M  END
>  <Catalog Number> (1)
A8214

>  <Item Name> (1)
AZD8055

>  <Formula> (1)
C25H31N5O4

>  <MolWeight> (1)
465.54

>  <CAS Number> (1)
1009298-09-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8214

$$$$

Untitled Document
  ChemDraw07111410562D
 34 37  0  0  0  0  0  0  0  0999 V2000
   -0.9586   -3.1538    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    4.0663   -4.5273    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8546    1.8429    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3439   -4.5772    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8570    3.2719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6183    2.5595    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1360   -1.7233    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6135   -0.2985    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3415   -3.1483    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3747   -1.0110    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6110   -1.7275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8505    4.1635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1368    4.5772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5227    4.0262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6777    3.3567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4433    2.5581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2046    1.8457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6158    1.1304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1027   -2.4358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3795    1.8470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2777   -2.4372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2021    0.4167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5164   -3.1496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9658    1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3771    0.4181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9610   -1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1997   -1.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3723   -2.4399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7552   -3.8620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1973   -2.4413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5802   -3.8606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0640   -3.1923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8491   -3.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505   -4.2710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 28  1  0      
 31  2  1  0      
 34  2  1  0      
  3 16  2  0      
  4 29  2  0      
  5 14  1  0      
  5 15  1  0      
  5 16  1  0      
  6 16  1  0      
  6 17  1  0      
  7 21  1  0      
  7 26  1  0      
  8 22  1  0      
  8 27  1  0      
  9 23  1  0      
  9 29  1  0      
 26 10  2  0      
 27 10  1  0      
 11 27  2  0      
 30 11  1  0      
 13 12  1  0      
 12 15  1  0      
 14 13  1  0      
 17 18  1  0      
 17 20  2  0      
 18 22  2  0      
 19 21  1  0      
 19 23  1  0      
 24 20  1  0      
 22 25  1  0      
 25 24  2  0      
 26 28  1  0      
 28 30  2  0      
 29 31  1  0      
 31 32  2  0      
 32 33  1  0      
 33 34  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
M  END
>  <Catalog Number> (1)
A8222

>  <Item Name> (1)
BX795

>  <Formula> (1)
C23H26IN7O2S

>  <MolWeight> (1)
591.48

>  <CAS Number> (1)
702675-74-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8222

$$$$

Untitled Document
  ChemDraw06111414332D
 25 28  0  0  0  0  0  0  0  0999 V2000
   -1.2225   -0.7249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5080   -1.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6804   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5010   -2.0295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8357   -1.2755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6427   -1.1039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1284   -2.5572    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3087    0.0956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2456   -0.8018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6413    0.5805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7261    1.4004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4794    1.7368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1474    1.2526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0620    0.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4634    0.2171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4997    0.3249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9225   -0.6274    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1480   -1.3228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0815    1.0582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3744    1.9506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3752    2.0019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9201    1.1609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7295   -0.0529    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5657    2.5572    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7295   -0.7989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  1  1  0      
  5  6  2  0      
  3  7  2  0      
  1  8  1  0      
  2  9  1  0      
  8 10  2  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14  8  1  0      
  9 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  1  0      
 18  9  2  0      
 15 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 16  1  0      
 14 23  1  0      
 12 24  1  0      
 17 25  1  0      
M  END
>  <Catalog Number> (1)
A8240

>  <Item Name> (1)
SB 216763

>  <Formula> (1)
C19H12Cl2N2O2

>  <MolWeight> (1)
371.22

>  <CAS Number> (1)
280744-09-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8240

$$$$

Untitled Document
  ChemDraw02242016362D
 25 27  0  0  0  0  0  0  0  0999 V2000
   -1.0567   -0.7915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0504    0.0335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3793    0.5132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6282    1.2998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4531    1.3062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7140    0.5235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0207    0.7996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8554    1.6078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4727    2.1550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2553    1.8941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4206    1.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8033    0.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    0.2746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1381    1.9634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3455   -1.2095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3519   -2.0344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0694   -2.4414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7807   -2.0234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7743   -1.1985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4033    0.2523    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8725    2.4414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2032    0.8249    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.4856   -0.7805    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.4793    0.0445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2032   -1.1875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  2  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
 10 11  1  0      
 11 12  2  0      
 12  7  1  0      
  6 13  2  0      
  4 14  2  0      
  1 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19  1  1  0      
  3 20  1  0      
 20  7  1  0      
 10 21  1  0      
 11 22  1  0      
 19 23  1  0      
 23 24  2  0      
 23 25  1  0      
M  CHG  2  23   1  25  -1
M  STY  1   1 SUP
M  SLB  1   1   1
M  SAL   1  3  23  24  25
M  SBL   1  1  25
M  SMT   1 NO2
M  SBV   1  25    0.7113   -0.4180
M  END
>  <Catalog Number> (1)
A8241

>  <Item Name> (1)
SB 415286

>  <Formula> (1)
C16H10ClN3O5

>  <MolWeight> (1)
359.73

>  <CAS Number> (1)
264218-23-7

>  <Target> (1)
Stem Cell

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8241

$$$$

Untitled Document
  ChemDraw02251411502D
 36 41  0  0  0  0  0  0  0  0999 V2000
    1.0312    2.6887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1034    1.3116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1878    1.9376    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0189    0.0198    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3321   -2.6887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0189    1.7624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6785    0.7937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3487    1.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6785    0.0198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3464    1.1507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4182    2.0185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3487   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9245    0.6680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1675    0.8289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0083   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0189    0.7937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1073    0.4147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1714    1.7258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0083   -1.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7056    2.5128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6497    0.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9284    1.5649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3487   -1.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6785   -1.5279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7242   -0.0795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4717    0.1207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3381   -1.5279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3321   -1.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4717    1.2152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3381   -2.3018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0023   -1.5279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0023   -2.3018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6725   -1.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6725   -2.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3427   -1.5279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3427   -2.3018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 11  2  0      
  2  7  1  0      
  2 10  1  0      
  2 11  1  0      
  3  8  1  0      
 11  3  1  0      
  3 20  1  0      
  4 12  2  0      
 16  4  1  0      
 30  5  2  0      
 32  5  1  0      
  6 29  3  0      
  8  7  1  0      
  9  7  2  0      
  8 16  2  0      
 12  9  1  0      
 15  9  1  0      
 10 17  1  0      
 10 18  2  0      
 12 23  1  0      
 13 14  1  0      
 13 25  1  0      
 13 26  1  0      
 13 29  1  0      
 21 14  1  0      
 14 22  2  0      
 19 15  2  0      
 17 21  2  0      
 22 18  1  0      
 24 19  1  0      
 19 27  1  0      
 23 24  2  0      
 27 28  2  0      
 30 27  1  0      
 28 31  1  0      
 31 32  1  0      
 31 33  2  0      
 34 32  2  0      
 33 35  1  0      
 36 34  1  0      
 35 36  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
V   36 35
M  END
>  <Catalog Number> (1)
A8246

>  <Item Name> (1)
BEZ235 (NVP-BEZ235)

>  <Formula> (1)
C30H23N5O

>  <MolWeight> (1)
469.55

>  <CAS Number> (1)
915019-65-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8246

$$$$

Untitled Document
  ChemDraw07021415572D
 30 34  0  0  0  0  0  0  0  0999 V2000
    1.9199    1.5522    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6210    1.2761    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3310   -2.6012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7758    2.6814    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4297   -1.3607    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1521    1.2806    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9965   -0.2805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2909   -0.0401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0778    0.5000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2166   -0.8206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2100   -0.0226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1179   -2.0611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1922   -1.2806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7014    1.9008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9146    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9791   -0.7405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8402    0.5802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5685   -2.6814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6428   -1.9008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2264    2.0611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0133    2.6012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2341   -0.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3799   -0.9445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5096    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1298   -0.7851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1430   -1.6736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3502    1.0392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6428   -1.3548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6560   -2.2434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4059   -2.0840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 27  1  0      
  2 27  1  0      
  3 18  1  0      
 19  3  1  0      
  4 20  1  0      
 21  4  1  0      
  5 12  1  0      
  5 13  1  0      
  5 16  1  0      
  6 14  1  0      
  6 15  1  0      
  6 17  1  0      
  7 22  1  0      
  7 23  1  0      
 24  7  1  0      
  8 16  1  0      
 17  8  2  0      
  9 17  1  0      
 22  9  2  0      
 16 10  2  0      
 22 10  1  0      
 11 24  2  0      
 11 25  1  0      
 18 12  1  0      
 13 19  1  0      
 14 21  1  0      
 20 15  1  0      
 23 25  1  0      
 23 26  2  0      
 24 27  1  0      
 28 25  2  0      
 26 29  1  0      
 30 28  1  0      
 29 30  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
M  END
>  <Catalog Number> (1)
A8248

>  <Item Name> (1)
ZSTK474

>  <Formula> (1)
C19H21F2N7O2

>  <MolWeight> (1)
417.41

>  <CAS Number> (1)
475110-96-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8248

$$$$

Untitled Document
  ChemDraw02251414482D
 23 26  0  0  0  0  0  0  0  0999 V2000
   -2.4474    0.8074    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3496   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3496   -2.4223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0489   -0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0489    0.8074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7481   -0.4037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4474   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7481    1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3496   -0.4037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0489   -0.4037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0489   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3496   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7481   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3496   -1.6148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7481   -1.6148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7481    0.8074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4474   -0.4037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4474   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0489    1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4474    1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0489    2.0185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4474    2.0185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7481    2.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  7  1  0      
  8  1  1  0      
  9  2  1  0      
  2 10  1  0      
  3 14  2  0      
  4  5  1  0      
  4  6  1  0      
  4  9  1  0      
  5  8  1  0      
  7  6  1  0      
 12  9  2  0      
 10 11  1  0      
 10 13  2  0      
 14 11  1  0      
 11 15  2  0      
 14 12  1  0      
 13 16  1  0      
 17 13  1  0      
 15 18  1  0      
 16 19  1  0      
 16 20  2  0      
 18 17  2  0      
 19 21  2  0      
 22 20  1  0      
 21 23  1  0      
 23 22  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
M  END
>  <Catalog Number> (1)
A8250

>  <Item Name> (1)
LY 294002

>  <Formula> (1)
C19H17NO3

>  <MolWeight> (1)
307.34

>  <CAS Number> (1)
154447-36-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8250

$$$$

Untitled Document
  ChemDraw02242016422D
 27 30  0  0  0  0  0  0  0  0999 V2000
   -3.2014    2.3397    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9648   -0.2272    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0907    3.1572    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6152   -0.5033    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2013    0.5527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8558   -3.1572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1615   -0.7816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6661   -0.1289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5906    0.3213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2433    0.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4907   -0.1534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3929   -1.5735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1326    1.6435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0066    0.5129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8817   -0.8799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9243    0.5484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5487    1.8351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7853    2.1481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6593    1.0175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1771   -2.1699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1945   -1.7689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7065   -0.9045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7490    0.5239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1401   -0.2027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0543   -2.9617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4260   -2.5608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9648    2.0268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  3  2  0      
  1 17  1  0      
  1 27  1  0      
  2 24  1  0      
  7  4  1  0      
  9  4  2  0      
  8  5  1  0      
  5  9  1  0      
 25  6  1  0      
  6 26  2  0      
  7  8  2  0      
  7 12  1  0      
  8 11  1  0      
  9 10  1  0      
 10 13  2  0      
 10 14  1  0      
 11 15  2  0      
 11 16  1  0      
 12 20  1  0      
 21 12  2  0      
 13 18  1  0      
 19 14  2  0      
 15 22  1  0      
 23 16  2  0      
 18 17  2  0      
 17 19  1  0      
 20 25  2  0      
 21 26  1  0      
 22 24  2  0      
 24 23  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
M  END
>  <Catalog Number> (1)
A8254

>  <Item Name> (1)
SB 203580

>  <Formula> (1)
C21H16FN3OS

>  <MolWeight> (1)
377.44

>  <CAS Number> (1)
152121-47-6

>  <Target> (1)
MAPK Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8254

$$$$

Untitled Document
  ChemDraw02051421062D
 31 31  0  0  0  0  0  0  0  0999 V2000
   -4.1921    1.7028    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1921    2.4718    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4231    1.7028    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9612    1.7028    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.1921    0.9337    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1902    3.6254    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.5242    4.0099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1902    2.8564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8581    2.8564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8581    3.6254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5242    2.4718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5747    4.2914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9592    3.6254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0385    1.0367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1913   -0.9613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5758   -1.6273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4222   -0.9613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0377   -0.2953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3449   -1.6273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7313   -0.2953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2695    1.0367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1159    0.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7294   -2.2934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8849    0.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4985   -2.2934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8830   -2.9594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6521   -2.9594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0366   -3.6254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8057   -3.6254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1902   -4.2914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9592   -4.2914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  1  3  1  6      
  1  4  1  6      
  1  5  2  0      
  2  9  1  0      
  3 14  1  0      
  6  7  1  0      
  6  8  1  0      
  6 12  1  0      
  6 13  1  0      
  7 10  1  0      
 11  8  1  0      
 10  9  1  0      
  9 11  1  0      
 14 21  1  0      
 15 16  1  0      
 15 17  1  0      
 16 19  1  0      
 17 18  1  0      
 18 20  1  0      
 19 23  1  0      
 20 22  1  0      
 21 24  1  0      
 22 24  1  0      
 23 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 28  1  0      
 28 29  1  0      
 29 30  1  0      
 30 31  1  0      
M  CHG  2   4  -1   6   1
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
M  END
>  <Catalog Number> (1)
A8309

>  <Item Name> (1)
Perifosine

>  <Formula> (1)
C25H52NO4P

>  <MolWeight> (1)
461.67

>  <CAS Number> (1)
157716-52-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8309

$$$$

Untitled Document
  ChemDraw02251418022D
 45 51  0  0  0  0  0  0  0  0999 V2000
   -0.6606    2.6699    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3212    2.2884    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3212    1.5256    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6425   -1.5256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3212    3.0513    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6606    0.3814    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9819   -0.3814    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9819    1.9070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9637    0.7628    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -0.7628    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6606   -0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3212    0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3212   -0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9819    0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6425   -0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6606    0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3212    1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6606    1.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3212    0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3031   -0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6606    1.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3031    1.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9819    2.6699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9637   -0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3031    0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9819    0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3031    2.6699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    3.0513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9819   -0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9637    1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3031   -0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425   -0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3212   -0.7628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3212   -1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6606   -0.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6606   -1.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6606   -2.6699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6606   -1.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.0513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6606   -2.6699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 24  1  0      
  2 24  1  0      
  3 24  1  0      
  4 17  2  0      
  5 27  2  0      
  6 11  1  0      
  6 12  1  0      
  6 15  1  0      
 13  7  1  0      
  7 14  1  0      
  7 17  1  0      
  8 19  1  0      
 23  8  1  0      
 27  8  1  0      
  9 29  2  0      
 34  9  1  0      
 39 10  2  0      
 41 10  1  0      
 11 13  1  0      
 14 12  1  0      
 15 16  1  0      
 15 18  2  0      
 16 20  2  0      
 16 24  1  0      
 17 22  1  0      
 21 18  1  0      
 20 19  1  0      
 19 21  2  0      
 22 28  1  0      
 25 23  2  0      
 26 23  1  0      
 29 25  1  0      
 30 25  1  0      
 31 26  1  0      
 26 34  2  0      
 27 32  1  0      
 29 35  1  0      
 33 30  2  0      
 32 31  2  0      
 36 33  1  0      
 33 37  1  0      
 35 36  2  0      
 37 38  2  0      
 39 37  1  0      
 38 40  1  0      
 40 41  1  0      
 40 42  2  0      
 43 41  2  0      
 42 44  1  0      
 45 43  1  0      
 44 45  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
V   36 35
V   37 36
V   38 37
V   39 38
V   40 39
V   41 40
V   42 41
V   43 42
V   44 43
V   45 44
M  END
>  <Catalog Number> (1)
A8312

>  <Item Name> (1)
Torin 1

>  <Formula> (1)
C35H28F3N5O2

>  <MolWeight> (1)
607.64

>  <CAS Number> (1)
1222998-36-8

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8312

$$$$

Untitled Document
  ChemDraw03202010412D
 73 76  0  0  0  0  0  0  0  0999 V2000
    0.6871    0.7233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0004    1.1804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0529    2.0028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6358    2.4612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7397    0.8139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5831    3.2858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2751    3.7465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0208    3.3772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0739    2.5462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3805    2.0846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8074    2.1800    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7032    3.8288    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4473    3.4632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1296    3.9175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8614    1.3538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4979    2.6338    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8737    3.5489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5658    4.5113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6335    4.5681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7990    5.3012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5471    3.9952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4264    1.0894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1131    0.6322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8523    0.9983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0617   -0.1925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5391    0.5411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6888   -0.1057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0274   -0.5171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7397   -0.1046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4587    1.1372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1756    0.7233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1756   -0.1046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4584   -0.5196    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7992    1.3947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0254   -1.3446    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4587   -1.3463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7424   -1.7614    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1732   -1.7588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8847   -1.3475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1732   -2.5838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8901   -2.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8901   -3.8255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1732   -4.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4562   -3.8255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4535   -3.0003    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8897   -2.1724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6045   -2.5853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7418   -4.2380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0005   -3.8780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6834   -4.3409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4257   -3.9809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1086   -4.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8508   -4.0838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5337   -4.5467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2760   -4.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049    1.8216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4864   -0.2821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732   -0.7393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7472   -0.6482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9141   -0.3756    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1206   -1.5626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8073   -2.0198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7548   -2.8431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4414   -3.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3840   -1.9315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6947   -1.4716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5471   -1.6545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0155   -3.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0613   -3.0569    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6230   -2.5924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6240   -5.1637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0238   -4.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3462   -5.3012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  4  3  1  1      
  4  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10  4  1  0      
  9 11  1  1      
  8 12  1  6      
 12 13  1  0      
 13 14  1  0      
 11 15  1  0      
 13 16  2  0      
 14 17  1  0      
 14 18  1  0      
 14 19  1  0      
 18 20  1  0      
 17 21  1  0      
  1 22  1  0      
 22 23  1  0      
 23 24  1  0      
 23 25  2  0      
 24 26  1  0      
  1 27  1  6      
 27 28  1  0      
 29 28  1  1      
 29  5  1  0      
  5 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 33  1  0      
 33 29  1  0      
  2 34  1  6      
 28 35  2  0      
 33 36  1  0      
 36 37  2  0      
 36 38  1  0      
 38 39  2  0      
 38 40  1  0      
 40 41  1  0      
 41 42  1  0      
 42 43  1  0      
 43 44  1  0      
 44 45  1  0      
 45 40  1  0      
 40 46  1  1      
 41 47  1  1      
 44 48  1  6      
 48 49  1  0      
 49 50  1  0      
 50 51  2  0      
 51 52  1  0      
 52 53  2  0      
 53 54  1  0      
 54 55  2  0      
 24 56  1  6      
 26 57  2  0      
 57 58  1  0      
 57 59  1  0      
 58 60  1  1      
 58 61  1  0      
 61 62  1  0      
 62 63  1  0      
 63 64  1  0      
 61 65  1  6      
 65 66  1  0      
 62 67  2  0      
 63 68  1  1      
 49 69  1  6      
 69 70  1  0      
 50 71  1  0      
 55 72  1  0      
 64 72  1  0      
 72 73  1  6      
M  END
>  <Catalog Number> (1)
A8314

>  <Item Name> (1)
Temsirolimus

>  <Formula> (1)
C56H87NO16

>  <MolWeight> (1)
1030.29

>  <CAS Number> (1)
162635-04-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8314

$$$$

Untitled Document
  ChemDraw02251415072D
 30 35  0  0  0  0  0  0  0  0999 V2000
    0.0891   -0.6538    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5479    0.3017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2608    0.2086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9833    2.4324    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0231    0.6258    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5447    1.2050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2640   -0.1155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2608    0.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0264   -0.2776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3071    1.0429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5447   -0.2086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0231    0.3706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3038   -0.9498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5414   -1.1119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3006   -1.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2640    1.1119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4788   -1.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0199    1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7425    1.6911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7197   -1.1119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3071   -0.0465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8253   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8221   -2.4324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0264    1.2739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5845   -2.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5479    0.6947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0004   -2.4324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4821   -0.9498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7627   -2.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0036   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 14  1  0      
 20  1  1  0      
  2  9  1  0      
 10  2  1  0      
  8  3  1  0      
  3 12  1  0      
  4 19  2  0      
  5  6  1  0      
  5  7  1  0      
  5  8  1  0      
  6 10  1  0      
  9  7  1  0      
 18  8  2  0      
 12 11  1  0      
 11 13  1  0      
 21 11  2  0      
 12 16  2  0      
 14 13  1  0      
 13 22  2  0      
 14 15  2  0      
 17 15  1  0      
 23 15  1  0      
 19 16  1  0      
 16 24  1  0      
 17 20  1  0      
 27 17  2  0      
 19 18  1  0      
 20 28  2  0      
 26 21  1  0      
 22 25  1  0      
 25 23  2  0      
 24 26  2  0      
 29 27  1  0      
 30 28  1  0      
 30 29  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
M  END
>  <Catalog Number> (1)
A8315

>  <Item Name> (1)
NU7441 (KU-57788)

>  <Formula> (1)
C25H19NO3S

>  <MolWeight> (1)
413.49

>  <CAS Number> (1)
503468-95-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8315

$$$$

Untitled Document
  ChemDraw02251416582D
 23 26  0  0  0  0  0  0  0  0999 V2000
   -2.5283   -2.6694    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4904    0.7366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0278    0.1000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1915    2.1429    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1055    0.1238    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1417    2.4263    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0537    1.4134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2773    0.7366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2795    0.3431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2795    1.1300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0278    1.3732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.1194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    0.0551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    1.4181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3053    1.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1055   -1.1495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5681   -0.5128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6067    2.6694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4256   -1.8683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3507   -0.5951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2082   -1.9506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6707   -1.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 22  1  0      
  2  3  1  0      
  2  8  1  0      
 11  2  1  0      
  3  9  1  0      
  4 11  2  0      
 19  4  1  0      
  5 12  1  0      
 18  5  2  0      
 15  6  1  0      
  6 19  2  0      
  7 15  1  0      
  8 13  1  0      
  8 14  1  0      
  9 10  1  0      
  9 12  2  0      
 11 10  1  0      
 15 10  2  0      
 16 12  1  0      
 16 17  2  0      
 17 18  1  0      
 17 20  1  0      
 21 18  1  0      
 20 22  2  0      
 23 21  2  0      
 22 23  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
M  END
>  <Catalog Number> (1)
A8318

>  <Item Name> (1)
PP242

>  <Formula> (1)
C16H16N6O

>  <MolWeight> (1)
308.35

>  <CAS Number> (1)
1092351-67-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8318

$$$$

Untitled Document
  ChemDraw02081416132D
 39 44  0  0  0  0  0  0  0  0999 V2000
   -0.7887   -1.0246    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3380    2.3907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9437    0.3415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9718   -1.7077    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9718    1.0246    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1549   -3.7569    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7606    2.3907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7887    1.7077    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1549   -1.0246    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1549    1.7077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1549    3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9437    3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9437    1.7077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9718    2.3907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3380    1.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3380    3.7569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5775    1.7077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7887   -1.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3944   -0.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3944   -1.7077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3944    1.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9437   -1.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7606   -0.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3944   -1.7077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3944   -0.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7887    0.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7887   -2.3907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3380   -0.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1549    0.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7606   -1.7077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5775   -2.3907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3944    1.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7887    0.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7887   -2.3907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3944   -3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3944   -3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1549   -2.3907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9718   -3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7606   -3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 24  1  0      
 25  1  1  0      
  2 12  1  0      
  2 13  1  0      
  3 28  1  0      
 29  3  1  0      
 30  4  1  0      
 31  4  1  0      
  5 17  2  0      
  6 39  2  0      
  7 10  1  0      
  7 11  1  0      
  7 14  1  0      
  8 17  1  0      
  8 21  1  0      
  9 22  1  0      
  9 23  1  0      
  9 30  1  0      
 10 13  1  0      
 11 12  1  0      
 12 16  1  6      
 13 15  1  6      
 14 17  1  0      
 18 19  1  0      
 18 20  1  0      
 19 25  1  0      
 19 26  2  0      
 24 20  1  0      
 34 20  2  0      
 26 21  1  0      
 21 32  2  0      
 28 22  1  0      
 23 29  1  0      
 24 27  2  0      
 33 25  2  0      
 27 31  1  0      
 27 35  1  0      
 30 37  2  0      
 38 31  2  0      
 32 33  1  0      
 36 34  1  0      
 35 36  2  0      
 37 39  1  0      
 39 38  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
V   36 35
V   37 36
V   38 37
V   39 38
M  END
>  <Catalog Number> (1)
A8336

>  <Item Name> (1)
KU-60019

>  <Formula> (1)
C30H33N3O5S

>  <MolWeight> (1)
547.68

>  <CAS Number> (1)
925701-49-1

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8336

$$$$

Untitled Document
  ChemDraw02131415342D
 30 32  0  0  0  0  0  0  0  0999 V2000
   -0.2137   -0.1785    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6260   -0.1355    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0033    0.5181    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6260    1.1717    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3103    2.1173    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3103   -1.0256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8420    0.1685    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5420    0.0319    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5420    1.0598    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4939   -0.7890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9314   -1.1664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8420    0.9232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5597    1.1564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0033    0.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5597   -0.0647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2314    1.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2314   -0.2751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4939    0.5181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1166   -0.1355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2486    0.5181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8404    0.8954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4939    1.2728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3619   -0.1355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9846   -0.7890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9314   -0.4117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2299   -0.7890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2137   -1.3996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3619   -1.4426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1166   -1.4426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0195   -2.1173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 25  1  0      
 26  1  1  0      
  2 20  1  0      
  3 20  1  0      
  4 20  1  0      
  5 16  2  0      
  6 17  2  0      
  7 12  1  0      
  7 15  1  0      
  7 17  1  0      
  8 17  1  0      
  8 25  1  0      
  9 16  1  0      
 19 10  2  0      
 10 29  1  0      
 25 11  2  0      
 27 11  1  0      
 12 13  1  0      
 12 16  1  1      
 13 14  1  0      
 14 15  1  0      
 18 19  1  0      
 18 20  1  0      
 18 21  1  0      
 18 22  1  0      
 23 19  1  0      
 24 23  2  0      
 24 26  1  0      
 28 24  1  0      
 27 26  2  0      
 27 30  1  0      
 28 29  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
M  END
>  <Catalog Number> (1)
A8346

>  <Item Name> (1)
BYL-719

>  <Formula> (1)
C19H22F3N5O2S

>  <MolWeight> (1)
441.47

>  <CAS Number> (1)
1217486-61-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8346

$$$$

Untitled Document
  ChemDraw02181413222D
 11 12  0  0  0  0  0  0  0  0999 V2000
   -0.7145   -0.8591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3276    0.5179    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.8591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1715    1.1854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.3784    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.0341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.0341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.2716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.2716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9920    1.2716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  6  1  1  0      
  9  1  1  0      
  1 10  1  0      
  2  6  2  0      
 11  2  1  0      
  3  8  1  0      
  9  3  2  0      
  7  4  1  0      
  4 11  2  0      
  5  8  1  0      
  7  6  1  0      
  8  7  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
M  END
>  <Catalog Number> (1)
A8353

>  <Item Name> (1)
3-Methyladenine

>  <Formula> (1)
C6H7N5

>  <MolWeight> (1)
149.15

>  <CAS Number> (1)
5142-23-4

>  <Target> (1)
Ubiquitination/Proteasome

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8353

$$$$

Untitled Document
  ChemDraw02181413452D
 26 28  0  0  0  0  0  0  0  0999 V2000
    2.6226    0.2209    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.2280   -0.3444    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7013    0.2568    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9245   -2.1888    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0133   -1.5602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9245   -0.9316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5056   -0.1317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5056    0.5838    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2280   -1.5188    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4399   -0.9730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1302   -1.1973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1302   -1.9231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4399   -2.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2156   -0.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2874   -1.5602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4202    1.4985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1959    0.8082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9345    2.0379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6445    2.1888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1302    1.6494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1986   -0.9316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5056   -0.1420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9184   -0.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9184   -1.2945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1959   -0.3663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5056   -1.7212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 17  1  0      
 25  1  1  0      
  2 21  1  0      
 23  2  1  0      
  3 14  2  0      
  4 15  2  0      
  5 10  1  0      
  5 13  1  0      
  5 15  1  0      
  6 15  1  0      
  6 21  1  0      
  7 14  1  0      
 17  8  2  0      
 22  8  1  0      
 21  9  2  0      
 24  9  1  0      
 10 11  1  0      
 10 14  1  1      
 11 12  1  0      
 12 13  1  0      
 16 17  1  0      
 16 18  1  0      
 16 19  1  0      
 16 20  1  0      
 22 23  1  0      
 22 25  2  0      
 24 23  2  0      
 24 26  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
M  END
>  <Catalog Number> (1)
A8354

>  <Item Name> (1)
A66

>  <Formula> (1)
C17H23N5O2S2

>  <MolWeight> (1)
393.53

>  <CAS Number> (1)
1166227-08-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8354

$$$$

Untitled Document
  ChemDraw02242016072D
 34 38  0  0  1  0  0  0  0  0999 V2000
   -2.6812   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2687   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4437   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0312   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4437    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2687    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6812    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2688    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5062    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9188    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2062   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2063   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0313   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4438   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0313    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2063    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2688   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6813    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2688    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4438    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4438   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2688   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6813   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6813   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5063   -2.8579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9188   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5063   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6813    1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5063    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9188    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5063    2.8579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6813    2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2688    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4438    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  6  7  1  0      
  7  8  2  0      
  7  9  1  0      
  9 10  1  0      
  4 11  1  0      
 11 12  1  0      
 12 13  2  0      
 13 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 11  2  0      
 14 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 20 15  1  0      
 22 21  1  6      
 22 23  1  0      
 23 17  1  0      
 22 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 23  1  0      
 19 28  1  0      
 28 29  1  0      
 29 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 33  1  0      
 33 28  1  0      
 33 34  1  1      
M  END
>  <Catalog Number> (1)
A8373

>  <Item Name> (1)
AZD2014

>  <Formula> (1)
C25H30N6O3

>  <MolWeight> (1)
462.54

>  <CAS Number> (1)
1009298-59-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8373

$$$$

Untitled Document
  ChemDraw07021416412D
 33 36  0  0  0  0  0  0  0  0999 V2000
    1.7862    0.2898    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.6441    0.2898    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -4.6441    2.3523    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.9296    3.5898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.9477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -2.5977    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    1.1148    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.9477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -2.1852    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    1.1148    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3939   -3.5898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9296    2.7648    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.9296    1.1148    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.1227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    0.2898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -1.3602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -2.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -0.9477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -1.3602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -2.5977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    1.5273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -0.1227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151   -1.3602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2543   -2.2622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5869   -3.4182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    2.3523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151    0.2898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9296   -0.9477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9296   -0.1227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8064   -2.8753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151    2.3523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    2.7648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151    1.5273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 22  1  0      
  2 29  1  0      
  3 12  1  0      
  4 12  2  0      
  5 14  1  0      
  5 19  1  0      
  6 17  1  0      
 24  6  1  0      
 25  6  1  0      
  7 15  1  0      
  7 21  1  0      
 16  8  2  0      
 19  8  1  0      
  9 19  2  0      
 20  9  1  0      
 21 10  2  0      
 10 33  1  0      
 11 25  2  0      
 30 11  1  0      
 12 31  1  0      
 13 33  1  0      
 14 15  1  0      
 16 17  1  0      
 16 18  1  0      
 17 20  2  0      
 18 22  1  0      
 18 23  2  0      
 26 21  1  0      
 22 27  2  0      
 28 23  1  0      
 24 30  2  0      
 32 26  2  0      
 27 29  1  0      
 29 28  2  0      
 31 32  1  0      
 31 33  2  0      
M  CHG  2   3  -1  12   1
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
M  END
>  <Catalog Number> (1)
A8395

>  <Item Name> (1)
CHIR-98014

>  <Formula> (1)
C20H17Cl2N9O2

>  <MolWeight> (1)
486.31

>  <CAS Number> (1)
252935-94-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8395

$$$$

Untitled Document
  ChemDraw03202009432D
 33 35  0  0  0  0  0  0  0  0999 V2000
    1.0647    0.4276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0647   -0.3974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7792   -0.8099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4937   -0.3974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4937    0.4276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7792    0.8401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2057    0.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2057   -0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3528    0.8387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3593    0.4276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0713    0.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7833    0.4276    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4953    0.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4953    1.6637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2098    2.0762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9243    1.6637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9243    0.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2098    0.4262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6362    2.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3467    2.4844    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2919   -1.6290    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0989   -1.8005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5114   -1.0860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9594   -0.4729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9202    0.4262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6347    0.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6347    1.6637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9202    2.0762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2057    1.6637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3291   -1.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3467    2.0748    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.4937    2.0748    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.4182   -2.4844    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  5  7  1  0      
  4  8  1  0      
  1  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 13  1  0      
 16 19  1  0      
 19 20  3  0      
  8 21  1  0      
 21 22  1  0      
 22 23  2  0      
 23 24  1  0      
 24  8  2  0      
  7 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 29  2  0      
 29  7  1  0      
 23 30  1  0      
 27 31  1  0      
 29 32  1  0      
M  END
>  <Catalog Number> (1)
A8396

>  <Item Name> (1)
CHIR-99021 (CT99021) HCl

>  <Formula> (1)
C22H18Cl2N8.HCl

>  <MolWeight> (1)
501.8

>  <CAS Number> (1)
1797989-42-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8396

$$$$

Untitled Document
  ChemDraw03202009282D
 47 51  0  0  0  0  0  0  0  0999 V2000
    2.9414    1.2716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5289    1.9861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9414    2.7005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7664    2.7005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5289    0.5571    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7664    1.2716    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1789    1.9861    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1789    3.4150    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5369   -3.4150    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2513   -3.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2513   -2.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5369   -1.7650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8224   -2.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1079   -1.7650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6065   -2.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6065   -3.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1079   -3.4150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8224   -3.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5289   -0.8718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8644   -1.6255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7084   -0.9581    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9414   -0.1573    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1564   -0.3450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4113    0.4397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8593    1.0528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0523    0.8812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2026    0.0966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3494   -0.5165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1142    1.8374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3692    2.6220    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.3296    2.0923    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8988    1.5824    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4997    1.4943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2448    2.2789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7968    2.8920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6038    2.7205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8588    1.9359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3067    1.3228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6714   -1.7970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3210   -0.9400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3210   -1.7650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0355   -2.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7499   -1.7650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7499   -0.9400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0355   -0.5275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4644   -0.5275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1789   -0.9400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  1  5  2  0      
  1  6  1  0      
  4  7  2  0      
  4  8  1  0      
  9 10  2  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  2  0      
  9 18  1  0      
 13 18  1  0      
 19 20  1  0      
 19 21  1  0      
 11 20  1  0      
 12 21  1  0      
 19 22  2  0      
 23 24  1  0      
 24 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 23 28  2  0      
 29 30  1  0      
 29 31  1  0      
 29 32  1  0      
 25 29  1  0      
 33 34  1  0      
 34 35  1  0      
 35 36  1  0      
 36 37  1  0      
 37 38  1  0      
 33 38  1  0      
 26 33  1  0      
 21 23  1  0      
 20 39  1  0      
 40 41  1  0      
 41 42  2  0      
 42 43  1  0      
 43 44  2  0      
 44 45  1  0      
 40 45  2  0      
 46 47  1  0      
 44 46  1  0      
 15 41  1  0      
M  END
>  <Catalog Number> (1)
A8488

>  <Item Name> (1)
NVP-BGT226

>  <Formula> (1)
C28H25F3N6O2.C4H4O4

>  <MolWeight> (1)
650.6

>  <CAS Number> (1)
1245537-68-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8488

$$$$

Untitled Document
  ChemDraw02182014112D
 31 34  0  0  0  0  0  0  0  0999 V2000
    1.7984   -2.8273    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3888    0.0272    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8679    3.3050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0843   -1.2210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7798   -2.4693    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2085   -2.4911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4753   -3.7175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1346    2.0785    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3636   -1.6226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3510   -2.4475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3445   -1.1993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0778   -2.4257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3697   -2.8491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0652   -1.6008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7924   -1.6444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0969   -0.3961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5130   -1.2428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8175    0.0054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5256   -0.4179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2211   -1.6662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8301    0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4879   -2.8926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9418   -1.2646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5508    1.2319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1220    1.2536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5634    2.0568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8553    2.4801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5823    3.7175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5129   -2.4148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2273   -2.8273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9418   -2.4148    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 12  1  1  6      
  2 16  2  0      
  3 27  1  0      
  9  4  1  6      
  4 15  1  0      
  4 16  1  0      
  5 15  2  0      
 22  5  1  0      
 20  6  1  0      
  6 22  2  0      
  7 22  1  0      
 25  8  2  0      
  8 27  1  0      
  9 10  1  0      
  9 11  1  0      
 10 13  1  0      
 14 11  1  0      
 13 12  1  0      
 12 14  1  0      
 17 15  1  0      
 16 18  1  0      
 19 17  1  0      
 17 20  2  0      
 18 19  2  0      
 18 21  1  0      
 20 23  1  0      
 24 21  2  0      
 21 25  1  0      
 26 24  1  0      
 26 27  2  0      
  3 28  1  0      
  1 29  1  0      
 29 30  1  0      
 30 31  1  0      
M  END
>  <Catalog Number> (1)
A8499

>  <Item Name> (1)
PF-04691502

>  <Formula> (1)
C22H27N5O4

>  <MolWeight> (1)
425.48

>  <CAS Number> (1)
1013101-36-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8499

$$$$

Untitled Document
  ChemDraw02182015252D
 42 47  0  0  0  0  0  0  0  0999 V2000
   -1.1527   -4.9903    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9191   -3.5291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8611   -2.1013    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3231   -2.1731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0686   -1.3373    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7031   -3.3552    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4426   -2.9894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4799    1.4179    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3602   -4.2263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0948   -3.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7116   -4.2931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9770   -4.9569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3023   -2.7985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1266   -2.7650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5098   -2.0344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2443   -1.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9133   -1.5966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8033   -0.6736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1864    0.0570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9789   -0.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9210    0.7208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7453    0.7542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5378   -0.0098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7076   -1.8194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3451    1.4179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7576    2.1324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7576    0.7035    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5826    2.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9951    1.4179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8201    1.4179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2326    2.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8201    2.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9951    2.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0576    2.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701    2.8469    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701    1.4179    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2951    2.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7076    3.5614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2951    4.2758    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701    4.2758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0576    3.5614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7076    4.9903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 11  1  0      
 12  1  1  0      
  2  9  1  0      
  2 10  1  0      
  2 13  1  0      
 13  3  2  0      
  3 16  1  0      
  4  7  1  0      
 15  4  1  0      
  4 17  1  0      
  5 15  1  0      
 16  5  2  0      
  7  6  2  0      
  6 14  1  0      
  8 21  1  0      
  9 12  1  0      
 11 10  1  0      
 13 14  1  0      
 15 14  2  0      
 16 18  1  0      
 18 19  1  0      
 18 20  2  0      
 19 22  2  0      
 23 20  1  0      
 22 21  1  0      
 21 23  2  0      
 17 24  1  0      
  8 25  1  0      
 25 26  1  0      
 25 27  2  0      
 26 28  1  0      
 28 29  1  0      
 29 30  2  0      
 30 31  1  0      
 31 32  2  0      
 32 33  1  0      
 33 28  2  0      
 31 34  1  0      
 34 35  1  0      
 34 36  2  0      
 35 37  1  0      
 37 38  1  0      
 38 39  1  0      
 39 40  1  0      
 40 41  1  0      
 41 35  1  0      
 39 42  1  0      
M  END
>  <Catalog Number> (1)
A8505

>  <Item Name> (1)
PKI-402

>  <Formula> (1)
C29H34N10O3

>  <MolWeight> (1)
570.65

>  <CAS Number> (1)
1173204-81-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8505

$$$$

Untitled Document
  ChemDraw02182017372D
 23 26  0  0  1  0  0  0  0  0999 V2000
   -1.0020   -0.2474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0535    0.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0517    2.2031    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7782    1.8124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3766    2.1601    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3270    0.5109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1774   -0.2226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6252    0.9447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1013    0.5539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6500    1.7693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8030    0.9877    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0783    1.7263    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4014    2.9847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7552    0.4678    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3074   -0.8901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0523   -1.6747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7197   -2.1597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3872   -1.6747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1324   -0.8901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7323   -1.9295    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7196   -2.9847    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1718   -1.9297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7552   -1.3463    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  6  2  0      
  1  7  1  0      
  2  6  1  0      
 12  2  2  0      
  4  3  2  0      
  3 10  1  0      
 11  4  1  0      
 10  5  1  0      
  5 12  1  0      
  6  8  1  0      
  7  9  1  0      
  9  8  1  0      
 10  8  2  0      
  9 11  2  0      
  5 13  1  0      
  2 14  1  0      
 15  7  1  6      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 15  1  0      
 16 20  1  1      
 17 21  1  1      
 18 22  1  6      
 22 23  1  0      
M  END
>  <Catalog Number> (1)
A8541

>  <Item Name> (1)
Triciribine

>  <Formula> (1)
C13H16N6O4

>  <MolWeight> (1)
320.3

>  <CAS Number> (1)
35943-35-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8541

$$$$

Untitled Document
  ChemDraw07031411472D
 31 35  0  0  0  0  0  0  0  0999 V2000
   -0.6083    0.7269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2053    1.0759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8956   -1.1218    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4144   -1.3402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6008   -2.0653    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0038    1.7740    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4144    1.0759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8173    0.7269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2128   -1.0182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6083   -1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0038   -0.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2128   -0.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6008    0.0289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0038   -1.0182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6083    0.0289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7534   -2.0500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7316   -1.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4476   -2.1230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8505   -0.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2053   -0.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6008    0.7269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6008   -1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2053   -1.0182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0038    0.3779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8098    0.0289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0038    1.0759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8098    0.7269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2447   -0.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2128    1.0759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2128    1.7740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6083    2.1230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 15  1  1  1      
  1 29  1  0      
  2 21  1  0      
  2 27  1  0      
  3 23  1  0      
  3 28  1  0      
  4 17  2  0      
  5 22  2  0      
  6 26  1  0      
  6 31  1  0      
  7 27  2  0      
  8 29  2  0      
  9 10  1  0      
  9 12  1  0      
  9 17  1  0      
  9 19  1  6      
 10 14  1  0      
 10 16  1  6      
 11 13  1  0      
 11 14  2  0      
 11 15  1  0      
 12 15  1  0      
 13 20  1  0      
 13 21  1  0      
 13 24  1  6      
 14 22  1  0      
 16 18  1  0      
 17 18  1  0      
 20 23  2  0      
 20 25  1  0      
 21 26  1  1      
 22 23  1  0      
 25 27  1  0      
 25 28  2  0      
 29 30  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
M  END
>  <Catalog Number> (1)
A8544

>  <Item Name> (1)
Wortmannin

>  <Formula> (1)
C23H24O8

>  <MolWeight> (1)
428.43

>  <CAS Number> (1)
19545-26-7

>  <Target> (1)
Ubiquitination/Proteasome

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8544

$$$$

Untitled Document
  ChemDraw02192011262D
 23 26  0  0  0  0  0  0  0  0999 V2000
   -1.7989   -0.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9828   -0.7706    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6331    0.6054    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8674    1.8119    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4398    1.7521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3761   -1.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2055    0.5456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9365    0.1634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6159   -0.0316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1975    0.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1543   -2.0341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1752   -1.0344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1709    1.3699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7233   -0.5297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4851    0.8793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5368   -0.3921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8243    0.3812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2985    1.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5985    1.4297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5914    0.6849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5395    1.5082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7405    1.7134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1752    2.0341    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  1  6  1  0      
  1  8  1  0      
  2  9  2  0      
  3  8  2  0      
 19  3  1  0      
 13  4  1  0      
  4 19  2  0      
  5 13  1  0      
  6 11  1  0      
  6 12  1  0      
  7  8  1  0      
  9  7  1  0      
  7 13  2  0      
  9 10  1  0      
 10 14  1  0      
 10 15  2  0      
 16 14  2  0      
 15 18  1  0      
 17 16  1  0      
 18 17  2  0      
 17 20  1  0      
 20 21  1  0      
 21 22  2  0      
 22 18  1  0      
 21 23  1  0      
M  END
>  <Catalog Number> (1)
A8551

>  <Item Name> (1)
INK 128 (MLN0128)

>  <Formula> (1)
C15H15N7O

>  <MolWeight> (1)
309.33

>  <CAS Number> (1)
1224844-38-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8551

$$$$

Untitled Document
  ChemDraw07031411502D
 36 40  0  0  0  0  0  0  0  0999 V2000
   -0.6031   -0.6801    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6031   -2.2508    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3236   -2.2508    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.5749   -2.7205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0770   -0.2875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9958    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2104   -1.3603    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3236    2.0404    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7529   -2.0404    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2104    2.7205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6031    2.0404    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7529   -0.6801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7529    0.6801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9310    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7529    2.0404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5749   -1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9676   -0.6801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9310    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3236    0.6801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456   -1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2832   -1.0728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9676    2.0404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9676   -2.0404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456    2.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9310    2.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2832   -1.8582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9634   -0.6801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5749    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5749    2.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9634   -2.2508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6435   -1.0728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6435   -1.8582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2104    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2104   -2.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  5  2  0      
  1  6  2  0      
  1  7  1  0      
  1 23  1  0      
  2 28  1  0      
  3 34  1  0      
  4 25  1  0      
  4 36  1  0      
  7 18  1  0      
 16  8  1  0      
 27  8  2  0      
 22  9  2  0      
  9 25  1  0      
 11 10  1  0      
 10 31  2  0      
 35 11  2  0      
 12 15  2  0      
 12 16  1  0      
 17 12  1  0      
 13 14  1  0      
 15 13  1  0      
 13 20  2  0      
 19 14  2  0      
 14 22  1  0      
 21 16  2  0      
 17 24  1  0      
 26 17  2  0      
 18 19  1  0      
 18 25  2  0      
 20 21  1  0      
 23 28  1  0      
 23 29  2  0      
 24 30  2  0      
 24 31  1  0      
 27 26  1  0      
 28 32  2  0      
 33 29  1  0      
 30 35  1  0      
 32 34  1  0      
 34 33  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
V   36 35
M  END
>  <Catalog Number> (1)
A8556

>  <Item Name> (1)
GSK2126458

>  <Formula> (1)
C25H17F2N5O3S

>  <MolWeight> (1)
505.5

>  <CAS Number> (1)
1086062-66-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8556

$$$$

Untitled Document
  ChemDraw07031413192D
 27 30  0  0  0  0  0  0  0  0999 V2000
   -0.6811    0.3753    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1438    1.8639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5784   -2.9233    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6618   -2.1299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7218   -1.7349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7078    1.2998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4784    1.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4613    0.5411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6848    2.2768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3993   -2.3983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3725   -1.4738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9331   -1.8055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6190   -2.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5922   -1.3079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982   -3.0891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4345   -0.3834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9063   -0.8809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6866   -1.0468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3457   -0.5492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4554    2.4833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1208    2.8409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4737   -3.8179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0585   -1.9007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9683   -0.9762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6618    3.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3272    3.6114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0978    3.8179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  8  1  0      
  1 16  1  0      
  6  2  1  6      
  3  4  1  0      
 15  3  1  0      
  4 12  2  0      
 23  5  2  0      
  5 24  1  0      
  6  7  1  0      
  6  8  1  0      
  7  9  1  0      
  9 20  1  0      
  9 21  2  0      
 12 10  1  0      
 13 10  1  0      
 15 10  2  0      
 11 13  2  0      
 11 14  1  0      
 17 11  1  0      
 12 18  1  0      
 19 14  2  0      
 14 23  1  0      
 15 22  1  0      
 16 19  1  0      
 16 24  2  0      
 18 17  2  0      
 20 25  2  0      
 26 21  1  0      
 25 27  1  0      
 27 26  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
M  END
>  <Catalog Number> (1)
A8616

>  <Item Name> (1)
A-674563

>  <Formula> (1)
C22H22N4O

>  <MolWeight> (1)
358.44

>  <CAS Number> (1)
552325-73-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8616

$$$$

Untitled Document
  ChemDraw07031413192D
 24 27  0  0  0  0  0  0  0  0999 V2000
   -2.4325   -1.6454    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1352    0.0399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8108   -1.6454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1082    0.6016    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0255    2.2072    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1082    1.7252    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4865   -1.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1352   -1.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1622   -0.5219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4595   -0.5219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4865    0.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1622   -1.6454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4865   -1.6454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4595    0.6016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1352    1.1634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8108   -2.2072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8108   -1.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4595    1.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5007    1.2983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4595   -2.2072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4595   -1.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4325    1.1634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4329    1.9434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7838   -1.6454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 24  1  0      
  2 10  1  0      
  2 11  1  0      
  2 14  1  0      
  3  7  1  0      
 14  4  2  0      
  4 22  1  0      
 18  5  1  0      
  5 23  1  0      
  6 18  1  0      
 22  6  2  0      
  8  7  1  0      
  7  9  1  0      
  7 12  1  0      
 10  8  1  0      
  9 11  1  0      
 12 13  1  0      
 13 16  1  0      
 13 17  2  0      
 14 15  1  0      
 18 15  2  0      
 19 15  1  0      
 16 20  2  0      
 21 17  1  0      
 23 19  2  0      
 20 24  1  0      
 24 21  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
M  END
>  <Catalog Number> (1)
A8617

>  <Item Name> (1)
CCT128930

>  <Formula> (1)
C18H20ClN5

>  <MolWeight> (1)
341.84

>  <CAS Number> (1)
885499-61-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8617

$$$$

Untitled Document
  ChemDraw03042010582D
 30 33  0  0  0  0  0  0  0  0999 V2000
    0.6955    1.2457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7050   -1.2457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7335   -2.0542    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2533    2.5242    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956    2.4913    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2628   -2.5242    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1338    0.4372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4241    0.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1243    1.2621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5532    1.2786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7050    0.4208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8340    1.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8530    0.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2628    1.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4335   -0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5627    0.4537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4051    1.6663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0047    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0047   -0.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7240   -1.2292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820    1.2950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4241   -0.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1338   -1.2621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8530   -0.8578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1243   -2.0871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0237   -2.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5627   -1.2786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8340   -2.5077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5532   -2.1035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9820   -2.1200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 11  1  1  0      
  1 17  1  0      
  2 19  1  0      
  2 22  1  0      
  3 20  1  0      
  3 26  1  0      
 14  4  1  6      
  5 17  2  0      
  6 29  1  0      
  6 30  1  0      
  8  7  1  0      
  9  7  1  0      
 13  7  2  0      
  8 11  1  0      
 15  8  2  0      
  9 12  2  0      
 17  9  1  0      
 12 10  1  0      
 10 14  1  0      
 10 16  2  0      
 11 18  2  0      
 16 13  1  0      
 14 21  1  0      
 20 15  1  0      
 19 18  1  0      
 19 20  2  0      
 22 23  1  0      
 23 24  2  0      
 23 25  1  0      
 24 27  1  0      
 28 25  2  0      
 27 29  2  0      
 29 28  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
M  END
>  <Catalog Number> (1)
A8618

>  <Item Name> (1)
Palomid 529

>  <Formula> (1)
C24H22O6

>  <MolWeight> (1)
406.43

>  <CAS Number> (1)
914913-88-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8618

$$$$

Untitled Document
  ChemDraw02192014512D
 29 33  0  0  0  0  0  0  0  0999 V2000
   -1.6614    0.7925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8137    0.8120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4069   -1.3411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4294    1.5168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6444    2.3098    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4068    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4182    0.0877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8249   -0.6170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -0.6299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4181   -1.3347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3956    1.5233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8362    0.7991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6906    2.2993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6388    0.8185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8137   -2.0588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0269    2.7896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6389   -2.0654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0569   -1.3541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0457   -2.7831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8819   -1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8707   -2.7896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2888   -2.0784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0513    0.1040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6388   -0.6104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0513   -1.3249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8763   -1.3249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2888   -0.6104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8763    0.1040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2888    0.8185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 12  2  0      
  2  6  1  0      
  2 11  1  0      
  2 14  1  0      
  9  3  1  0      
  3 10  1  0      
  3 15  1  0      
  4 11  1  0      
 12  4  1  0      
  4 13  1  0      
  5 11  2  0      
 16  5  1  0      
  6  7  2  0      
  6  8  1  0      
  7  9  1  0      
  7 12  1  0      
 10  8  1  0      
 13 16  1  0      
 15 17  1  0      
 17 18  1  0      
 17 19  2  0      
 18 20  2  0      
 21 19  1  0      
 20 22  1  0      
 22 21  2  0      
 14 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 27  1  0      
 27 28  2  0      
 28 23  1  0      
 28 29  1  0      
M  END
>  <Catalog Number> (1)
A8619

>  <Item Name> (1)
TIC10

>  <Formula> (1)
C24H26N4O

>  <MolWeight> (1)
386.49

>  <CAS Number> (1)
41276-02-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8619

$$$$

Untitled Document
  ChemDraw02192014562D
 35 37  0  0  1  0  0  0  0  0999 V2000
    0.7803   -1.0451    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.5752   -0.8240    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7812   -0.0251    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0145   -1.2662    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2222   -4.1052    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9871    0.7739    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6034    1.1306    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3975    0.1106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3983   -0.9095    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6041    2.1506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0152    2.7285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3991    2.3717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3982    1.3517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3973    0.3317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2212    3.5274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6050    3.1707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2204    2.5074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9879    1.7939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9864   -0.2462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6323    4.1052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3998    3.3918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3686    3.0852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7828    2.0150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6034   -0.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1625    3.8841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9888    2.8139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6043   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0154   -2.2862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3991   -1.9295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2213   -3.0852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6051   -2.7284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0161   -3.3063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4000   -2.9495    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.9888   -2.3716    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6059   -3.7483    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
  1 19  1  0      
  2 19  1  0      
  3 19  1  0      
  4 24  2  0      
  5 32  1  0      
  6 13  2  0      
  7 13  1  0      
 14  7  1  6      
  8 14  1  0      
  8 24  1  0      
  9 24  1  0      
  9 27  1  0      
 10 11  1  0      
 10 12  1  0      
 10 13  1  0      
 11 15  2  0      
 11 17  1  0      
 12 16  2  0      
 12 18  1  0      
 14 19  1  0      
 15 20  1  0      
 16 21  1  0      
 22 17  2  0      
 23 18  2  0      
 20 25  2  0      
 21 26  2  0      
 25 22  1  0      
 26 23  1  0      
 27 28  2  0      
 27 29  1  0      
 28 30  1  0      
 31 29  2  0      
 30 32  2  0      
 32 31  1  0      
 31 33  1  0      
 33 34  2  0      
 33 35  1  0      
M  CHG  2  33   1  35  -1
M  END
>  <Catalog Number> (1)
A8624

>  <Item Name> (1)
CGK733

>  <Formula> (1)
C23H18Cl3FN4O3S

>  <MolWeight> (1)
555.84

>  <CAS Number> (1)
905973-89-9

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8624

$$$$

Untitled Document
  ChemDraw03042011012D
 26 29  0  0  0  0  0  0  0  0999 V2000
   -1.0474   -1.6008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0474   -2.4258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3329   -2.8383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3816   -2.4258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3816   -1.6008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3329   -1.1883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0961   -2.8383    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8105   -2.4258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8105   -1.6008    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0961   -1.1883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7618   -1.1883    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4763   -1.6008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4763   -2.4258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7618   -2.8383    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0961   -0.3633    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6794    0.2200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3049    0.9551    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4900    0.8260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3610    0.0112    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4763    0.0065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0933    1.4094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3192    2.1239    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0933    2.8383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9183    2.8383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3308    2.1239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9183    1.4094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  4  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
 10  5  1  0      
  1 11  1  0      
 11 12  1  0      
 13 14  1  0      
 14  2  1  0      
 10 15  1  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19 15  1  0      
 16 20  1  0      
 18 21  1  0      
 21 22  2  0      
 22 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 21  1  0      
M  END
>  <Catalog Number> (1)
A8625

>  <Item Name> (1)
CP-466722

>  <Formula> (1)
C17H15N7O2

>  <MolWeight> (1)
349.35

>  <CAS Number> (1)
1080622-86-1

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8625

$$$$

Untitled Document
  ChemDraw02192015022D
 36 41  0  0  0  0  0  0  0  0999 V2000
    3.2967   -1.7893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2989   -0.3603    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0603   -1.0727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8191   -3.2142    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8239    1.0756    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6466   -1.7865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8216   -1.7851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0579   -2.5016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4150    1.7881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6489   -0.3576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8262    1.0728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4078   -2.4990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8830   -2.5031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4102   -1.0699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4148   -1.0685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8852   -1.0741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626    0.3562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8239   -0.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6441   -3.2155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6513    1.0715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.3590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4173   -2.4976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8286   -1.7824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8261   -0.3534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6512   -0.3519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    0.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4124    0.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6488    1.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    0.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0602    1.7922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2989    1.0798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8852    1.7936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8288    2.5018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2995    1.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3819    2.0016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2426    3.2155    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1 13  1  0      
 16  1  1  0      
  2 16  2  0      
  6  3  1  0      
  3 10  1  0      
  3 16  1  0      
  4 12  2  0      
 19  4  1  0      
 27  5  2  0      
 28  5  1  0      
  7  6  2  0      
  6  8  1  0      
  7 12  1  0      
 14  7  1  0      
 13  8  1  0      
  8 19  2  0      
  9 11  1  0      
 10 17  1  0      
 10 18  2  0      
 20 11  1  0      
 11 21  2  0      
 22 12  1  0      
 15 14  2  0      
 23 15  1  0      
 15 24  1  0      
 17 20  2  0      
 21 18  1  0      
 22 23  2  0      
 24 25  2  0      
 27 24  1  0      
 25 26  1  0      
 26 28  1  0      
 26 29  2  0      
 30 28  2  0      
 29 31  1  0      
 32 30  1  0      
 31 32  2  0      
  9 33  1  0      
  9 34  1  0      
  9 35  1  0      
 33 36  3  0      
M  END
>  <Catalog Number> (1)
A8626

>  <Item Name> (1)
ETP-46464

>  <Formula> (1)
C30H22N4O2

>  <MolWeight> (1)
470.52

>  <CAS Number> (1)
1345675-02-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8626

$$$$

Untitled Document
  ChemDraw11151813372D
 32 31  0  0  0  0  0  0  0  0999 V2000
    3.2044   -2.6237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.0462    2.4948    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7932    0.2880    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2676    0.2334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4282    1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8248    1.7531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3966    1.0115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6496    1.7713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8248    1.7167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8710    2.5129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6180    3.1999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6180    0.2699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2676    3.2364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0146   -0.4536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0462    0.9751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8394   -0.4718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5864   -1.1588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8710    0.9568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2360   -1.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9830   -1.8821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8078   -1.9004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8211    2.9864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8728   -0.0658    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2852   -0.7803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1583   -0.4782    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4603    0.6487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5873    0.3467    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8728   -2.5219    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2852   -3.2364    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1583   -2.9343    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4603   -1.8074    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5873   -2.1094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1 21  1  0      
  2  8  1  0      
  2 10  1  0      
  2 11  1  0      
  3  7  1  0      
  3 12  1  0      
 16  4  1  0      
 18  4  2  0      
  5  6  1  0      
  5  7  1  0      
  6  8  1  0      
  7  9  1  1      
 10 13  1  0      
 12 14  1  0      
 15 12  2  0      
 14 16  1  0      
 14 17  2  0      
 18 15  1  0      
 19 16  2  0      
 17 20  1  0      
 21 19  1  0      
 20 21  2  0      
 11 22  1  0      
 23 24  1  0      
 23 25  1  0      
 23 26  1  0      
 23 27  2  0      
 28 29  1  0      
 28 30  1  0      
 28 31  1  0      
 28 32  2  0      
V    1 0
V    2 11
V    3 12
V    4 13
V    5 14
V    6 15
V    7 16
V    8 17
V    9 18
V   10 19
V   11 20
V   12 21
V   13 23
V   14 24
V   15 25
V   16 26
V   17 27
V   18 28
V   19 29
V   20 30
V   21 31
V   23 1
V   24 6
V   25 7
V   26 8
V   27 9
V   28 2
V   29 3
V   30 4
V   31 5
V   32 10
M  END
>  <Catalog Number> (1)
A8628

>  <Item Name> (1)
Chloroquine diphosphate

>  <Formula> (1)
C18H26ClN3.2H3PO4

>  <MolWeight> (1)
515.86

>  <CAS Number> (1)
50-63-5

>  <Target> (1)
Ubiquitination/Proteasome

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8628

$$$$

Untitled Document
  ChemDraw06161514053D
 24 23  0  0  0  0  0  0  0  0999 V2000
    2.6365    1.9638    4.7065 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0408    1.4137    3.5298 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0378    1.9702    4.1389 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4451    0.8636    2.3532 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4421    1.4201    2.9623 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8494    0.3135    1.1766 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8464    0.8700    1.7857 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2537   -0.2366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2507    0.3199    0.6090 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3420   -0.7866   -1.1766 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3450   -0.2302   -0.5676 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9377   -1.3367   -2.3532 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9407   -0.7802   -1.7442 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5334   -1.8868   -3.5298 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5364   -1.3303   -2.9208 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1291   -2.4369   -4.7065 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1321   -1.8804   -4.0974 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7338    1.0850    3.8336 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3899    0.7674    3.1543 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8554   -0.7994   -0.0415 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8403   -2.2155   -3.2261 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1843   -2.5331   -3.9054 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4360    2.5331    4.1804 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7338   -1.3175   -4.0559 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0      
  3  1  1  0      
  4  5  1  0      
  5  2  1  0      
  6  7  1  0      
  7  4  1  0      
  8  9  1  0      
  9  6  1  0      
 10 11  1  0      
 11  8  1  0      
 12 13  1  0      
 13 10  1  0      
 14 15  1  0      
 15 12  1  0      
 16 17  1  0      
 17 14  1  0      
  2 18  1  0      
  2 19  1  0      
  8 20  1  0      
 14 21  1  0      
 14 22  1  0      
  3 23  2  0      
 17 24  2  0      
M  END
>  <Catalog Number> (1)
A8710

>  <Item Name> (1)
ETC-1002

>  <Formula> (1)
C19H36O5

>  <MolWeight> (1)
344.49

>  <CAS Number> (1)


>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8710

$$$$

Untitled Document
  ChemDraw02031515482D
 30 33  0  0  0  0  0  0  0  0999 V2000
   -3.2151    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2151   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.5006    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0881   -0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2151    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9131    1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  6  7  1  1      
  5  8  1  0      
  8  9  1  0      
  9 10  2  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13  8  2  0      
 10 14  1  0      
 14 15  1  0      
 15 16  1  0      
 16 17  1  0      
 17 11  1  0      
 14 18  1  0      
 18 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 23  1  0      
 23 24  2  0      
 24 19  1  0      
 12 25  2  0      
 23 26  1  0      
 15 27  1  1      
 27 28  1  0      
 27 29  1  0      
 27 30  1  0      
M  STY  1   1 SUP
M  SLB  1   1   1
M  SAL   1  4  27  28  29  30
M  SBL   1  1  30
M  SMT   1 CF3
M  SBV   1  30   -0.7145    0.4125
M  END
>  <Catalog Number> (1)
A8883

>  <Item Name> (1)
SAR405

>  <Formula> (1)
C19H21ClF3N5O2

>  <MolWeight> (1)
443.85

>  <CAS Number> (1)
1523406-39-4

>  <Target> (1)
Ubiquitination/Proteasome

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8883

$$$$

Untitled Document
  ChemDraw09131411182D
 35 40  0  0  0  0  0  0  0  0999 V2000
    2.1771    0.5508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5085    0.5007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1308    1.0547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4217    1.6588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0903    1.7089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4680    1.1549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0440    2.2127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3349    2.8168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0036    2.8669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3813    2.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6332    0.0593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5332   -0.6037    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9526   -0.9390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3284   -0.6940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1308   -0.0533    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0525   -1.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283   -2.0200    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9042   -1.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8042   -1.1120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3800   -2.1931    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2442   -1.9481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8092   -2.3091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3271   -1.8832    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0822   -1.2591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4129   -1.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9760   -2.0519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1544   -2.6983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8033   -2.8669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2739   -2.3893    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0955   -1.7430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4466   -1.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1139   -0.9390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2739    0.2569    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4678    0.0466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6767   -1.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0      
  6  1  2  0      
 11  1  1  0      
  2  3  2  0      
 15  2  1  0      
  3  4  1  0      
  4  5  1  0      
  4  7  2  0      
  5  6  1  0      
 10  5  2  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 11 12  1  0      
 11 33  2  0      
 12 13  1  0      
 12 32  1  0      
 13 14  1  0      
 13 16  2  0      
 14 15  1  0      
 19 14  2  0      
 15 34  1  0      
 16 17  1  0      
 16 35  1  0      
 17 18  2  0      
 18 19  1  0      
 18 20  1  0      
 20 21  1  0      
 22 21  2  0      
 21 25  1  0      
 22 23  1  0      
 24 23  1  0      
 23 26  1  0      
 25 24  2  0      
 26 27  1  0      
 31 26  1  0      
 27 28  1  0      
 29 28  1  0      
 29 30  1  0      
 30 31  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
M  END
>  <Catalog Number> (1)
A8890

>  <Item Name> (1)
HTH-01-015

>  <Formula> (1)
C26H28N8O

>  <MolWeight> (1)
468.55

>  <CAS Number> (1)
1613724-42-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=A8890

$$$$

Untitled Document
  ChemDraw02242010132D
 34 38  0  0  0  0  0  0  0  0999 V2000
   -0.7738    1.2516    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0620    1.5095    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1871   -2.5949    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6538    1.5449    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7523    0.3669    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7422   -1.9844    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5407    0.2148    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4140    1.2243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9921    0.6874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4629    2.0767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3058    0.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4801    0.4807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2920    0.9909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3541    1.9620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8654    1.6971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9150   -0.8805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5254   -1.4355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1141    0.9210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4663    2.3483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0904   -0.0743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4351   -2.2556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4812   -0.5766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1291   -1.1315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3332   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6767    2.5876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0683    2.9124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3441    0.4024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9680   -0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5391   -2.1980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2535   -1.7855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9516   -2.9124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1266   -2.9124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9680   -2.1980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2535   -0.9605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1 12  1  0      
 14  1  1  0      
  9  2  1  0      
  2 10  1  0      
 15  2  1  0      
  6  3  1  0      
 21  3  2  0      
  8  4  1  0      
 18  4  1  0      
  4 19  1  0      
  5  9  2  0      
 13  5  1  0      
 24  6  1  0      
 18  7  2  0      
  7 27  1  0      
 27  8  2  0      
  9 11  1  0      
 10 14  1  0      
 12 11  1  0      
 22 11  2  0      
 12 20  2  0      
 15 13  2  0      
 13 18  1  0      
 16 17  1  0      
 20 16  1  0      
 16 23  2  0      
 21 17  1  0      
 17 24  2  0      
 19 25  1  0      
 19 26  1  0      
 23 22  1  0      
 27 28  1  0      
  6 29  1  0      
 29 30  1  0      
 29 31  1  0      
 29 32  1  0      
 30 33  1  0      
 30 34  2  0      
V    1 0
V    2 2
V    3 3
V    4 4
V    5 5
V    6 6
V    7 7
V    8 8
V    9 11
V   10 12
V   11 13
V   12 14
V   13 15
V   14 16
V   15 17
V   16 18
V   17 19
V   18 20
V   19 21
V   20 22
V   21 23
V   22 24
V   23 27
V   24 29
V   25 30
V   26 31
V   27 32
V   28 33
M  END
>  <Catalog Number> (1)
B1047

>  <Item Name> (1)
GDC-0032

>  <Formula> (1)
C24H28N8O2

>  <MolWeight> (1)
460.53

>  <CAS Number> (1)
1282512-48-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1047

$$$$

Untitled Document
  ChemDraw02202011212D
 12 11  0  0  0  0  0  0  0  0999 V2000
   -1.8981   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0703   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7847   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0731   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3587    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3558   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3587    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0731    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3587   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3558    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0703   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8981    1.5723    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  4  1  1  6      
  7  5  1  0      
  8  4  1  0      
  8  5  2  0      
  9  4  1  0      
  9  6  2  0      
 10  5  1  0      
 10  6  1  0      
 11  2  1  0      
 11  3  1  0      
 11  6  1  0      
M  END
>  <Catalog Number> (1)
B1067

>  <Item Name> (1)
Imeglimin hydrochloride

>  <Formula> (1)
C6H14ClN5

>  <MolWeight> (1)
191.66

>  <CAS Number> (1)
775351-61-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1067

$$$$

Untitled Document
  ChemDraw07031416022D
 15 16  0  0  0  0  0  0  0  0999 V2000
    0.6996   -1.1274    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6025    0.3836    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4713   -0.8137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4707   -0.0508    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2887   -0.7873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1306    0.5383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5496    0.5383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1473   -0.1219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1941   -0.6723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8898   -0.0508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8898    1.1274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9102   -1.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5700   -0.0508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5700    1.1274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9102    0.5383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  5  1  0      
  9  1  1  0      
  2  8  2  0      
  3  9  2  0      
  4  6  1  0      
  8  4  1  0      
  9  4  1  0      
  5  8  1  0      
  5 12  1  0      
  6  7  1  0      
  7 10  1  0      
  7 11  2  0      
 10 13  2  0      
 14 11  1  0      
 13 15  1  0      
 15 14  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
M  END
>  <Catalog Number> (1)
B1249

>  <Item Name> (1)
TDZD-8

>  <Formula> (1)
C10H10N2O2S

>  <MolWeight> (1)
222.26

>  <CAS Number> (1)
327036-89-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1249

$$$$

Untitled Document
  ChemDraw02202015262D
 34 38  0  0  0  0  0  0  0  0999 V2000
    4.0267    2.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4137    2.8369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8551    1.4779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6290    2.5820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2936   -1.8969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2585   -1.2838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4566   -0.1782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0267   -0.7745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9894    1.6981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7680   -2.2103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8034   -0.3276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6350   -0.2522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1005   -1.7253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0035   -0.4991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0706    1.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4575    1.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3555   -0.9407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4354   -1.7253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5556    0.1140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2078   -2.0152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9146    0.5555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9159   -1.5921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7351    0.4693    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3625   -0.0576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7430    1.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1805   -0.9407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3006    0.8986    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2818   -2.8369    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2118    0.4560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3219    1.2132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4317    1.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0992    1.0640    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8529    1.3996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0131    0.2435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0      
  3  1  1  0      
  4  2  1  0      
  6  5  2  0      
  8  7  1  0      
 12  7  1  0      
 13  5  1  0      
 13 10  1  0      
 14  6  1  0      
 14 11  2  0      
 15  3  2  0      
 16  4  2  0      
 16 15  1  0      
 17 11  1  0      
 17 13  2  0      
 18 10  2  0      
 19 14  1  0      
 20 18  1  0      
 22  8  1  0      
 22 20  1  0      
 23 15  1  0      
 23 21  2  0      
 24 19  1  0      
 24 21  1  0      
 25  9  1  0      
 25 16  1  0      
 25 21  1  0      
 26 12  1  0      
 26 17  1  0      
 26 18  1  0      
 27 19  2  0      
 28 20  2  0      
 12 29  1  1      
  9 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 33  1  0      
 32 34  1  0      
M  END
>  <Catalog Number> (1)
B1295

>  <Item Name> (1)
BIX 02565

>  <Formula> (1)
C26H30N6O2

>  <MolWeight> (1)
458.56

>  <CAS Number> (1)
1311367-27-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1295

$$$$

Untitled Document
  ChemDraw07031416562D
 27 26  0  0  0  0  0  0  0  0999 V2000
    2.9256    2.4330    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    3.5458    2.0749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5675    1.8127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2837    3.0532    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.3054    2.7911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4066    2.4330    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.7296   -0.6682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3716   -0.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4458   -0.6682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6554   -0.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8039   -1.2885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2973    0.5723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5201   -1.2885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4189    0.5723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8782   -1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7863    2.0749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7770    1.1925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5944   -1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0268    2.7911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4066    3.1492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0268    2.0749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4932    1.1925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9525   -2.5289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1661    2.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8513    1.8127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6687   -2.5289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0268   -3.1492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  1  3  1  1      
  1  4  1  1      
  1  5  2  0      
  2 24  1  0      
  3 25  1  0      
  6 16  1  0      
  6 19  1  0      
  6 20  1  0      
  6 21  1  0      
  7  8  1  0      
  7  9  1  0      
  8 10  1  0      
  9 11  1  0      
 10 12  1  0      
 11 13  1  0      
 12 14  1  0      
 13 15  1  0      
 14 17  1  0      
 15 18  1  0      
 16 24  1  0      
 17 22  1  0      
 18 23  1  0      
 22 25  1  0      
 23 26  1  0      
 26 27  1  0      
M  CHG  2   4  -1   6   1
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
M  END
>  <Catalog Number> (1)
B1371

>  <Item Name> (1)
Miltefosine

>  <Formula> (1)
C21H46NO4P

>  <MolWeight> (1)
407.57

>  <CAS Number> (1)
58066-85-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1371

$$$$

Untitled Document
  ChemDraw03192010352D
  0  0  0     0  0              0 V3000
M  V30 BEGIN CTAB
M  V30 COUNTS 34 36 0 0 0
M  V30 BEGIN ATOM
M  V30 1 H -1.908424 -1.196250 0.000000 0
M  V30 2 Cl -1.083424 -1.196250 0.000000 0
M  V30 3 H -1.908424 -2.021250 0.000000 0
M  V30 4 Cl -1.083424 -2.021250 0.000000 0
M  V30 5 C 2.878854 0.066902 0.000000 0
M  V30 6 C 3.663476 -0.188037 0.000000 0
M  V30 7 C 3.918415 -0.972659 0.000000 0
M  V30 8 C 4.725387 -1.144186 0.000000 0
M  V30 9 C 4.980326 -1.928807 0.000000 0
M  V30 10 N 4.428293 -2.541902 0.000000 0
M  V30 11 C 3.621321 -2.370375 0.000000 0
M  V30 12 C 3.366382 -1.585753 0.000000 0
M  V30 13 C 4.148399 0.479402 0.000000 0
M  V30 14 N 3.663476 1.146841 0.000000 0
M  V30 15 N 2.878854 0.891902 0.000000 0
M  V30 16 C 2.164384 1.304402 0.000000 0
M  V30 17 C 1.449913 0.891902 0.000000 0
M  V30 18 C 0.735441 1.304402 0.000000 0
M  V30 19 C 0.020971 0.891902 0.000000 0
M  V30 20 C -0.693500 1.304402 0.000000 0
M  V30 21 C -0.693500 2.129402 0.000000 0
M  V30 22 O -1.407971 2.541902 0.000000 0
M  V30 23 C -2.122442 2.129402 0.000000 0
M  V30 24 C -2.836913 2.541902 0.000000 0
M  V30 25 N -3.551384 2.129402 0.000000 0
M  V30 26 C -3.551384 1.304402 0.000000 0
M  V30 27 C -4.265855 0.891902 0.000000 0
M  V30 28 C -4.980326 1.304402 0.000000 0
M  V30 29 C -4.980326 2.129402 0.000000 0
M  V30 30 C -4.265855 2.541902 0.000000 0
M  V30 31 C 0.020971 2.541902 0.000000 0
M  V30 32 C 0.735441 2.129402 0.000000 0
M  V30 33 C 1.449913 0.066902 0.000000 0
M  V30 34 N 2.164384 -0.345598 0.000000 0
M  V30 END ATOM
M  V30 BEGIN BOND
M  V30 1 1 1 2
M  V30 2 1 3 4
M  V30 3 2 5 6
M  V30 4 1 6 7
M  V30 5 1 7 8
M  V30 6 2 8 9
M  V30 7 1 9 10
M  V30 8 2 10 11
M  V30 9 1 11 12
M  V30 10 2 7 12
M  V30 11 1 6 13
M  V30 12 2 13 14
M  V30 13 1 14 15
M  V30 14 1 5 15
M  V30 15 1 15 16
M  V30 16 2 16 17
M  V30 17 1 17 18
M  V30 18 1 18 19
M  V30 19 2 19 20
M  V30 20 1 20 21
M  V30 21 1 21 22
M  V30 22 1 22 23
M  V30 23 1 23 24
M  V30 24 1 24 25
M  V30 25 1 25 26
M  V30 26 1 26 27
M  V30 27 1 27 28
M  V30 28 1 28 29
M  V30 29 1 29 30
M  V30 30 1 25 30
M  V30 31 2 21 31
M  V30 32 1 31 32
M  V30 33 2 18 32
M  V30 34 1 17 33
M  V30 35 2 33 34
M  V30 36 1 5 34
M  V30 END BOND
M  V30 END CTAB
M  END
>  <Catalog Number> (1)
B1372

>  <Item Name> (1)
Dorsomorphin 2HCl

>  <Formula> (1)
C24H25N5O.2HCl

>  <MolWeight> (1)
472.41

>  <CAS Number> (1)
1219168-18-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1372

$$$$

Untitled Document
  ChemDraw03192010332D
  0  0  0     0  0              0 V3000
M  V30 BEGIN CTAB
M  V30 COUNTS 16 15 0 0 0
M  V30 BEGIN ATOM
M  V30 1 N 3.215119 -0.092813 0.000000 0
M  V30 2 C 2.500648 0.319688 0.000000 0
M  V30 3 N 1.786178 -0.092813 0.000000 0
M  V30 4 C 1.071707 0.319688 0.000000 0
M  V30 5 N 0.357235 -0.092813 0.000000 0
M  V30 6 C -0.357235 0.319688 0.000000 0
M  V30 7 C -1.071706 -0.092813 0.000000 0
M  V30 8 C -1.786177 0.319688 0.000000 0
M  V30 9 C -1.786177 1.144688 0.000000 0
M  V30 10 C -2.500648 1.557187 0.000000 0
M  V30 11 C -3.215119 1.144688 0.000000 0
M  V30 12 C -3.215119 0.319688 0.000000 0
M  V30 13 C -2.500648 -0.092813 0.000000 0
M  V30 14 N 1.071707 1.144688 0.000000 0
M  V30 15 N 2.500648 1.144688 0.000000 0
M  V30 16 Cl 0.245119 -1.557187 0.000000 0
M  V30 END ATOM
M  V30 BEGIN BOND
M  V30 1 1 1 2
M  V30 2 1 2 3
M  V30 3 1 3 4
M  V30 4 1 4 5
M  V30 5 1 5 6
M  V30 6 1 6 7
M  V30 7 1 7 8
M  V30 8 1 8 9
M  V30 9 2 9 10
M  V30 10 1 10 11
M  V30 11 2 11 12
M  V30 12 1 12 13
M  V30 13 2 8 13
M  V30 14 2 4 14
M  V30 15 2 2 15
M  V30 END BOND
M  V30 END CTAB
M  END
>  <Catalog Number> (1)
B1373

>  <Item Name> (1)
Phenformin HCl

>  <Formula> (1)
C10H16ClN5

>  <MolWeight> (1)
241.72

>  <CAS Number> (1)
834-28-6

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1373

$$$$

Untitled Document
  ChemDraw07031420012D
 35 38  0  0  0  0  0  0  0  0999 V2000
    1.5869   -0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.9162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1158   -0.9162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9093    1.3743    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5869   -1.8324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6448   -1.8324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5290   -1.8324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3224   -1.3743    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5290   -0.9162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1158    0.9162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8513   -2.2904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8513   -1.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3803   -1.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3803   -2.2904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0579   -1.8324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1737   -1.8324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7934   -1.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7934   -2.2904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2645   -1.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2645   -2.2904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.8324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7934   -1.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2645   -0.4581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5869   -0.9162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7934   -0.4581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3224   -0.4581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3803   -0.4581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3803    0.4581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1158   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9093   -0.4581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9093    0.4581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1737   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1158    1.8324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3803    1.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3803    2.2904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 26  1  0      
  2 19  1  0      
  2 23  1  0      
  3 24  1  0      
  3 27  1  0      
  4 34  2  0      
  5 11  1  0      
  5 12  1  0      
  5 15  1  0      
  6 13  1  0      
 14  6  1  0      
  6 16  1  0      
  7 21  1  0      
  7 22  1  0      
 22  8  1  0      
 24  8  2  0      
  9 22  2  0      
 25  9  1  0      
 10 28  1  0      
 10 34  1  0      
 11 14  1  0      
 13 12  1  0      
 15 17  1  0      
 15 18  2  0      
 17 19  2  0      
 20 18  1  0      
 19 21  1  0      
 21 20  2  0      
 24 26  1  0      
 26 25  2  0      
 27 29  1  0      
 27 30  2  0      
 29 28  2  0      
 28 31  1  0      
 32 30  1  0      
 31 32  2  0      
 33 34  1  0      
 33 35  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
M  END
>  <Catalog Number> (1)
B1374

>  <Item Name> (1)
WZ4003

>  <Formula> (1)
C25H29ClN6O3

>  <MolWeight> (1)
496.99

>  <CAS Number> (1)
1214265-58-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1374

$$$$

Untitled Document
  ChemDraw01271515242D
 33 36  0  0  0  0  0  0  0  0999 V2000
    3.8198   -2.9641    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6498   -3.7714    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6270   -3.1341    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2461    0.1224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3340   -1.5000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7678   -2.7284    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7324    0.7890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1055    3.2878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8316   -1.7743    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9897   -2.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0124   -2.7941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7739   -1.9003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3756   -1.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4616   -3.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7560   -2.0100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3978   -2.4541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6542   -3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9486   -1.8400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5904   -2.2843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4734   -1.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1850    1.0162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7298   -0.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5165    0.5325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5217    1.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0396   -2.8984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5150   -0.2925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1901    2.4671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1003    1.8368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9380    0.6791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0242   -1.9443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7687    2.3204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6064    1.1627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7739    3.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  1  3  2  0      
  1 10  1  0      
  1 11  1  0      
  4  7  1  0      
 22  4  1  0      
 19  5  2  0      
  5 20  1  0      
  6 25  2  0      
 30  6  1  0      
  7 23  2  0      
  8 27  1  0      
  8 33  1  0      
  9 30  1  0      
 10 12  1  0      
 10 13  1  0      
 11 14  1  0      
 11 15  2  0      
 14 17  2  0      
 18 15  1  0      
 17 16  1  0      
 16 18  2  0      
 16 19  1  0      
 19 25  1  0      
 20 22  1  0      
 20 30  2  0      
 21 23  1  0      
 21 28  1  0      
 21 29  2  0      
 22 26  2  0      
 23 26  1  0      
 24 27  1  0      
 31 24  1  0      
 24 32  2  0      
 28 31  2  0      
 32 29  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
M  END
>  <Catalog Number> (1)
B1383

>  <Item Name> (1)
VE-822

>  <Formula> (1)
C24H25N5O3S

>  <MolWeight> (1)
463.55

>  <CAS Number> (1)
1232416-25-9

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1383

$$$$

Untitled Document
  ChemDraw07041410002D
 25 28  0  0  0  0  0  0  0  0999 V2000
    2.7348   -1.7500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0895    1.5863    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4885   -1.4851    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8979    0.3326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0779    2.1017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7348    0.6307    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9148   -1.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6854   -2.0910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8654   -1.3526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3086   -2.2234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5380   -1.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6685   -0.7467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2748    0.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0779    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0948   -0.2733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0454   -0.6143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5280    1.2678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1515   -0.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5280    1.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4524    1.5863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0797    0.9493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0797    2.2234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6314    1.2678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6314    1.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1831    0.9493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 10  1  0      
 11  1  1  0      
  2 20  2  0      
  3  7  1  0      
  3  8  1  0      
  3  9  1  0      
  4 13  1  0      
 15  4  1  0      
  5 19  1  0      
 20  5  1  0      
  6 25  3  0      
  7 11  1  0      
 10  8  1  0      
  9 12  1  0      
 12 15  2  0      
 16 12  1  0      
 13 14  2  0      
 18 13  1  0      
 14 17  1  0      
 14 20  1  0      
 18 16  2  0      
 19 17  1  0      
 21 17  2  0      
 19 22  2  0      
 23 21  1  0      
 22 24  1  0      
 24 23  2  0      
 23 25  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
M  END
>  <Catalog Number> (1)
B1536

>  <Item Name> (1)
AZD1080

>  <Formula> (1)
C19H18N4O2

>  <MolWeight> (1)
334.37

>  <CAS Number> (1)
612487-72-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1536

$$$$

Untitled Document
  ChemDraw07041410012D
 32 35  0  0  0  0  0  0  0  0999 V2000
    0.3970   -0.8186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3970    0.5565    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1909    0.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5878   -0.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1909   -0.8186    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7939   -0.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3817   -0.1310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5878    1.2440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1909    1.9316    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3817    1.2440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7787    1.9316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3817    2.6191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7787    3.3066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5726    3.3066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9695    2.6191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5726    1.9316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1909   -0.8186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9848   -0.8186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3817   -0.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9848    0.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1909    0.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1756   -0.1310    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1756    0.6629    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9695   -0.1310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1756   -0.9249    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4881   -1.3219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4881   -2.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1756   -2.5127    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8631   -2.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8631   -1.3219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1756   -3.3066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  1  6  2  0      
  3  2  2  0      
  2  7  1  0      
  4  3  1  0      
  5  4  2  0      
  4  9  1  0      
  6  5  1  0      
  5  8  1  0      
  7 18  1  0      
  7 22  2  0      
  9 10  2  0      
  9 11  1  0      
 11 12  1  0      
 12 13  1  0      
 17 12  2  0      
 13 14  2  0      
 14 15  1  0      
 16 15  2  0      
 16 17  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  2  0      
 20 23  1  0      
 21 22  1  0      
 23 24  2  0      
 23 25  2  0      
 23 26  1  0      
 26 27  1  0      
 26 31  1  0      
 27 28  1  0      
 28 29  1  0      
 29 30  1  0      
 29 32  1  0      
 30 31  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
M  END
>  <Catalog Number> (1)
B1537

>  <Item Name> (1)
AZD2858

>  <Formula> (1)
C21H23N7O3S

>  <MolWeight> (1)
453.52

>  <CAS Number> (1)
486424-20-8

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1537

$$$$

Untitled Document
  ChemDraw07041410012D
 22 25  0  0  0  0  0  0  0  0999 V2000
   -2.0524    1.6159    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.0956    1.3396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0524    0.2938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0910    1.7252    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1368   -0.3210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4781    0.4804    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1931    0.7535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3975    0.8791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4387    0.2019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4606    1.4796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    0.0764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0925   -0.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4950    1.2765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5409   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8860    0.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0122    1.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5810   -0.8791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4777   -1.3703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4376    0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5008    1.3703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5179   -1.4796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9663   -1.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 20  1  0      
  2 13  2  0      
  3  6  1  0      
  4 10  1  0      
 13  4  1  0      
  5  9  1  0      
 14  5  2  0      
  6 11  1  0      
  7  8  1  0      
  7  9  2  0      
  7 13  1  0      
 10  8  1  0      
 15  8  2  0      
 11  9  1  0      
 10 16  2  0      
 11 12  2  0      
 12 14  1  0      
 12 17  1  0      
 18 14  1  0      
 19 15  1  0      
 16 20  1  0      
 17 21  2  0      
 22 18  2  0      
 20 19  2  0      
 21 22  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
M  END
>  <Catalog Number> (1)
B1538

>  <Item Name> (1)
GSK-3 Inhibitor IX (BIO)

>  <Formula> (1)
C16H10BrN3O2

>  <MolWeight> (1)
356.17

>  <CAS Number> (1)
667463-62-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1538

$$$$

Untitled Document
  ChemDraw07041410012D
 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.7920   -1.1127    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0383    0.8300    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3387   -2.0283    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8774   -0.3007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4148   -0.5754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5845    0.1076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5845    0.9240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2268   -0.4900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1315    0.0314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2916    1.3323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7067   -1.1505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2916   -0.3007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0066   -1.2824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8774    1.3323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9987    0.9240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9987    0.1076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2916    2.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8774    2.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5187   -1.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3746   -1.8964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5845    2.5570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9987   -1.7257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8546   -2.5570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6666   -2.4716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  1  0      
 13  1  1  0      
  2  9  2  0      
  3 13  2  0      
  4  6  1  0      
  4  9  1  0      
  5  8  1  0      
  9  5  1  0      
 13  5  1  0      
  6  7  1  0      
 12  6  2  0      
 10  7  1  0      
  7 14  2  0      
  8 11  1  0      
 10 15  1  0      
 17 10  2  0      
 11 19  1  0      
 11 20  2  0      
 16 12  1  0      
 18 14  1  0      
 15 16  2  0      
 21 17  1  0      
 18 21  2  0      
 19 22  2  0      
 23 20  1  0      
 22 24  1  0      
 24 23  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
M  END
>  <Catalog Number> (1)
B1539

>  <Item Name> (1)
Tideglusib

>  <Formula> (1)
C19H14N2O2S

>  <MolWeight> (1)
334.39

>  <CAS Number> (1)
865854-05-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1539

$$$$

Untitled Document
  ChemDraw02212016502D
 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0130   -1.8470    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3365   -0.3987    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4614   -1.9008    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2087   -2.5882    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6797    0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2398   -1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0645   -1.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0019   -0.3696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6976    0.9255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8118   -1.8649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4209    1.3224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923    1.3533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4389    2.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0103    2.1781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7335    2.5750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335   -2.6061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3049    2.6061    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4123   -1.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0132   -0.4183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3861    0.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2110    0.3188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6365   -0.3880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2372   -1.1099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4614   -0.3729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1 10  1  0      
  2  5  1  0      
  7  2  1  0      
  3  7  2  0      
 16  3  1  0      
 10  4  1  0      
  4 16  2  0      
  5  8  2  0      
  5  9  1  0      
  7  6  1  0      
  8  6  1  0      
 10  6  2  0      
  9 11  2  0      
  9 12  1  0      
 11 13  1  0      
 14 12  2  0      
 13 15  2  0      
 15 14  1  0      
 14 17  1  0      
  1 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  2  0      
 21 22  1  0      
 22 23  2  0      
 23 18  1  0      
 22 24  1  0      
V    1 0
V    2 2
V    3 3
V    4 4
V    5 6
V    6 7
V    7 8
V    8 9
V    9 10
V   10 11
V   11 12
V   12 13
V   13 14
V   14 15
V   15 16
V   16 17
M  END
>  <Catalog Number> (1)
B1540

>  <Item Name> (1)
TWS119

>  <Formula> (1)
C18H14N4O2

>  <MolWeight> (1)
318.33

>  <CAS Number> (1)
601514-19-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1540

$$$$

Untitled Document
  ChemDraw03042011462D
 30 34  0  0  0  0  0  0  0  0999 V2000
   -3.7165    1.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9300    0.8981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3466    0.3147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5497    0.5282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3362    1.3251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9196    1.9085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8578    0.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2167    0.5981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5124    1.3683    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7061    2.7054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2894    3.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4198    0.3846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0073   -0.3299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7997   -0.1584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8859    0.6621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1322    0.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5533    1.1470    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4671    1.9675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7134    2.3031    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0460    1.8181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6685    2.2306    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3830   -0.7417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1695   -1.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7529   -2.1220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5497   -1.9085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7633   -1.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1799   -0.5282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1331   -2.4918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9300   -2.2783    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9196   -3.2887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  2  0      
  4  7  2  0      
  7  8  1  0      
  8  9  1  0      
  9  5  2  0      
  6 10  1  0      
 10 11  1  0      
  8 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  1  0      
 16 12  1  0      
 15 17  1  0      
 17 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 16  2  0      
 20 21  1  0      
 22 14  1  1      
 22 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 22  1  0      
 25 28  1  1      
 28 29  1  0      
 28 30  2  0      
M  END
>  <Catalog Number> (1)
B1637

>  <Item Name> (1)
OSI-027

>  <Formula> (1)
C21H22N6O3

>  <MolWeight> (1)
406.45

>  <CAS Number> (1)
936890-98-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1637

$$$$

Untitled Document
  ChemDraw06011713592D
 69 72  0  0  0  0  0  0  0  0999 V2000
   -4.9350    4.5485    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9250    5.3734    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407    4.3253    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7292    4.7716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1581    3.7542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3465    4.1022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3564    3.2772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6470    2.8561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9276    3.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9176    4.0849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6271    4.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0759    2.8734    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7853    3.2945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2182    2.8388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2282    2.0139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4339    1.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0301    1.0713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4512    0.3619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9476    1.6101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0474   -0.3575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2761    0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6800    1.0913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5049    1.1013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9260    0.3918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5222   -0.3276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6972   -0.3375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2934   -1.0570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7145   -1.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4685   -1.0669    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3107   -2.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5395   -1.7564    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7318   -3.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5568   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1356   -2.4758    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3280   -3.9146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5031   -3.9246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0819   -3.2152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4858   -2.4958    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7430   -3.2252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1468   -3.9446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7257   -4.6540    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1295   -5.3734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3756   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9718   -3.9545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3929   -3.2451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2178   -3.2551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7941   -3.8455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5336   -3.4799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4144   -2.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2180    1.7703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8135    2.4909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0136    2.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4467    1.0409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0429    1.7603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2346    3.2004    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7969    1.0609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0256    0.3315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6755    0.3116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2717    1.0310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6928    1.7404    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9043   -0.4178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5004    0.3016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4524   -0.4827    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8562   -1.2021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6811   -1.2121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8850   -2.0115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7099   -2.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7292   -0.4278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0966    0.8718    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  1  3  1  0      
  1  4  1  0      
  1  5  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11  6  1  0      
  6  3  1  6      
  7 12  1  1      
 12 13  1  0      
  9 14  1  1      
 14 15  1  0      
 15 16  1  0      
 17 18  1  0      
 15 19  1  6      
 18 20  2  0      
 21 22  1  0      
 22 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 21  1  0      
 21 18  1  1      
 26 27  1  0      
 27 28  1  0      
 27 29  2  0      
 28 30  1  0      
 28 31  2  0      
 32 33  1  1      
 30 34  1  1      
 30 32  1  0      
 32 35  1  0      
 35 36  1  0      
 36 37  1  0      
 37 38  1  0      
 38 30  1  0      
 37 39  1  6      
 39 40  1  0      
 41 42  1  0      
 43 44  1  0      
 44 40  1  0      
 40 41  1  1      
 44 45  2  0      
 45 46  1  0      
 46 47  2  0      
 47 48  1  0      
 48 49  2  0      
 50 51  1  0      
 51 52  1  0      
 52 16  1  0      
 16 17  1  6      
 53 54  2  0      
 54 50  1  0      
 51 55  2  0      
 50 56  1  1      
 53 57  1  0      
 58 59  1  0      
 59 53  1  0      
 59 60  1  1      
 61 62  1  0      
 62 58  1  0      
 58 63  1  6      
 63 64  1  0      
 61 65  1  0      
 65 66  1  0      
 49 66  1  0      
 66 67  1  6      
 61 68  1  6      
 62 69  2  0      
M  END
>  <Catalog Number> (1)
B1639

>  <Item Name> (1)
Ridaforolimus (Deforolimus, MK-8669)

>  <Formula> (1)
C53H84NO14P

>  <MolWeight> (1)
990.21

>  <CAS Number> (1)
572924-54-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1639

$$$$

Untitled Document
  ChemDraw07021413192D
 32 36  0  0  0  0  0  0  0  0999 V2000
    0.3381    2.7329    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3381    2.3425    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0143    2.3425    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.3668    0.7808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6906   -0.3904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6906   -2.7329    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3668   -1.1713    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0430    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6906   -1.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0143   -1.5617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3668   -1.5617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0143   -2.3425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0143    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3381   -1.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3381   -1.5617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3668    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0430   -1.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3668   -2.3425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3381   -2.7329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0430   -0.3904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3381   -2.3425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0143    0.7808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3381   -0.3904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0143   -1.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3381    1.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3381    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3381    0.7808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0143   -0.3904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3381    1.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6906   -1.5617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6906    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3668   -0.3904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 29  1  0      
  2 29  1  0      
  3 29  1  0      
  4 16  2  0      
  9  5  1  0      
  5 13  1  0      
 16  5  1  0      
  6 12  2  0      
 18  6  1  0      
 30  7  2  0      
  7 32  1  0      
  8 32  1  0      
 10  9  2  0      
 11  9  1  0      
 12 10  1  0      
 14 10  1  0      
 17 11  1  0      
 11 18  2  0      
 12 19  1  0      
 13 22  1  0      
 13 23  2  0      
 15 14  2  0      
 21 15  1  0      
 15 24  1  0      
 16 20  1  0      
 20 17  2  0      
 19 21  2  0      
 22 25  2  0      
 26 23  1  0      
 28 24  2  0      
 24 30  1  0      
 25 27  1  0      
 25 29  1  0      
 27 26  2  0      
 31 28  1  0      
 31 32  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
M  END
>  <Catalog Number> (1)
B1640

>  <Item Name> (1)
Torin 2

>  <Formula> (1)
C24H15F3N4O

>  <MolWeight> (1)
432.41

>  <CAS Number> (1)
1223001-51-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1640

$$$$

Untitled Document
  ChemDraw02222010082D
 37 43  0  0  0  0  0  0  0  0999 V2000
    1.1413   -1.4928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6178   -0.8194    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3557   -1.6692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0857   -0.4408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3536   -1.2477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3432   -0.4228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3764   -0.0193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1245   -0.1581    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0753   -1.2656    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3453   -2.4941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3695    0.6297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8053   -0.0373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8209    0.7876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5430    1.1865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2496    0.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2496   -0.0643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5430   -0.4632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1743    0.8114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4193    1.5991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8596    2.2052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0549    2.0235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8098    1.2358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0623   -2.9023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0623   -3.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3453   -4.1441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3716   -3.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3716   -2.9023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1046    2.9930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9094    3.1747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0341    1.0154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5189    0.3481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0341   -0.3192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4691    2.5686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2739    2.7502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5189    3.5380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9592    4.1441    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1544    3.9624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  1  5  1  0      
  2  8  1  0      
  3  5  2  0      
  9  3  1  0      
  7  4  1  0      
  4  9  2  0      
  6  5  1  0      
  6  7  2  0      
  8  6  1  0      
  3 10  1  0      
  8 11  1  0      
  4 12  1  0      
 12 13  2  0      
 13 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 12  1  0      
 11 18  1  0      
 18 19  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 11  1  0      
 10 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 27  1  0      
 27 10  1  0      
 20 28  1  0      
 28 29  1  0      
 15 30  1  0      
 30 31  1  0      
 31 32  2  0      
 32 16  1  0      
 29 33  2  0      
 33 34  1  0      
 34 35  2  0      
 35 36  1  0      
 36 37  2  0      
 37 29  1  0      
V    1 2
V    2 3
V    3 5
V    4 6
V    5 15
V    6 16
V    7 17
V    8 18
V    9 22
M  END
>  <Catalog Number> (1)
B1641

>  <Item Name> (1)
WAY-600

>  <Formula> (1)
C28H30N8O

>  <MolWeight> (1)
494.59

>  <CAS Number> (1)
1062159-35-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1641

$$$$

Untitled Document
  ChemDraw03182016162D
 38 44  0  0  0  0  0  0  0  0999 V2000
    1.4177   -0.0420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4384   -0.8667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7345   -1.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7553   -2.1218    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5074   -2.4609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7111   -3.2604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2131   -3.9181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3884   -3.9389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1421   -3.3070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0212   -2.4983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7711   -2.7509    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0099   -0.9027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.0779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6931    0.3524    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7354    0.3165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7562    1.1412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4808    1.5356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1847    1.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1639    0.2805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4393   -0.1139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2262    2.7548    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9300    2.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9093    1.4997    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6754    3.5436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6547    2.7188    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2292   -1.1018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6972   -0.4224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1956    0.2326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4308    1.0234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2332    1.2152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4683    2.0059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9010    2.6050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0986    2.4132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8635    1.6224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6754    2.8895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6441    3.7139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8504    3.9389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3911    3.2535    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
  4 10  1  0      
  9 11  1  0      
  6 11  1  0      
  3 12  1  0      
 12 13  2  0      
 13 14  1  0      
  1 14  2  0      
 13 15  1  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 15  2  0      
 21 22  2  0      
 22 23  1  0      
 23 18  1  0      
 24 25  1  0      
 25 22  1  0      
  2 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28  1  1  0      
 28 29  1  0      
 29 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 33  1  0      
 33 34  1  0      
 34 29  1  0      
 32 35  1  0      
 35 36  1  0      
 36 37  1  0      
 37 38  1  0      
 38 32  1  0      
M  END
>  <Catalog Number> (1)
B1642

>  <Item Name> (1)
WYE-125132 (WYE-132)

>  <Formula> (1)
C27H33N7O4

>  <MolWeight> (1)
519.61

>  <CAS Number> (1)
1144068-46-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1642

$$$$

Untitled Document
  ChemDraw07021415212D
 20 21  0  0  0  0  0  0  0  0999 V2000
    2.4224   -2.0978    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8261   -1.3986    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4224   -0.6993    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4037    1.3986    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6149    2.0978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4037   -0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2112   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2112   -1.3986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8075   -0.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6149    0.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4037   -1.3986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8075   -2.0978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6149   -0.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.0978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4224    0.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0186   -1.3986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4224   -0.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8261   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2112    1.3986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 17  1  0      
  2 17  1  0      
  3 17  1  0      
  4 20  1  0      
  5 20  2  0      
  6  7  1  0      
  6  8  1  0      
  7 10  1  0      
  7 12  2  0      
  8 11  1  0      
  8 14  2  0      
 10  9  2  0      
  9 13  1  0      
  9 17  1  0      
 11 16  2  0      
 11 20  1  0      
 15 12  1  0      
 13 15  2  0      
 18 14  1  0      
 16 19  1  0      
 19 18  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
M  END
>  <Catalog Number> (1)
B1760

>  <Item Name> (1)
Flufenamic acid

>  <Formula> (1)
C14H10F3NO2

>  <MolWeight> (1)
281.23

>  <CAS Number> (1)
530-78-9

>  <Target> (1)
Immunology/Inflammation

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1760

$$$$

Untitled Document
  ChemDraw02242010322D
 10  8  0  0  0  0  0  0  0  0999 V2000
    1.3376   -0.9258    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8193   -0.7210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4124    0.0032    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8306    0.7079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4013    1.4321    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6443    0.7274    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4013   -1.4321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6443   -0.7274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4124   -0.0032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8193    0.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  7  1  0      
  2  8  1  0      
  2  9  1  0      
  3  9  1  0      
  3 10  2  0      
  4  9  2  0      
  5 10  1  0      
  6 10  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
M  END
>  <Catalog Number> (1)
B1970

>  <Item Name> (1)
Metformin HCl

>  <Formula> (1)
C4H12ClN5

>  <MolWeight> (1)
165.62

>  <CAS Number> (1)
1115-70-4

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B1970

$$$$

Untitled Document
  ChemDraw02222015552D
 24 28  0  0  0  0  0  0  0  0999 V2000
   -0.7145   -0.7998    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2993   -0.0869    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2541   -2.2352    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1665   -2.3899    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0107   -1.2371    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5210    0.5801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8400    2.0533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5353   -0.8829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9505   -1.5959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0850   -0.2678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7569   -1.4213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8400   -0.6005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1648   -1.4150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5902   -1.0823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5070   -0.2615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1222    0.2882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2558   -1.5697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9538    1.0959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4115   -2.7226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9058    0.0304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5689    1.6456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3526    1.3877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5720    2.4706    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3576    2.7226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  1  8  1  0      
  1 13  1  0      
  2 15  2  0      
  3 13  2  0      
 19  3  1  0      
 17  4  1  0      
  4 19  2  0      
  5 17  1  0      
 20  6  2  0      
  6 22  1  0      
  7 22  1  0      
  7 24  2  0      
  8  9  1  0      
  8 10  1  0      
  9 11  1  0      
 12 10  1  0      
 11 12  1  0      
 14 13  1  0      
 15 14  1  0      
 14 17  2  0      
 15 16  1  0      
 18 16  2  0      
 16 20  1  0      
 21 18  1  0      
 21 22  2  0      
 23 21  1  0      
 24 23  1  0      
M  END
>  <Catalog Number> (1)
B2172

>  <Item Name> (1)
PP121

>  <Formula> (1)
C17H17N7

>  <MolWeight> (1)
319.37

>  <CAS Number> (1)
1092788-83-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2172

$$$$

Untitled Document
  ChemDraw02222015512D
 34 38  0  0  1  0  0  0  0  0999 V2000
   -4.2868    1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.9163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.5038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.9163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.1538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.9163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.1538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.1538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.1538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.9788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.9788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.1538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.9163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.5038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.9163    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.7337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.5587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.9712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.5587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.7337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8158   -2.1107    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1514   -2.8644    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9719   -2.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5239   -3.3913    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.1538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  7  8  2  0      
  8  9  1  0      
  9  5  1  0      
 10 11  1  0      
 11  8  1  6      
 10 12  1  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15 11  1  0      
 12 16  1  0      
 16 17  2  0      
 13 18  1  1      
 16 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 17  1  0      
 20 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 27  1  0      
 27 28  2  0      
 28 23  1  0      
 25 29  1  0      
 29 30  1  0      
 30 31  2  0      
 31 26  1  0      
 31 32  1  0      
 22 33  1  0      
 33 34  1  0      
M  END
>  <Catalog Number> (1)
B2174

>  <Item Name> (1)
GSK2334470

>  <Formula> (1)
C25H34N8O

>  <MolWeight> (1)
462.59

>  <CAS Number> (1)
1227911-45-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2174

$$$$

Untitled Document
  ChemDraw07031414332D
 24 27  0  0  0  0  0  0  0  0999 V2000
   -1.2646   -1.7003    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1680   -0.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4399   -1.2491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4399   -0.3532    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3841   -0.5635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6192    1.4129    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163   -0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8281   -0.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -0.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -1.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044    0.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8281   -1.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163   -1.7662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8281    0.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0074   -1.7662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4399    0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6192   -1.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044    1.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0074    0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6930   -0.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0074    1.7662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6192    0.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7373   -1.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 18  1  1  0      
  1 24  1  0      
  2 21  2  0      
  3 24  2  0      
  9  4  1  0      
 17  4  2  0      
  5 21  1  0      
 24  5  1  0      
 22  6  2  0      
  6 23  1  0      
  8  7  1  0      
  7  9  1  0      
  7 10  2  0      
  8 12  1  0      
 15  8  2  0      
 13  9  2  0      
 10 11  1  0      
 11 14  2  0      
 11 16  1  0      
 12 19  2  0      
 20 12  1  0      
 14 13  1  0      
 17 15  1  0      
 16 18  2  0      
 18 21  1  0      
 19 22  1  0      
 20 23  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
M  END
>  <Catalog Number> (1)
B2176

>  <Item Name> (1)
GSK1059615

>  <Formula> (1)
C18H11N3O2S

>  <MolWeight> (1)
333.36

>  <CAS Number> (1)
958852-01-2

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2176

$$$$

Untitled Document
  ChemDraw02272013282D
 45 50  0  0  0  0  0  0  0  0999 V2000
    4.1252   -3.9298    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1878    1.0717    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2376    3.9298    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4126   -1.7863    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1252   -2.5007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3628   -0.3573    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5377    1.0717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    2.5007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3001    1.7863    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4126   -3.2153    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    1.0717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3001    0.3573    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -2.5007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502   -1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3628   -1.7863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1252   -1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7127   -1.7863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502   -2.5007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7127   -3.2153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1878   -0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8877   -3.2153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4751   -2.5007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4751   -3.9298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9502    0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9502    1.7863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4751    3.2153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2376    2.5007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6501   -2.5007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6501   -3.9298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2376   -3.2153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7752    0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7752    1.7863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    3.9298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    3.2153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7127    1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4751    1.7863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4751    0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.5007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2376   -0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4751   -1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2376   -1.7863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -1.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -1.7863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 19  2  0      
  2 32  1  0      
 33  2  1  0      
  3 34  1  0      
 35  3  1  0      
  4 40  2  0      
  5 17  1  0      
  5 18  1  0      
  5 19  1  0      
  6 14  1  0      
  6 20  1  0      
  6 21  1  0      
  7 25  1  0      
  7 26  1  0      
  7 36  1  0      
  8 27  1  0      
  8 28  1  0      
  8 37  1  0      
  9 36  2  0      
 37  9  1  0      
 10 31  1  0      
 10 40  1  0      
 11 37  2  0      
 38 11  1  0      
 36 12  1  0      
 38 12  2  0      
 13 40  1  0      
 13 43  1  0      
 14 15  1  0      
 16 14  1  0      
 15 18  1  0      
 17 16  1  0      
 19 22  1  0      
 22 23  2  0      
 22 24  1  0      
 23 29  1  0      
 30 24  2  0      
 32 25  1  0      
 26 33  1  0      
 34 27  1  0      
 28 35  1  0      
 29 31  2  0      
 31 30  1  0      
 38 39  1  0      
 39 41  2  0      
 39 42  1  0      
 41 44  1  0      
 45 42  2  0      
 44 43  2  0      
 43 45  1  0      
M  END
>  <Catalog Number> (1)
B2179

>  <Item Name> (1)
PF-05212384 (PKI-587)

>  <Formula> (1)
C32H41N9O4

>  <MolWeight> (1)
615.73

>  <CAS Number> (1)
1197160-78-3

>  <Target> (1)
GPCR/G protein

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2179

$$$$

Untitled Document
  ChemDraw03042013502D
 21 23  0  0  0  0  0  0  0  0999 V2000
   -2.5862    2.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5862    1.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8717    0.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1572    1.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1572    2.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8717    2.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3006    2.4241    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4428    2.4241    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4428    0.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4428   -0.0509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3419   -0.3058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8268    0.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3419    1.0290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6518    0.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0643   -0.3529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8508   -1.1498    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5427   -1.5991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1838   -1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8881   -0.3097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5427   -2.4241    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3006    0.4048    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  1  7  1  0      
  5  8  1  0      
  4  9  1  0      
  9 10  2  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13  9  1  0      
 12 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 15  1  0      
 17 20  2  0      
 19 21  2  0      
M  END
>  <Catalog Number> (1)
B2180

>  <Item Name> (1)
AS-252424

>  <Formula> (1)
C14H8FNO4S

>  <MolWeight> (1)
305.28

>  <CAS Number> (1)
900515-16-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2180

$$$$

Untitled Document
  ChemDraw02222015442D
 20 22  0  0  0  0  0  0  0  0999 V2000
   -3.1940    2.8419    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6851   -0.0695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6384    0.7542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2773    1.2761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0837   -0.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1593    0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6057    0.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0487    0.9838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1447    2.0904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6877    1.5057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7837    2.6123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5551    2.3200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2938   -1.1663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0907   -1.3798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3864   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2103   -2.1068    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4238   -1.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7319   -0.8606    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.9371   -2.8419    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1940   -1.0143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1 12  1  0      
  3  2  1  0      
  5  2  1  0      
  3  4  1  0      
  3  6  2  0      
  4  8  1  0      
  4  9  2  0      
  7  5  2  0      
  6  7  1  0      
  8 10  2  0      
 11  9  1  0      
 10 12  1  0      
 12 11  2  0      
  5 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18 14  1  0      
 15 19  2  0      
 17 20  2  0      
M  END
>  <Catalog Number> (1)
B2182

>  <Item Name> (1)
CAY10505

>  <Formula> (1)
C14H8FNO3S

>  <MolWeight> (1)
289.28

>  <CAS Number> (1)
1218777-13-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2182

$$$$

Untitled Document
  ChemDraw02222016132D
 35 39  0  0  0  0  0  0  0  0999 V2000
   -1.1526    0.6085    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7683   -0.9197    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0585    3.2027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2100    2.3461    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6296    3.1868    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1185   -0.9014    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3563   -0.8739    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8732   -1.6021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6175   -3.0034    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3880   -3.7316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6333   -4.4322    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2009    3.1710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9290    1.9415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9107    3.5914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6388    2.3619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4998    1.9257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4907    1.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1822    0.6233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3395    3.6072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8890   -0.1732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0641   -0.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2936   -0.8922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5230   -1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5389   -0.1916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3303    4.4322    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3479   -1.6296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3638   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9638    0.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0482   -1.5929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3721   -2.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1971   -2.2935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0324   -3.0217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2129   -3.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7683    3.6231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0677    2.3778    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1 17  1  0      
 20  1  1  0      
  2 26  1  0      
 27  2  1  0      
  3 19  1  0      
  4 12  1  0      
  4 13  1  0      
  4 16  1  0      
 14  5  1  0      
  5 15  1  0      
  5 19  1  0      
  6 22  1  0      
  6 23  1  0      
  6 24  1  0      
 21  7  2  0      
 29  7  1  0      
  8 22  1  0      
 29  8  2  0      
 31  9  2  0      
 33  9  1  0      
 32 10  1  0      
 10 33  2  0      
 11 33  1  0      
 12 14  1  0      
 15 13  1  0      
 16 17  1  0      
 17 18  2  0      
 18 21  1  0      
 18 28  1  0      
 19 25  2  0      
 20 21  1  0      
 22 20  2  0      
 26 23  1  0      
 24 27  1  0      
 29 30  1  0      
 31 30  1  0      
 30 32  2  0      
  3 34  1  0      
  3 35  1  6      
M  END
>  <Catalog Number> (1)
B2184

>  <Item Name> (1)
GDC-0980 (RG7422)

>  <Formula> (1)
C23H30N8O3S

>  <MolWeight> (1)
498.61

>  <CAS Number> (1)
1032754-93-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2184

$$$$

Untitled Document
  ChemDraw07031414362D
 31 34  0  0  0  0  0  0  0  0999 V2000
   -1.5509   -2.9752    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8219   -2.8986    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9818   -2.3822    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3614    1.7982    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2046    2.1256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2611    2.9752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9274    1.4934    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0996   -0.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8933    0.7380    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7331    0.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2104    1.3410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4179    0.9486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1539    2.1905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2236    1.0362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0161    0.6438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8015   -0.8130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8166    0.0090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1349    1.1010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8709    2.3429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9971    1.7333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2801    1.8857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0725   -0.8896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2256   -1.5593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3614   -0.4815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3584   -0.2966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9547   -1.6359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4876    2.2781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2052   -2.1523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0874   -0.3732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3855   -1.0429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2528   -2.3055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 31  1  0      
  2 31  1  0      
  3 31  1  0      
  4 18  1  0      
 19  4  1  0      
  5 27  1  0      
  6 27  2  0      
  7 11  1  0      
  7 12  1  0      
  7 13  1  0      
  8 10  1  0      
  8 16  1  0      
 17  8  1  0      
  9 14  1  0      
  9 17  2  0      
 10 14  1  0      
 10 15  2  0      
 15 11  1  0      
 11 21  2  0      
 18 12  1  0      
 13 19  1  0      
 20 14  2  0      
 16 22  1  0      
 17 24  1  0      
 21 20  1  0      
 20 27  1  0      
 22 23  1  0      
 22 25  2  0      
 23 26  2  0      
 23 28  1  0      
 29 25  1  0      
 26 30  1  0      
 26 31  1  0      
 30 29  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
M  END
>  <Catalog Number> (1)
B2186

>  <Item Name> (1)
GSK2636771

>  <Formula> (1)
C22H22F3N3O3

>  <MolWeight> (1)
433.42

>  <CAS Number> (1)
1372540-25-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2186

$$$$

Untitled Document
  ChemDraw02222016112D
 37 42  0  0  0  0  0  0  0  0999 V2000
   -3.0054    0.6366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5765    0.6195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5617    0.1813    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8770   -0.6265    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3193    0.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1477    0.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8671    0.1985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3058   -0.6094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6380   -0.6401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2960    0.2156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5667    1.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4430   -0.8213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5964   -1.0304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8640   -0.1119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0252   -1.0132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8473    1.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6063   -1.8553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2761    1.8655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0351   -1.8382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3256   -2.2592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7347   -0.5922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8375    2.6733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1379    1.4273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2663    2.6904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5469    3.0943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6731    0.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9375    0.8315    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3929    1.4513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5838    1.2895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7694   -1.5790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2765   -2.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6030   -2.9982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4224   -3.0943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9153   -2.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5888   -1.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7347   -2.5288    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2177   -0.5698    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1 10  2  0      
  2  7  1  0      
 10  2  1  0      
  2 11  1  0      
  3  5  1  0      
  3  6  1  0      
  3  9  1  0      
  7  4  2  0      
  4 13  1  0      
  5 14  1  0      
  6  7  1  0      
  8 10  1  0      
  8 13  1  0      
 15  8  2  0      
 12  9  2  0      
 11 16  1  0      
 11 18  2  0      
 14 12  1  0      
 17 13  2  0      
 19 15  1  0      
 15 21  1  0      
 16 22  2  0      
 16 23  1  0      
 17 20  1  0      
 18 24  1  0      
 20 19  2  0      
 22 25  1  0      
 24 25  2  0      
 14 26  2  0      
 26 27  1  0      
 27 28  2  0      
 28 29  1  0      
 29  5  2  0      
 12 30  1  0      
 30 31  2  0      
 31 32  1  0      
 32 33  2  0      
 33 34  1  0      
 34 35  2  0      
 35 30  1  0      
 34 36  1  0      
 26 37  1  0      
M  END
>  <Catalog Number> (1)
B2188

>  <Item Name> (1)
PIK-294

>  <Formula> (1)
C28H23N7O2

>  <MolWeight> (1)
489.53

>  <CAS Number> (1)
900185-02-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2188

$$$$

Untitled Document
  ChemDraw02272013292D
 35 40  0  0  0  0  0  0  0  0999 V2000
   -1.1640    0.9386    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4021    2.1476    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4961    3.4670    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9239    3.5223    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7468    1.7644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0267    2.1671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7580    0.9395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3180    1.7448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0493    0.5173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3292    0.9199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1320    1.7630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8300    2.2028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5598    1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7981    3.0272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2578    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2259    3.0825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0606   -0.3077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3434   -0.7154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3434   -1.5404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0606   -1.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7778   -1.5404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7778   -0.7154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2750   -2.0936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0600   -2.8526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8854   -2.7686    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0999   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5898   -2.6738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2548   -3.4328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4299   -3.5223    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4929   -1.9517    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4950   -2.7767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2105   -3.1874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9239   -2.7767    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9239   -1.9517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2105   -1.5410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 11  2  0      
  2  8  1  0      
  2 11  1  0      
 14  3  2  0      
  3 16  1  0      
  4 16  1  0      
  5  6  2  0      
  5  7  1  0      
  6  8  1  0      
  9  7  2  0      
  8 10  2  0      
 10  9  1  0      
 11 12  1  0      
 13 12  2  0      
 12 14  1  0      
 15 13  1  0      
 15 16  2  0      
  9 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 17  1  0      
 19 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 20  1  0      
 23 26  2  0      
 26 27  1  0      
 27 28  2  0      
 28 29  1  0      
 29 24  2  0      
 21 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 33  1  0      
 33 34  1  0      
 34 35  1  0      
 35 30  1  0      
M  END
>  <Catalog Number> (1)
B2189

>  <Item Name> (1)
YM201636

>  <Formula> (1)
C25H21N7O3

>  <MolWeight> (1)
467.48

>  <CAS Number> (1)
371942-69-7

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2189

$$$$

Untitled Document
  ChemDraw02222016072D
 29 29  0  0  0  0  0  0  0  0999 V2000
    3.4039    1.4500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5828    1.4088    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7588    1.3674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6241    0.5876    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3840    0.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5629    0.5943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1881   -0.1374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6330   -0.1787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0079   -0.9104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8290   -0.9517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2038   -1.6834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0278   -1.7249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4039   -2.4591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9561   -3.1520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1321   -3.1106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7559   -2.3763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3309   -3.8838    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.5828    2.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2973    2.6461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2973    3.4711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5828    3.8838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8683    3.4711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8683    2.6461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1538    3.8836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4393    3.4711    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4393    2.6461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1538    2.2336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7976   -2.6479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.2692   -3.6869    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  2  4  2  0      
  3  5  1  0      
  5  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  2  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 11  1  0      
 14 17  1  0      
  2 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  2  0      
 21 22  1  0      
 22 23  1  0      
 23 18  1  0      
 22 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 27  1  0      
 27 23  2  0      
M  END
>  <Catalog Number> (1)
B2190

>  <Item Name> (1)
H 89 2HCl

>  <Formula> (1)
C20H20BrN3O2S.2HCl

>  <MolWeight> (1)
519.28

>  <CAS Number> (1)
130964-39-5

>  <Target> (1)
MAPK Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2190

$$$$

Untitled Document
  ChemDraw02252011432D
 28 30  0  0  0  0  0  0  0  0999 V2000
   -2.0624   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -2.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -2.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0624    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0624    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    2.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    2.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.8578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -2.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -2.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0624   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0624    2.8578    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8874    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0624    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8874   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0624   -2.8578    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0624   -2.8578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  5  7  2  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 10  6  2  0      
 11 12  2  0      
 12 13  1  0      
 13  8  1  0      
 11 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 12  1  0      
  3 18  1  6      
 19 20  1  0      
 20  4  1  0      
 19 21  1  0      
 21 22  1  0      
 16 23  1  0      
 15 24  1  0      
 14 25  1  0      
  1 26  1  0      
  2 27  2  0      
 21 28  1  0      
M  END
>  <Catalog Number> (1)
B2227

>  <Item Name> (1)
BI-D1870

>  <Formula> (1)
C19H23F2N5O2

>  <MolWeight> (1)
391.42

>  <CAS Number> (1)
501437-28-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2227

$$$$

Untitled Document
  ChemDraw02222014382D
 28 31  0  0  0  0  0  0  0  0999 V2000
    3.6920    2.3295    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4644    3.1226    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6639    3.3220    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2732   -1.6113    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3129   -2.0665    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0306   -0.2741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7353    0.0486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3053   -3.0945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6920   -2.7490    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0737   -2.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3204   -1.0384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7193   -2.6394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1134   -1.2659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0662   -1.3839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1059   -2.2940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2656   -0.5833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6995   -1.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9729    0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1724    0.7483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5000   -0.9203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4925   -1.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5459    1.1424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9448    1.5413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3184    1.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0985   -3.3220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5179    2.1349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8915    2.5290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7031   -0.7068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 27  1  0      
  2 27  1  0      
  3 27  1  0      
  4 10  1  0      
  4 11  1  0      
  4 14  1  0      
 12  5  1  0      
  5 13  1  0      
  5 15  1  0      
  6 16  1  0      
  6 18  1  0      
 16  7  2  0      
  7 19  1  0      
 15  8  2  0      
 25  8  1  0      
 21  9  1  0      
  9 25  2  0      
 10 12  1  0      
 13 11  1  0      
 14 16  1  0      
 15 17  1  0      
 17 20  1  0      
 17 21  2  0      
 19 18  1  0      
 22 18  2  0      
 19 23  2  0      
 24 22  1  0      
 23 26  1  0      
 26 24  2  0      
 24 27  1  0      
 20 28  1  0      
M  END
>  <Catalog Number> (1)
B2228

>  <Item Name> (1)
PF-4708671

>  <Formula> (1)
C19H21F3N6

>  <MolWeight> (1)
390.41

>  <CAS Number> (1)
1255517-76-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B2228

$$$$

Untitled Document
  ChemDraw02242013282D
 30 34  0  0  0  0  0  0  0  0999 V2000
    1.2026    2.2688    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3899    2.4671    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3026   -1.5813    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3646   -0.6252    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2164   -2.4018    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9836   -2.3830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9732    3.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6033    1.6702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7701    2.8370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4002    1.4566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9836    2.0401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5930    2.6806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0095    2.0973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6506    1.6557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4535    0.4294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1565    1.8272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9055    0.8710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0055   -0.1837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7085    1.2141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3534    0.2579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1097   -1.4098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5222   -2.1243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7506   -0.9683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8126   -0.0120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3427   -2.2106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9702   -2.7374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8276   -1.5430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6782   -2.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6481   -1.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4987   -3.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 13  1  0      
  1 14  1  0      
  2  7  1  0      
  2  8  1  0      
  2 12  1  0      
  5  3  1  0      
 21  3  1  0      
 23  3  1  0      
  4 21  1  0      
 24  4  2  0      
 26  5  2  0      
 29  6  1  0      
  6 30  2  0      
  7  9  1  0      
 10  8  1  0      
  9 11  1  0      
 11 10  1  0      
 12 13  1  0      
 14 16  1  0      
 14 17  2  0      
 15 18  1  0      
 19 15  1  0      
 15 20  2  0      
 16 19  2  0      
 20 17  1  0      
 23 18  2  0      
 18 24  1  0      
 21 22  2  0      
 22 25  1  0      
 22 26  1  0      
 25 27  1  0      
 28 25  2  0      
 27 29  2  0      
 28 30  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
M  END
>  <Catalog Number> (1)
B3252

>  <Item Name> (1)
Dorsomorphin

>  <Formula> (1)
C24H25N5O

>  <MolWeight> (1)
399.49

>  <CAS Number> (1)
866405-64-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B3252

$$$$

Untitled Document
  ChemDraw11151816232D
 36 37  0  0  0  0  0  0  0  0999 V2000
   -0.1363    4.5705    0.0000 Na  0  3  0  0  0  0  0  0  0  0  0  0
   -0.1363    3.5139    0.0000 Na  0  3  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.9983    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.4306    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -0.9983    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1249   -2.4271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2999    1.8596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0624   -0.2838    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -2.4271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9499   -3.8561    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.9499    1.8596    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.7124   -4.5705    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9499    0.4306    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.2838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.2838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4749   -0.9983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    1.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8874   -1.7127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0624    1.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7124   -1.7127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4749    1.8596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8874   -0.2838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    1.8596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4749   -2.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4749    0.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1249   -0.9983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0624    2.5740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7124   -0.2838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    2.5740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8874   -3.1416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2999    0.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7124    1.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7124   -3.1416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5374    1.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1249   -3.8561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  3 16  1  0      
  3 17  1  0      
  4 15  1  0      
  4 18  1  0      
  5 14  1  0      
  6 21  1  0      
 34  6  1  0      
  7 22  1  0      
 33  7  1  0      
  8 26  2  0      
  9 25  2  0      
 10 36  1  0      
 11 35  1  0      
 12 36  2  0      
 13 35  2  0      
 14 15  1  0      
 14 16  1  0      
 19 17  1  0      
 17 23  2  0      
 20 18  1  0      
 18 24  2  0      
 21 19  2  0      
 25 19  1  0      
 22 20  2  0      
 26 20  1  0      
 21 27  1  0      
 22 28  1  0      
 23 29  1  0      
 24 30  1  0      
 25 31  1  0      
 26 32  1  0      
 29 27  2  0      
 30 28  2  0      
 31 34  2  0      
 32 33  2  0      
 33 35  1  0      
 34 36  1  0      
M  CHG  4   1   1   2   1  10  -1  11  -1
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
V   35 34
V   36 35
M  END
>  <Catalog Number> (1)
B3300

>  <Item Name> (1)
Cromolyn sodium

>  <Formula> (1)
C23H14Na2O11

>  <MolWeight> (1)
512.33

>  <CAS Number> (1)
15826-37-6

>  <Target> (1)
Membrane Transporter/Ion Channel

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B3300

$$$$

Untitled Document
  ChemDraw02222013412D
 33 33  0  0  0  0  0  0  0  0999 V2000
   -2.8465    0.9176    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1275    2.3187    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6703    3.6725    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8752   -1.2067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0012   -0.1887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0648    0.6537    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5825    1.6993    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6281    1.1816    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.1104    0.1360    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5081    2.8636    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6724    2.9381    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7469    1.7737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8325    4.4813    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8613    3.8347    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.4792    3.5103    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4269   -1.8893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2137   -0.4347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4481    0.0580    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0502   -1.2163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1210   -0.4193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9027   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3678   -1.8685    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5849   -0.7721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3200   -0.3976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1909    0.4173    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3761    0.5463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5417   -1.5960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2336   -2.0453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9687   -1.6708    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0119   -0.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7469   -0.4723    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6956   -3.4539    0.0000 Na  0  3  0  0  0  0  0  0  0  0  0  0
   -2.0426   -4.4813    0.0000 Na  0  3  0  0  0  0  0  0  0  0  0  0
  1  6  1  6      
  1  7  1  0      
  1  8  1  6      
  1  9  2  0      
  2  7  1  1      
  2 10  1  0      
  2 11  1  1      
  2 12  2  0      
  3 10  1  1      
  3 13  1  1      
  3 14  1  0      
  3 15  2  0      
  4 19  1  0      
  4 20  1  0      
 17  5  1  6      
  6 21  1  0      
 19 16  1  6      
 17 18  1  0      
 17 19  1  0      
 18 20  1  0      
 20 21  1  1      
  4 22  1  6      
  5 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26  5  1  0      
 23 27  1  0      
 27 28  2  0      
 28 29  1  0      
 29 30  2  0      
 30 24  1  0      
 30 31  1  0      
M  CHG  4   8  -1  14  -1  32   1  33   1
M  END
>  <Catalog Number> (1)
B3304

>  <Item Name> (1)
ATP disodium salt

>  <Formula> (1)
C10H14N5Na2O13P3

>  <MolWeight> (1)
551.14

>  <CAS Number> (1)
987-65-5

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B3304

$$$$

Untitled Document
  ChemDraw02222011032D
 25 27  0  0  0  0  0  0  0  0999 V2000
   -0.2849   -1.0796    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0432    1.6698    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2910    1.1863    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6915    0.5956    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6362   -1.3352    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4526   -2.5002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1705    2.5480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2402    0.2546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5354   -0.0265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7471   -0.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5079   -0.8511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5502    1.0190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3321    0.8488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2634    0.3618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2081   -1.2873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5643   -0.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3674    1.1328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9637   -0.0744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8744    0.4819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9359   -0.8990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1804   -2.1118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6775    1.8972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6915    0.3139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8807   -2.5480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4946    2.0109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 10  1  0      
  1 11  1  0      
  2 12  2  0      
  3 14  1  0      
  4 19  1  0      
  5 20  1  0      
  6 21  1  0      
  7 22  2  0      
  8  9  1  0      
  8 10  1  0      
  8 12  1  0      
  8 13  1  6      
  9 11  1  0      
  9 14  2  0      
 10 16  2  0      
 11 15  2  0      
 12 17  1  0      
 14 18  1  0      
 15 20  1  0      
 15 21  1  0      
 16 19  1  0      
 17 19  2  0      
 17 22  1  0      
 18 20  2  0      
 18 23  1  0      
 21 24  2  0      
 22 25  1  0      
M  END
>  <Catalog Number> (1)
B3661

>  <Item Name> (1)
(+)-Usniacin

>  <Formula> (1)
C18H16O7

>  <MolWeight> (1)
344.32

>  <CAS Number> (1)
7562-61-0

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B3661

$$$$

Untitled Document
  ChemDraw08061413112D
 20 23  0  0  0  0  0  0  0  0999 V2000
    0.6974   -0.4133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4320    1.4951    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1886   -0.0419    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2525    2.0961    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2525    0.8942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4821    0.1877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540    1.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540    1.8666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4821   -1.0143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1886   -0.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0454   -0.4133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6892    1.4951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0973    0.7523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0973    2.2380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3276   -1.7409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7406   -1.2818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7406    1.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7406    1.8666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8797   -2.2380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5862   -2.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 11  2  0      
  2 12  2  0      
  6  3  1  0      
  3 10  1  0      
  4  8  1  0      
 12  4  1  0      
  5  6  2  0      
  5  7  1  0      
  5 12  1  0      
 11  6  1  0      
  8  7  1  0      
 13  7  2  0      
  8 14  2  0      
 10  9  1  0      
 11  9  1  0      
 15  9  2  0      
 10 16  2  0      
 17 13  1  0      
 14 18  1  0      
 19 15  1  0      
 16 20  1  0      
 18 17  2  0      
 20 19  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
M  END
>  <Catalog Number> (1)
B3672

>  <Item Name> (1)
Indirubin

>  <Formula> (1)
C16H10N2O2

>  <MolWeight> (1)
262.26

>  <CAS Number> (1)
479-41-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B3672

$$$$

Untitled Document
  ChemDraw08261417332D
 20 23  0  0  0  0  0  0  0  0999 V2000
    2.9427    0.1560    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8986   -1.7727    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0316    1.5481    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6419   -0.5898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6125    1.6275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0283    0.2145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4861    0.8595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8007    0.5044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1553   -0.5898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7637    1.3286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3111    0.8595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8255    0.2145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8986   -0.9477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5329    0.1244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4589    1.7727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2282    0.5685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1912    1.3927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6413    0.3375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9427    1.1055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4283    1.7505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 16  1  0      
  2 13  2  0      
  3  7  1  0      
 10  3  1  0      
  4 12  1  0      
 13  4  1  0      
  5 11  2  0      
 20  5  1  0      
  7  6  2  0      
  6  8  1  0      
  6  9  1  0      
  7 11  1  0      
 10  8  1  0      
  8 14  2  0      
  9 13  1  0      
 15 10  2  0      
 12 11  1  0      
 12 18  2  0      
 16 14  1  0      
 17 15  1  0      
 16 17  2  0      
 18 19  1  0      
 19 20  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
M  END
>  <Catalog Number> (1)
B3690

>  <Item Name> (1)
1-Azakenpaullone

>  <Formula> (1)
C15H10BrN3O

>  <MolWeight> (1)
328.16

>  <CAS Number> (1)
676596-65-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B3690

$$$$

Untitled Document
  ChemDraw05071514152D
 30 33  0  0  0  0  0  0  0  0999 V2000
    0.9898    1.9973    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4017   -1.4388    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4045    2.5868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4003    2.4120    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8920   -2.5868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8016   -0.8855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5751    1.4079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8025   -1.4839    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1637    2.1906    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6900    0.3578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5194   -0.8211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3869   -0.2961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2753    0.9472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6410   -1.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4078    0.4222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8225   -0.1673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5575    0.8828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1428    1.4723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2596   -1.9580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5784    1.6011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5792    1.5826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4459    2.1261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9782   -1.8712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5148    0.8648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2331    1.8858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1043    0.4501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8225    1.4711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7581    0.7532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2750   -1.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8282   -1.2247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  3  2  0      
  1  4  2  0      
  1  7  1  0      
  1 21  1  0      
  2 23  1  0      
  2 29  1  0      
  5 23  2  0      
 11  6  1  0      
 12  6  1  0      
 14  6  1  0      
  7 18  1  0      
  8 11  2  0      
 19  8  1  0      
 20  9  2  0      
  9 22  1  0      
 10 12  2  0      
 10 13  1  0      
 15 10  1  0      
 11 16  1  0      
 17 13  2  0      
 13 20  1  0      
 14 19  2  0      
 14 23  1  0      
 16 15  2  0      
 18 17  1  0      
 18 22  2  0      
 21 24  1  0      
 21 25  2  0      
 24 26  2  0      
 27 25  1  0      
 26 28  1  0      
 28 27  2  0      
 29 30  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
M  END
>  <Catalog Number> (1)
B4492

>  <Item Name> (1)
HS-173

>  <Formula> (1)
C21H18N4O4S

>  <MolWeight> (1)
422.46

>  <CAS Number> (1)
1276110-06-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4492

$$$$

Untitled Document
  ChemDraw02061512362D
 36 42  0  0  0  0  0  0  0  0999 V2000
    0.4432    0.5569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4432   -0.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1577   -0.6806    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8721   -0.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8721    0.5569    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1577    0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3414    0.8118    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8264    0.1444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3414   -0.5231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1577    1.7944    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8721    2.2069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8721    3.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1577    3.4444    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4432    3.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4432    2.2069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8721   -1.9181    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5866   -1.5056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5866   -0.6806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3011   -1.9181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0155   -1.5056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0155   -0.6806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3011   -0.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6286   -0.1286    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2931    0.6251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4726    0.5388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6468    0.0581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9824   -0.6955    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4975   -1.3630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8029   -0.7818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1384   -1.5354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6535   -2.2029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8330   -2.1166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6286   -2.6194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6286   -3.4444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9142   -3.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9891   -2.9566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  1  7  1  0      
  7  8  1  0      
  8  9  2  0      
  9  2  1  0      
  6 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15 10  1  0      
 16 17  1  0      
 17 18  2  0      
 18  4  1  0      
 17 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 18  1  0      
 21 23  1  0      
 23 24  1  0      
 24 25  2  0      
 25 22  1  0      
  8 26  1  0      
 26 27  1  0      
 27 28  1  0      
 27 29  1  0      
 29 30  1  0      
 30 31  1  0      
 31 32  1  0      
 32 28  1  0      
 33 34  1  0      
 34 35  1  0      
 35 33  1  0      
 31 36  1  0      
 35 36  1  0      
M  END
>  <Catalog Number> (1)
B4660

>  <Item Name> (1)
PI-3065

>  <Formula> (1)
C27H31FN6OS

>  <MolWeight> (1)
506.64

>  <CAS Number> (1)
955977-50-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4660

$$$$

Untitled Document
  ChemDraw08061414172D
 13 14  0  0  0  0  0  0  0  0999 V2000
   -1.4854   -1.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.1519   -1.6563    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4854   -0.1365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3623    0.2284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0564    0.4540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3623   -0.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0564   -0.7269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1801    0.7168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2082    1.1679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2282   -0.9304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0284    1.4307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6658    1.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8949   -0.6335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 13  1  0      
  2 10  2  0      
  5  3  1  0      
  3  7  1  0      
  5  4  1  0      
  6  4  1  0      
  4  8  2  0      
  9  5  2  0      
  7  6  2  0      
  6 10  1  0      
 11  8  1  0      
 12  9  1  0      
 10 13  1  0      
 11 12  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
M  END
>  <Catalog Number> (1)
B4688

>  <Item Name> (1)
3CAI

>  <Formula> (1)
C10H8ClNO

>  <MolWeight> (1)
193.63

>  <CAS Number> (1)
28755-03-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4688

$$$$

Untitled Document
  ChemDraw03042011362D
 69 73  0  0  0  0  0  0  0  0999 V2000
   -4.8908    4.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3074    4.0020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.3766    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7014    5.1914    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5163    5.3205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8373    4.0020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8373    3.1770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1228    2.7645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4083    3.1770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4083    4.0020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1228    4.4145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1228    5.2395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8373    5.6520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6939    2.7645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6939    1.9395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4083    1.5270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    1.3562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6040    1.7687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6040    2.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184    3.0062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    3.0062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    2.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184    3.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474    3.0062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4619    2.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474    3.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763    3.0062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4619    1.7687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763    1.3562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474    1.3562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    1.7687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8908    1.7687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763    0.5312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8908    0.1187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4619    0.1187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4619   -0.7063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -1.1188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763   -1.1188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -1.9438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.3563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -3.1813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -3.5938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -4.3083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0880   -4.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4142   -4.8551    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2007   -5.6520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1255   -3.4037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8400   -2.9912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8400   -2.1662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5545   -1.7537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2689   -2.1662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2689   -2.9912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5545   -3.4037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5545   -0.9287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2689   -0.5162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9834   -0.9287    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9834   -1.7537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8400    0.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5545    0.7213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2689    0.3088    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5545    1.5463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2689    1.9588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9834    1.5463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9834    0.7213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2689   -1.3412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7576   -0.7152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4275   -0.4057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0431    0.5223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2708   -5.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  1  0      
  4  5  2  0      
  5  1  1  0      
  3  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11  6  1  0      
 11 12  1  0      
 12 13  1  0      
  9 14  1  0      
 14 15  1  0      
 15 16  1  0      
 15 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 19 21  2  0      
 20 22  1  0      
 20 23  1  0      
 22 24  2  0      
 24 25  1  0      
 24 26  1  0      
 25 27  1  0      
 25 28  1  0      
 28 29  1  0      
 28 30  1  0      
 30 31  1  0      
 29 32  2  0      
 29 33  1  0      
 33 34  1  0      
 33 35  1  0      
 35 36  1  0      
 36 37  1  0      
 36 38  1  0      
 37 39  2  0      
 39 40  1  0      
 40 41  2  0      
 41 42  1  0      
 42 43  2  0      
 43 44  1  0      
 44 45  1  0      
 45 46  1  0      
 44 47  1  0      
 47 48  1  0      
 48 49  1  0      
 49 50  1  0      
 50 51  1  0      
 51 52  1  0      
 52 53  1  0      
 53 48  1  0      
 50 54  1  0      
 54 55  1  0      
 55 56  2  0      
 58 59  1  0      
 59 60  1  0      
 60 55  1  0      
 59 61  1  0      
 61 62  1  0      
 62 63  1  0      
 63 64  1  0      
 64 60  1  0      
 50 65  1  0      
 51 57  1  0      
 54 66  2  0      
 58 67  2  0      
 58 68  1  0      
 17 68  1  0      
 43 69  1  0      
M  END
>  <Catalog Number> (1)
B4786

>  <Item Name> (1)
Zotarolimus(ABT-578)

>  <Formula> (1)
C52H79N5O12

>  <MolWeight> (1)
966.21

>  <CAS Number> (1)
221877-54-9

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4786

$$$$

Untitled Document
  ChemDraw04181616472D
 23 25  0  0  0  0  0  0  0  0999 V2000
    1.9165    2.6623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7150    2.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9345    1.6595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9345   -1.2446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7150   -2.0398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3556   -0.6568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9165   -2.2473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6188    1.1065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1977    0.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3992    0.1037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1797    0.8990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5571   -0.8643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9782   -0.2765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3375   -1.6595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1797   -0.4840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5391   -1.8670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0399   -1.2793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5571    1.2793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1360    1.8670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7586    1.4868    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3195   -2.6623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8383   -1.4868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7767    0.4840    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  5  4  1  0      
  6  4  2  0      
  7  5  2  0      
  9  8  1  0      
 11  8  2  0      
 11 10  1  0      
 12  6  1  0      
 13  9  2  0      
 13 12  1  0      
 14  7  1  0      
 14 12  2  0      
 15 10  2  0      
 15 13  1  0      
 16 14  1  0      
 17 15  1  0      
 17 16  1  0      
 19  1  1  0      
 19  2  1  0      
 19  3  1  0      
 19 18  1  0      
 20 11  1  0      
 20 18  1  0      
 21 16  2  0      
 22 17  2  0      
 23 18  2  0      
M  END
>  <Catalog Number> (1)
B4787

>  <Item Name> (1)
SF1670

>  <Formula> (1)
C19H17NO3

>  <MolWeight> (1)
307.34

>  <CAS Number> (1)
345630-40-2

>  <Target> (1)
Cell Cycle/Checkpoint

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4787

$$$$

Untitled Document
  ChemDraw02242013542D
 28 31  0  0  0  0  0  0  0  0999 V2000
   -3.1926    1.9824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7801    1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9551    1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5426    1.9824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9551    2.6969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7801    2.6969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1926    3.4114    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5426    0.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7176    0.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1342   -0.0299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6908   -0.0299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2741   -0.6132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0092   -0.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8801    0.5762    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0653    0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4635    1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6528    1.4197    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7237   -0.6512    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2741   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5596   -1.8507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7312   -2.6577    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5517   -2.7439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8872   -1.9903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2372   -1.6372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0366   -3.4114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8571   -3.3251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1926   -2.5715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7077   -1.9040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  6  7  1  0      
  3  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15 11  1  0      
 14 16  1  0      
 15 17  2  0      
 13 18  2  0      
 12 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  1  0      
 22 23  1  0      
 23 19  1  0      
 20 24  1  0      
 22 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 28  1  0      
 28 23  2  0      
M  END
>  <Catalog Number> (1)
B4793

>  <Item Name> (1)
IM-12

>  <Formula> (1)
C22H20FN3O2

>  <MolWeight> (1)
377.41

>  <CAS Number> (1)
1129669-05-1

>  <Target> (1)
Stem Cell

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4793

$$$$

Untitled Document
  ChemDraw12191411482D
 27 29  0  0  0  0  0  0  0  0999 V2000
    0.8260   -2.5401    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.8354   -2.6339    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0852   -1.6476    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7881    1.5785    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9601   -0.7784    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159    0.0684    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8103    0.7191    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -0.9875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7881   -1.2450    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7048    0.4981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5772    1.1363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3214    0.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0661    1.5660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3435   -0.5698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1454   -0.9995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1126   -1.4162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6827    1.3574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9385    2.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7804   -0.8565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7607   -1.4764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6830   -1.9051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1716    1.7870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4274    2.6339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0929   -2.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0439    2.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0474   -0.3525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7279   -1.8931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 21  1  0      
  2 24  1  0      
 15  3  1  0      
 21  3  1  0      
  4 22  1  0      
  5 14  2  0      
 10  6  1  6      
  6 14  1  0      
  7 12  1  0      
  8  9  1  0      
  8 20  1  0      
  8 26  1  0      
  9 27  2  0      
 10 11  1  0      
 10 12  1  0      
 11 13  1  0      
 13 17  1  0      
 13 18  2  0      
 14 15  1  0      
 15 19  2  0      
 16 19  1  1      
 16 20  1  0      
 16 21  2  0      
 17 22  2  0      
 23 18  1  0      
 20 24  2  0      
 22 25  1  0      
 25 23  2  0      
 24 27  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
M  END
>  <Catalog Number> (1)
B4811

>  <Item Name> (1)
Afuresertib

>  <Formula> (1)
C18H17Cl2FN4OS

>  <MolWeight> (1)
427.32

>  <CAS Number> (1)
1047644-62-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4811

$$$$

Untitled Document
  ChemDraw04071517162D
 15 15  0  0  0  0  0  0  0  0999 V2000
    0.3521   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0651   -2.4775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7810   -2.0675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7840   -1.2426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0710   -0.8275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3550   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4941   -2.4825    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.3580   -0.8224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3550    0.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0681    0.4175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3609    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0652    1.2426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7781    1.6575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7752    2.4825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4941    1.2475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  6  1  2  0      
  3  7  1  0      
  6  8  1  0      
  8  9  1  0      
  9 10  1  0      
  9 11  2  0      
 10 12  1  0      
 12 13  1  0      
 13 14  1  0      
 13 15  2  0      
M  END
>  <Catalog Number> (1)
B4898

>  <Item Name> (1)
Bikinin

>  <Formula> (1)
C9H9BrN2O3

>  <MolWeight> (1)
273.08

>  <CAS Number> (1)
188011-69-0

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B4898

$$$$

Untitled Document
  ChemDraw12291616482D
 16 17  0  0  0  0  0  0  0  0999 V2000
   -0.7338    0.5436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0139    1.7614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4369    0.9753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6892    2.1930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6946    0.5050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0084    0.9367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4145    1.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6723   -0.3197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3263   -0.8225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2256   -1.5776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2773   -2.2317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0503   -1.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1176    2.2317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1176   -0.5889    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0080   -0.7864    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4200    0.8980    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0      
  4  2  2  0      
  6  1  2  0      
  6  2  1  0      
  6  5  1  0      
  7  3  2  0      
  7  4  1  0      
  8  5  2  0      
  9  8  1  0      
 11 10  2  0      
 12  9  2  0      
 12 10  1  0      
 13  7  1  0      
 14  9  1  0      
 15  8  1  0      
 15 10  1  0      
 16  5  1  0      
M  END
>  <Catalog Number> (1)
B5389

>  <Item Name> (1)
Mirin

>  <Formula> (1)
C10H8N2O2S

>  <MolWeight> (1)
220.25

>  <CAS Number> (1)
1198097-97-0

>  <Target> (1)
Cell Cycle/Checkpoint

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5389

$$$$

Untitled Document
  ChemDraw09191413352D
 25 28  0  0  0  0  0  0  0  0999 V2000
   -2.2842    2.0434    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.6397    0.8447    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2428   -0.4380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8468    0.4158    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2050    1.5113    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7690   -0.4563    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7498   -0.0893    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3961    0.5531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3254   -0.0466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9228    0.8484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2013   -0.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8047    1.4406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0832   -0.9340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0475    0.9628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5164   -1.0047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4947    0.6546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2585    1.8389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4443   -1.4180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7550   -1.5594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9485    1.0529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8304    1.6451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2057   -1.9727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3940   -2.0434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7912   -0.1855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2842   -0.5342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 21  1  0      
  2 14  2  0      
  3  7  1  0      
  3 24  1  0      
  4 24  2  0      
  5 12  1  0      
 14  5  1  0      
  6  9  1  0      
 15  6  2  0      
  7 11  1  0      
  8  9  2  0      
  8 10  1  0      
  8 14  1  0      
 11  9  1  0      
 12 10  1  0      
 16 10  2  0      
 11 13  2  0      
 12 17  2  0      
 13 15  1  0      
 13 18  1  0      
 19 15  1  0      
 20 16  1  0      
 17 21  1  0      
 18 22  2  0      
 23 19  2  0      
 21 20  2  0      
 22 23  1  0      
 24 25  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
M  END
>  <Catalog Number> (1)
B5488

>  <Item Name> (1)
BIO-acetoxime

>  <Formula> (1)
C18H12BrN3O3

>  <MolWeight> (1)
398.21

>  <CAS Number> (1)
667463-85-6

>  <Target> (1)
Stem Cell

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5488

$$$$

Untitled Document
  ChemDraw01281614272D
 25 26  0  0  0  0  0  0  0  0999 V2000
   -2.6140   -1.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6140    2.3975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4413   -0.7388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8290    2.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6044   -2.3975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1806   -2.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0440   -1.0379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5259    1.3823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2167   -1.8446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2590   -0.7841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6986    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3533   -1.3370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0863    0.0227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6986    0.2765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -0.2765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4836    0.3218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8713    1.0832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0017   -2.0984    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.3533    2.1890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0959   -0.0227    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0959    0.8747    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2590    1.6361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6563   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6563    1.3370    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1382   -1.0832    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0      
  4  2  1  0      
  6  5  2  0      
  9  5  1  0      
  9  7  2  0      
 10  7  1  0      
 11  8  1  0      
 12  6  1  0      
 12 10  2  0      
 13 10  1  0      
 13 11  1  0      
 14 13  1  0      
 15 14  2  0      
 16 11  1  0      
 17 14  1  0      
 18  9  1  0      
 19  8  3  0      
 20 15  1  0      
 21 16  2  0      
 22 17  2  0      
 23  3  1  0      
 23 16  1  0      
 24  4  1  0      
 24 17  1  0      
 25 12  1  0      
 25 15  1  0      
M  END
>  <Catalog Number> (1)
B5663

>  <Item Name> (1)
SC 79

>  <Formula> (1)
C17H17ClN2O5

>  <MolWeight> (1)
364.78

>  <CAS Number> (1)
305834-79-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5663

$$$$

Untitled Document
  ChemDraw08271509222D
 32 36  0  0  0  0  0  0  0  0999 V2000
    1.7297   -1.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1044   -3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8170   -3.5886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3372    0.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6453   -0.0908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6693    1.2396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9774    0.6644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8245   -1.9387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2572    1.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3596   -2.2642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6656    3.5052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8252   -0.1808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1082   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6416    2.1748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5371   -2.3544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5333   -3.1794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3956   -1.9321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9737    2.9300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4931   -0.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8215    2.0848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2534   -1.9452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2459   -3.5952    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2572   -1.1202    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9698   -1.5360    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9660   -2.3610    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4857    3.5952    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3335    2.7500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9698    2.0413    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3131   -1.1113    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7946    2.8475    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9089   -1.6486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4894    1.3296    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  3  2  2  0      
  6  4  1  0      
  7  5  1  0      
 12  4  1  0      
 12  5  1  0      
 13  2  1  0      
 13  8  2  0      
 14  9  2  0      
 15  8  1  0      
 16  3  1  0      
 16 15  2  0      
 17 10  2  0      
 17 13  1  0      
 18 14  1  0      
 19 12  1  0      
 20 14  1  0      
 21 15  1  0      
 22 16  1  0      
 23 21  1  0      
 24 21  1  0      
 25 21  1  0      
 26 11  2  0      
 26 18  1  0      
 27 11  1  0      
 27 20  2  0      
 28  9  1  0      
 29 17  1  0      
 29 19  2  0      
 30 18  2  0      
 30 28  1  0      
 31  1  1  0      
 31 10  1  0      
 31 19  1  0      
 32  6  1  0      
 32  7  1  0      
 32 20  1  0      
M  END
>  <Catalog Number> (1)
B5815

>  <Item Name> (1)
LY2584702

>  <Formula> (1)
C21H19F4N7

>  <MolWeight> (1)
445.42

>  <CAS Number> (1)
1082949-67-4

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5815

$$$$

Untitled Document
  ChemDraw08271509442D
 31 35  0  0  0  0  0  0  0  0999 V2000
   -0.1908    1.5221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2370   -0.7826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8098   -1.4884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8394   -0.0597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9850   -1.4713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -0.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1391   -1.3860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7119   -0.6802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9166   -2.1259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1687    1.0644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0737    2.8146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.6972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7415   -2.1088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5874   -0.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -1.4201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8871   -0.6972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8690    1.3689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2962    2.0747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0442    1.3860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6351   -0.0085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6646   -1.4372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1687   -2.8146    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4082    0.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0994    1.8865    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8985    2.7975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6465    2.1088    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6170    0.6802    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4599    0.0085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2374   -0.7314    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2670   -2.1600    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9136    1.1244    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  2  2  0      
  4  2  1  0      
  5  3  1  0      
  6  4  2  0      
  8  7  2  0      
 12  1  1  6      
 13  7  1  0      
 13  9  2  0      
 14  5  2  0      
 14  6  1  0      
 15  9  1  0      
 16  8  1  0      
 16 15  2  0      
 18 17  2  0      
 19 17  1  0      
 20 12  1  0      
 21 15  1  0      
 22 13  1  0      
 23 10  2  0      
 23 17  1  0      
 24 10  1  0      
 24 18  1  0      
 25 11  2  0      
 25 18  1  0      
 26 11  1  0      
 26 19  2  0      
 27 12  1  0      
 27 19  1  0      
 28 16  1  0      
 28 20  2  0      
 29 14  1  0      
 29 20  1  0      
 29 21  1  0      
 30 21  2  0      
 12 31  1  1      
M  END
>  <Catalog Number> (1)
B5831

>  <Item Name> (1)
Acalisib (GS-9820) 

>  <Formula> (1)
C21H16FN7O

>  <MolWeight> (1)
401.4

>  <CAS Number> (1)
870281-34-8

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5831

$$$$

Untitled Document
  ChemDraw08271510402D
 21 23  0  0  0  0  0  0  0  0999 V2000
    0.0688   -1.1677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0398   -2.7462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3084   -2.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1586    1.9563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6648    1.9051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6288   -2.1686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2473    0.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8678   -0.9620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6146    1.2689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5761    0.4790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4454   -1.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0322    1.1664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0890   -0.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8621    0.1209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8054    2.0588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3494    2.7462    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2615   -1.4299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4381    1.3201    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8269    0.9452    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5496   -0.3351    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6288    2.1100    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  3  2  1  0      
  5  4  2  0      
  6  2  2  0      
  8  1  1  0      
  9  4  1  0      
  9  7  2  0      
 10  7  1  0      
 11  3  2  0      
 11  8  1  0      
 12  5  1  0      
 12 10  2  0      
 13  8  2  0      
 13 10  1  0      
 14 13  1  0      
 16 15  2  0      
 17  6  1  0      
 17 11  1  0      
 18  9  1  0      
 18 15  1  0      
 19 12  1  0      
 19 14  2  0      
 20 14  1  0      
 21 15  1  0      
M  END
>  <Catalog Number> (1)
B5838

>  <Item Name> (1)
BX517(PDK1 inhibitor2)

>  <Formula> (1)
C15H14N4O2

>  <MolWeight> (1)
282.3

>  <CAS Number> (1)
850717-64-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5838

$$$$

Untitled Document
  ChemDraw08271509462D
 28 31  0  0  0  0  0  0  0  0999 V2000
    1.0804   -0.6278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765   -1.8714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7984   -1.0342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0944   -2.2778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5093    1.4043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8054    2.6478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524    2.6721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7774    1.4407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2273    1.8107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5233    3.0542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7633    3.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4883    1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3695   -1.0464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8054   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3555    0.1850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0804    1.4164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3485    1.4285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3485   -0.6400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0734    0.5914    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3555    0.6036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3695    1.8349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7984    1.8228    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0594    1.8471    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5233   -2.2656    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.2343   -1.8471    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.5303   -3.0906    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2343    2.6356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4813    2.6842    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0      
  4  2  2  0      
  9  5  1  0      
 10  6  1  0      
 11  7  1  0      
 12  8  1  0      
 13  1  2  0      
 13  2  1  0      
 14  3  2  0      
 14  4  1  0      
 18 13  1  0      
 18 15  1  0      
 19 15  2  0      
 19 16  1  0      
 20 15  1  0      
 20 17  2  0      
 21 16  2  0      
 21 17  1  0      
 22  5  1  0      
 22  6  1  0      
 22 16  1  0      
 23  7  1  0      
 23  8  1  0      
 23 17  1  0      
 24 14  1  0      
 25 24  1  0      
 26 24  2  0      
 27  9  1  0      
 27 10  1  0      
 28 11  1  0      
 28 12  1  0      
M  CHG  2  24   1  25  -1
M  END
>  <Catalog Number> (1)
B5853

>  <Item Name> (1)
MHY1485

>  <Formula> (1)
C17H21N7O4

>  <MolWeight> (1)
387.39

>  <CAS Number> (1)
326914-06-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5853

$$$$

Untitled Document
  ChemDraw11051510152D
 34 37  0  0  0  0  0  0  0  0999 V2000
    0.1105    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.0938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.8563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.0938    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.0938    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.6188    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.8563    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.6188    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.0938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.0938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.6188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    0.9207    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  6  4  1  0      
  7  5  1  0      
 14  1  1  6      
 15  8  2  0      
 15  9  1  0      
 16 10  2  0      
 16 11  1  0      
 17 10  1  0      
 17 12  2  0      
 18 11  2  0      
 18 12  1  0      
 19  8  1  0      
 19 14  1  0      
 20  9  2  0      
 21 13  1  0      
 21 20  1  0      
 22 13  2  0      
 23 19  2  0      
 23 20  1  0      
 24 15  1  0      
 25 16  1  0      
 26 17  1  0      
 27 14  1  0      
 27 18  1  0      
 28  2  1  0      
 28  3  1  0      
 28 24  1  0      
 29  4  1  0      
 29  5  1  0      
 29 22  1  0      
 30 21  2  0      
 31 24  2  0      
 32  6  1  0      
 32  7  1  0      
 33 22  1  0      
 33 23  1  0      
 14 34  1  1      
M  END
>  <Catalog Number> (1)
B5950

>  <Item Name> (1)
AZD8186

>  <Formula> (1)
C24H25F2N3O4

>  <MolWeight> (1)
457.47

>  <CAS Number> (1)
1627494-13-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B5950

$$$$

Untitled Document
  ChemDraw02021615032D
 29 33  0  0  0  0  0  0  0  0999 V2000
   -2.6187    2.3862    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8558    1.5960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2901    0.9956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4872    1.1853    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2501    1.9755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8158    2.5759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4472    2.1652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9215    0.5848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1586   -0.2054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5928   -0.8058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2100   -0.6161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4472    0.1741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1186    0.7745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2501    0.3638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8158   -0.2367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6187   -0.0469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8558    0.7433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2901    1.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4872    1.1540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3578    2.1659    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5967    2.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0587    1.8590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8300   -1.5960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6403   -2.3989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0398   -1.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6329   -1.7857    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8226   -0.9828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4575   -1.7612    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8700   -2.5759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  5  7  1  1      
  4  8  1  0      
  8  9  1  0      
  9 10  2  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13  8  2  0      
 12 14  1  0      
 14 15  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 14  2  0      
 18 20  1  0      
 20 21  1  0      
 21 22  2  0      
 22 19  1  0      
 10 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 23  1  0      
 26 27  2  0      
 26 28  2  0      
 26 29  1  1      
 26 23  1  6      
M  END
>  <Catalog Number> (1)
B6007

>  <Item Name> (1)
AZD6738

>  <Formula> (1)
C20H24N6O2S

>  <MolWeight> (1)
412.51

>  <CAS Number> (1)
1352226-88-0

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B6007

$$$$

Untitled Document
  ChemDraw12281615102D
 30 33  0  0  0  0  0  0  0  0999 V2000
    3.1496   -1.5193    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3326   -1.6338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7597   -1.0402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9032   -0.2278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2715    0.3028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3723    1.1216    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7136    1.6183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5119   -0.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9450   -2.3621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3064   -3.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1326   -2.2186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0181   -1.4016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2532   -1.0923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1387   -0.2752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6261    0.0341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7406    0.8511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5054    1.1604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6200    1.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848    2.2868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0351    1.7791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1496    2.5961    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4993    3.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9697    2.4851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2049    2.1758    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0903    1.3588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2764   -0.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1619   -1.2906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3970   -1.5999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2825   -2.4169    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4823   -2.7263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  7  1  0      
  5  8  1  6      
  2  9  1  0      
  9 10  1  0      
  9 11  1  0      
 11 12  2  0      
  3 12  1  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 19 21  1  0      
 19 22  1  0      
 18 23  2  0      
 23 24  1  0      
 24 25  2  0      
 16 25  1  0      
 15 26  2  0      
 26 27  1  0      
 27 28  2  0      
 13 28  1  0      
 28 29  1  0      
 29 30  2  0      
 11 30  1  0      
M  END
>  <Catalog Number> (1)
B6099

>  <Item Name> (1)
LY3023414

>  <Formula> (1)
C23H26N4O3

>  <MolWeight> (1)
406.48

>  <CAS Number> (1)
1386874-06-1

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B6099

$$$$

Untitled Document
  ChemDraw12291614262D
 25 28  0  0  0  0  0  0  0  0999 V2000
    3.0893   -0.5634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4601    0.5568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2703   -0.6628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5012   -0.4010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9969    0.2585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5100   -1.7201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1192   -2.8403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6020    2.9398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3589    0.4574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6823   -0.3016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6735    1.0175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1866   -0.9611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4426   -2.0813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1691    1.6770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8046   -2.2802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1280   -1.5212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0144   -2.3797    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3002   -2.9398    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9268    2.4656    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2615    2.4441    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8545    1.1169    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6323   -0.8617    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9940    1.6637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9469   -1.4218    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615   -1.9819    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0      
  5  4  2  0      
  9  2  1  0      
 10  4  1  0      
 10  9  2  0      
 11  5  1  0      
 12  6  2  0      
 12 10  1  0      
 13  7  1  0      
 14 11  1  0      
 16 15  1  0      
 17  6  1  0      
 17 15  1  0      
 18  7  1  0      
 18 15  2  0      
 19  8  2  0      
 19 14  1  0      
 20  8  1  0      
 21  9  1  0      
 21 11  2  0      
 22 12  1  0      
 22 16  2  0      
 23 14  2  0      
 23 20  1  0      
 24  3  1  0      
 24 13  1  0      
 24 16  1  0      
 25 13  2  0      
M  END
>  <Catalog Number> (1)
B6114

>  <Item Name> (1)
CC-115

>  <Formula> (1)
C16H16N8O

>  <MolWeight> (1)
336.35

>  <CAS Number> (1)
1228013-15-7

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B6114

$$$$

Untitled Document
  ChemDraw01171715222D
 24 27  0  0  0  0  0  0  0  0999 V2000
    1.0001    0.7321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6198    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2044   -0.0367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6483    0.6587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2680    1.3908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5562    1.4275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3453   -2.2331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7892   -1.5377    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4089   -0.8056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5847   -0.7688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1408   -1.4642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5211   -2.1964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7256   -2.9652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8243    0.7688    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4091    2.2698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0288    1.5377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2046    1.5010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7607    2.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1410    2.9285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9652    2.9652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8527   -0.1101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6769   -0.1469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3723   -0.5907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4091    0.2334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  1  6  2  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 10 11  2  0      
 11 12  1  0      
  7 12  2  0      
  3 10  1  0      
  7 13  1  0      
  1 14  1  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18 19  2  0      
 19 20  1  0      
 15 20  2  0      
 14 17  1  0      
 22 23  1  0      
 23 24  1  0      
 22 24  1  0      
 21 22  1  0      
  9 21  1  0      
M  END
>  <Catalog Number> (1)
B6160

>  <Item Name> (1)
PIK-III

>  <Formula> (1)
C17H17N7

>  <MolWeight> (1)
319.36

>  <CAS Number> (1)
1383716-40-2

>  <Target> (1)
Ubiquitination/Proteasome

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B6160

$$$$

Untitled Document
  ChemDraw01181709492D
 29 32  0  0  0  0  0  0  0  0999 V2000
    1.4289   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.6812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.6812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.2687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  1  3  2  0      
  2  4  2  0      
  4  5  1  0      
  5  6  2  0      
  3  6  1  0      
  8  9  1  0      
  9 10  1  0      
  7 10  1  0      
  1  7  1  0      
  2  8  1  0      
  9 11  2  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15 16  1  0      
 16 17  1  0      
 12 17  1  0      
 19 20  1  0      
 20 21  2  0      
 21 22  1  0      
 22 23  2  0      
 23 24  1  0      
 19 24  2  0      
 25 26  1  0      
 26 27  1  0      
 23 26  1  0      
  5 20  1  0      
 12  8  1  1      
 15 18  1  6      
 18 28  1  0      
 26 29  1  0      
M  END
>  <Catalog Number> (1)
B6171

>  <Item Name> (1)
CC-223

>  <Formula> (1)
C21H27N5O3

>  <MolWeight> (1)
397.47

>  <CAS Number> (1)
1228013-30-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B6171

$$$$

Untitled Document
  ChemDraw09171413152D
 20 23  0  0  0  0  0  0  0  0999 V2000
    2.4637    1.7769    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.9815   -2.1672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6036    0.8003    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3406   -1.8101    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3267   -0.1199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4728    0.0023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6899    0.6027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7296   -0.8211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1149    1.1714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0667   -0.5466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0079   -1.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4326   -1.5733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4699    0.8162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3200    1.9537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -0.1942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6770   -1.8074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6749    1.5985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1000    2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4637   -0.6484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4049   -1.4550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 17  1  0      
  2 12  2  0      
  3  6  1  0      
  9  3  1  0      
  4 11  1  0      
 12  4  1  0      
  6  5  2  0      
  5  7  1  0      
  5  8  1  0      
  6 10  1  0      
  9  7  1  0      
  7 13  2  0      
  8 12  1  0      
 14  9  2  0      
 11 10  1  0      
 15 10  2  0      
 11 16  2  0      
 17 13  1  0      
 18 14  1  0      
 19 15  1  0      
 16 20  1  0      
 17 18  2  0      
 20 19  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
M  END
>  <Catalog Number> (1)
B6720

>  <Item Name> (1)
Kenpaullone

>  <Formula> (1)
C16H11BrN2O

>  <MolWeight> (1)
327.18

>  <CAS Number> (1)
142273-20-9

>  <Target> (1)
Cell Cycle/Checkpoint

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B6720

$$$$

Untitled Document
  ChemDraw09171416202D
 23 26  0  0  0  0  0  0  0  0999 V2000
   -2.4980    0.7768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4980   -2.0974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2840   -0.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3903   -0.1996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8109    0.0557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6635    0.7493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9173   -0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5378    0.4940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0108    0.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4314   -1.1122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5161   -0.0184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7698   -1.3676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0955   -1.5867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2776    1.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5916   -0.4549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5894    1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0647    0.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8045    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1185   -0.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2968   -1.8420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3517    1.8090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9711   -1.6229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9994    2.0974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 18  2  0      
  2 22  2  0      
  3  4  1  0      
  5  3  1  0      
  3 10  1  6      
  7  4  1  0      
  4  8  1  1      
  5  6  1  0      
  5 11  1  6      
  9  6  1  0      
 14  6  1  0      
  6 16  1  1      
 12  7  1  0      
 15  7  1  0      
  7 17  1  6      
  8  9  1  0      
 10 13  1  0      
 18 11  1  0      
 13 12  1  0      
 12 20  2  0      
 14 18  1  0      
 14 21  2  0      
 19 15  1  0      
 22 19  1  0      
 20 22  1  0      
 21 23  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
M  END
>  <Catalog Number> (1)
B7431

>  <Item Name> (1)
Z-Guggulsterone

>  <Formula> (1)
C21H28O2

>  <MolWeight> (1)
312.45

>  <CAS Number> (1)
39025-23-5

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B7431

$$$$

Untitled Document
  ChemDraw01181713472D
 34 38  0  0  0  0  0  0  0  0999 V2000
    1.2367   -3.7602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0576   -3.8424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5393   -3.1726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2001   -2.4206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3792   -2.3383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0399   -1.5863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2191   -1.5041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2626   -2.1739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0766   -2.9259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8975   -3.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5269   -2.2746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3593   -3.0824    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8105   -1.8656    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2790   -1.9353    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5398    0.5946    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2951    0.2627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3853   -0.5573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7202   -1.0455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9649   -0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8747    0.1064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9144   -3.6928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3615   -0.0822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1202   -0.7520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9411   -0.6698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2803    0.0822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7986    0.7520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0223    0.6698    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1378    1.5041    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9587    1.5863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2980    2.3383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1188    2.4206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4581    3.1726    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9764    3.8424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2790    3.2548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  2  0      
  1 10  1  0      
  5 10  1  0      
 11 12  1  0      
 11 13  1  0      
  3 12  1  0      
  4 13  1  0      
 11 14  2  0      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 15 20  1  0      
 13 18  1  0      
 12 21  1  0      
 22 23  1  0      
 23 24  2  0      
 24 25  1  0      
 25 26  2  0      
 26 27  1  0      
 22 27  2  0      
 29 30  1  0      
 30 31  1  0      
 28 29  1  0      
 32 33  1  0      
 32 34  1  0      
 31 32  1  0      
 26 28  1  0      
  7 23  1  0      
M  END
>  <Catalog Number> (1)
B7822

>  <Item Name> (1)
AZD0156

>  <Formula> (1)
C26H31N5O3

>  <MolWeight> (1)
461.56

>  <CAS Number> (1)
1821428-35-6

>  <Target> (1)
DNA Damage/DNA Repair

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B7822

$$$$

Untitled Document
  ChemDraw06201709342D
 28 32  0  0  0  0  0  0  0  0999 V2000
   -2.4815    2.4889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6746    2.6604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1225    2.0473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3775    1.2627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1844    1.0912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7365    1.7043    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0336    3.1020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9725   -0.1350    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4205   -0.7481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6135   -0.5766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3586    0.2080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106    0.8211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7176    0.6496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9461   -1.0615    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5336    0.2080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0185    0.8211    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8254    0.6496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0804   -0.1350    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5283   -0.7481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2786   -0.5766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7833   -1.5327    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2313   -2.1458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4862   -2.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2932   -3.1020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8452   -2.4889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5903   -1.7043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0336   -1.3001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2489   -1.5551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  1  6  2  0      
  1  7  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
  8 13  1  0      
 15 16  2  0      
 16 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 14 20  1  0      
 15 20  1  0      
 10 14  2  0      
 11 15  1  0      
 21 22  1  0      
 22 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 21 26  1  0      
 19 21  1  0      
  9 27  1  0      
  9 28  1  0      
  4 17  1  0      
M  END
>  <Catalog Number> (1)
B7826

>  <Item Name> (1)
GDC-0084

>  <Formula> (1)
C18H22N8O2

>  <MolWeight> (1)
382.42

>  <CAS Number> (1)
1382979-44-3

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B7826

$$$$

Untitled Document
  ChemDraw09251413552D
 34 38  0  0  0  0  0  0  0  0999 V2000
   -3.5368    2.6312    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6753   -0.7769    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9356    3.3219    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2275    2.2324    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7740   -3.3219    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3405    0.5591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1380    1.9405    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7740   -1.7268    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7740    0.6659    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4647   -0.5304    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8461    1.8623    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5368    0.6659    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2275    1.8623    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1380    0.5591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9417    1.2498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5368    1.2498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3405    1.9405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9417   -0.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1441   -0.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6753    0.5136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0832   -0.5304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0832    0.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7740   -0.9292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8461    3.0300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4647   -2.1256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0832   -2.1256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9218    1.2721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4647   -2.9232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0832   -2.9232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4647    0.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1554    0.6659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1554    1.4635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8461    0.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5368    1.4635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  3  2  0      
  1  4  2  0      
  1  7  1  0      
  1 24  1  0      
  2 19  1  0      
 21  2  1  0      
  5 28  1  0      
 29  5  1  0      
  6 14  1  0      
  6 15  1  0      
  6 18  1  0      
 16  7  1  0      
  7 17  1  0      
  8 23  1  0      
  8 25  1  0      
  8 26  1  0      
 22  9  2  0      
 30  9  1  0      
 10 23  1  0      
 30 10  2  0      
 11 32  2  0      
 11 34  1  0      
 12 33  1  0      
 12 34  2  0      
 13 34  1  0      
 14 16  1  0      
 17 15  1  0      
 18 19  1  0      
 19 20  2  0      
 20 22  1  0      
 20 27  1  0      
 21 22  1  0      
 23 21  2  0      
 28 25  1  0      
 26 29  1  0      
 30 31  1  0      
 31 32  1  0      
 31 33  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
V   30 29
V   31 30
V   32 31
V   33 32
V   34 33
M  END
>  <Catalog Number> (1)
B8001

>  <Item Name> (1)
GNE-477

>  <Formula> (1)
C21H28N8O3S2

>  <MolWeight> (1)
504.63

>  <CAS Number> (1)
1032754-81-6

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B8001

$$$$

Untitled Document
  ChemDraw12251810312D
 35 39  0  0  0  0  0  0  0  0999 V2000
   -4.3625    3.8715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7632    3.1504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3390    2.4428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5141    2.4563    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1134    3.1774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5376    3.8851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0900    1.7487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2651    1.7622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8409    1.0546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0160    1.0682    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5918    0.3606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9926   -0.3606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5684   -1.0682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2565   -1.0546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6572   -0.3335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2330    0.3741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6807   -1.7622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -2.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7041   -3.1910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5290   -3.1774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9297   -2.4563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5056   -1.7487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5449   -2.4969    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9532   -3.8851    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7781   -3.8715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1788   -3.1504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7546   -2.4428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9828   -2.9656    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0556   -2.1438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2965   -1.8207    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5757   -3.5393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2830   -0.9958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8567   -0.4029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6901   -0.4221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7632   -1.7197    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  1  1  0      
  4  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  2  0      
 14 15  1  0      
 15 16  2  0      
 16 11  1  0      
 14 17  1  0      
 17 18  2  0      
 18 19  1  0      
 19 20  2  0      
 20 21  1  0      
 21 22  2  0      
 22 17  1  0      
 18 23  1  0      
 20 24  1  0      
 24 25  2  0      
 25 26  1  0      
 26 27  2  0      
 27 21  1  0      
 26 28  1  0      
 28 29  1  0      
 29 30  1  0      
 30 27  1  0      
 28 31  1  0      
 30 32  1  0      
 32 33  1  0      
 32 34  1  0      
 29 35  2  0      
M  END
>  <Catalog Number> (1)
B8328

>  <Item Name> (1)
AZD1390

>  <Formula> (1)
C27H32FN5O2

>  <MolWeight> (1)
477.57

>  <CAS Number> (1)
2089288-03-7

>  <Target> (1)
Cell Cycle/Checkpoint

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=B8328

$$$$

Untitled Document
  ChemDraw04061709522D
 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5283   -1.9233    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9954   -1.2935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2744   -0.5171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7415    0.1127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9296   -0.0339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6507   -0.8103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1612   -0.9570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5198   -1.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3372   -1.5885    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1295   -2.4268    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7570   -0.3863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6456    0.4311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0812    0.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0654    1.6333    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5052    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8829    1.7447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2414    1.0017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0642    0.9408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5283    1.6228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1698    2.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3470    2.4268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4839   -0.7767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2269   -0.4181    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1836   -1.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  8 10  2  0      
  7 11  2  0      
 11 12  1  0      
 12 13  2  0      
 13 14  1  0      
 14 15  1  0      
 14 16  1  0      
 16 17  2  0      
 12 17  1  0      
 17 18  1  0      
 18 19  2  0      
 19 20  1  0      
 20 21  2  0      
 16 21  1  0      
 11 22  1  0      
  9 22  1  0      
 22 23  2  0      
  6 24  2  0      
  2 24  1  0      
M  END
>  <Catalog Number> (1)
C4009

>  <Item Name> (1)
CP21R7

>  <Formula> (1)
C19H15N3O2

>  <MolWeight> (1)
317.3

>  <CAS Number> (1)
125314-13-8

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=C4009

$$$$

Untitled Document
  ChemDraw07201713402D
 24 23  0  0  0  0  0  0  0  0999 V2000
   -5.9502   -5.4344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1456   -5.2520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9011   -4.4641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0965   -4.2818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8521   -3.4938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0475   -3.3115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8031   -2.5235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9985   -2.3412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7541   -1.5532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1485   -0.9930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3439   -0.8107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0995   -0.0227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7051    0.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9495    0.9476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7541    1.1299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9985    1.9179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8031    2.1002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0475    2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8521    3.0705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0965    3.8584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9011    4.0408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1456    4.8287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5854    5.4344    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9502    5.0110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  1  0      
  3  4  1  0      
  4  5  1  0      
  5  6  1  0      
  6  7  1  0      
  7  8  1  0      
  8  9  1  0      
  9 10  2  0      
 10 11  1  0      
 11 12  1  0      
 12 13  1  0      
 13 14  1  0      
 14 15  1  0      
 15 16  1  0      
 16 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 20 21  1  0      
 21 22  1  0      
 22 23  2  0      
 22 24  1  0      
M  END
>  <Catalog Number> (1)
C5638

>  <Item Name> (1)
13(Z)-Docosenoic Acid

>  <Formula> (1)
C22H42O2

>  <MolWeight> (1)
338.57

>  <CAS Number> (1)
112-86-7

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=C5638

$$$$

Untitled Document
  ChemDraw09301915052D
  9  8  0  0  0  0  0  0  0  0999 V2000
   -0.8181   -0.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3987   -1.4328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.0040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.0040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6430   -0.7303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8181    0.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6430    0.7303    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3987    1.4328    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8318   -0.7065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  3  4  1  0      
  4  1  1  0      
  1  5  1  0      
  3  6  1  0      
  6  7  1  0      
  6  8  2  0      
  3  9  1  1      
M  END
>  <Catalog Number> (1)
C6104

>  <Item Name> (1)
L-Leucine

>  <Formula> (1)
C6H13NO2

>  <MolWeight> (1)
131.17

>  <CAS Number> (1)
61-90-5

>  <Target> (1)
Others

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=C6104

$$$$

Untitled Document
  ChemDraw02272010452D
 21 21  0  0  0  0  0  0  0  0999 V2000
    1.8518   -0.7179    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6114   -1.4273    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5077    0.0189    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3387   -1.4067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8578    0.7110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4422   -0.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6827    0.7076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6173    0.0017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0982    1.4204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2019   -0.7110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9232    1.4169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6233   -0.7076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0388   -1.4204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8637   -1.4170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3387    2.1297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2733   -0.7008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2791   -2.1297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0982   -0.6974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1042   -2.1263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5137   -1.4101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3328    0.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  6  1  1  6      
  2 10  2  0      
  3 18  1  0      
  3 21  1  0      
  4 20  1  0      
  5  6  1  0      
  5  7  1  0      
  6  8  1  0      
  7  9  1  0      
  8 10  1  0      
  9 11  1  0      
 10 12  1  0      
 11 15  1  0      
 12 13  1  0      
 13 14  1  0      
 14 16  2  0      
 14 17  1  0      
 16 18  1  0      
 19 17  2  0      
 18 20  2  0      
 20 19  1  0      
M  END
>  <Catalog Number> (1)
N1353

>  <Item Name> (1)
6-gingerol

>  <Formula> (1)
C17H26O4

>  <MolWeight> (1)
294.39

>  <CAS Number> (1)
23513-14-6

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1353

$$$$

Untitled Document
  ChemDraw03032016362D
 23 25  0  0  0  0  0  0  0  0999 V2000
   -1.8562    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2687    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8562    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0312    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6188    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0312    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6188    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2062    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6187    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2062    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6187   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4437   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4437    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2062   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6187   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4437   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8562   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8562   -2.8579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6812   -1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6187    2.8579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6188    2.1434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0937   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0937    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  1  1  0      
  4  7  1  0      
  7  8  1  0      
  8  9  2  0      
  9 10  1  0      
 10  5  1  0      
  8 11  1  0      
 11 12  2  0      
 13  9  1  0      
 11 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 12  1  0      
 16 18  1  0      
 19 17  1  0      
  6 20  1  0      
 10 21  2  0      
 19 22  1  0      
  2 23  1  0      
M  END
>  <Catalog Number> (1)
N1358

>  <Item Name> (1)
Isorhamnetin

>  <Formula> (1)
C16H12O7

>  <MolWeight> (1)
316.27

>  <CAS Number> (1)
480-19-3

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1358

$$$$

Untitled Document
  ChemDraw07031416192D
 29 32  0  0  0  0  0  0  0  0999 V2000
   -2.6917    0.7853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3462   -0.5041    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9293   -1.0901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4489   -1.3675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1905   -1.8475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5967   -2.2746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7218    2.0400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4363    1.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0751    1.8264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6498    0.8306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4876    1.1120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2373    0.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2741    0.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4404   -0.0974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8295    2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0908    2.1297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2845    1.3255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8574   -0.2683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8206   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2269   -0.8943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8679    0.7421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6543   -0.0547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6071   -1.2641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8102   -1.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9874    0.0151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6770   -1.4388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3770   -2.1894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9874   -1.6340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1801   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 21  1  1  0      
  1 25  1  0      
  2 22  1  0      
 25  2  1  0      
  3 18  1  0      
  3 26  1  0      
  4 20  1  0      
  4 27  1  0      
  5 23  1  0      
  5 28  1  0      
  6 24  1  0      
  6 29  1  0      
  8  7  1  0      
  7  9  1  0      
  7 15  1  6      
 10  8  1  0      
  8 16  1  6      
  9 11  1  0      
 12 10  1  0      
 11 13  1  0      
 11 17  2  0      
 12 14  1  0      
 19 12  2  0      
 13 14  1  0      
 18 13  2  0      
 14 20  2  0      
 17 21  1  0      
 22 18  1  0      
 23 19  1  0      
 20 24  1  0      
 21 22  2  0      
 23 24  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
V   24 23
V   25 24
V   26 25
V   27 26
V   28 27
V   29 28
M  END
>  <Catalog Number> (1)
N1656

>  <Item Name> (1)
Schizandrin B

>  <Formula> (1)
C23H28O6

>  <MolWeight> (1)
400.46

>  <CAS Number> (1)
61281-37-6

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1656

$$$$

Untitled Document
  ChemDraw02272011112D
 20 21  0  0  0  0  0  0  0  0999 V2000
   -0.4126    1.4290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8876   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4126   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4126   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626    1.4290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0626   -1.4290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0626   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8876    1.4290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8876   -1.4290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3000    2.1435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -2.1435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  9  1  0      
  2 11  1  0      
  3  4  1  0      
  3  8  1  0      
  3  9  2  0      
  4  6  2  0      
  4 10  1  0      
  6  5  1  0      
  5 11  2  0      
  5 12  1  0      
  8  7  2  0      
  7 13  1  0      
  7 14  1  0      
 16  9  1  0      
 15 10  2  0      
 11 15  1  0      
 12 17  1  0      
 13 18  1  0      
 14 16  2  0      
 17 19  2  0      
 18 20  2  0      
M  END
>  <Catalog Number> (1)
N1672

>  <Item Name> (1)
Honokiol

>  <Formula> (1)
C18H18O2

>  <MolWeight> (1)
266.33

>  <CAS Number> (1)
35354-74-6

>  <Target> (1)
Immunology/Inflammation

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1672

$$$$

Untitled Document
  ChemDraw02272011012D
 33 36  0  0  0  0  0  0  0  0999 V2000
   -2.8578    2.2686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.2686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433    2.6811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433    0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -2.2686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.6811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.2686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.6811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.2686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.6811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.2686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.6811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.2686    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433    3.5062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5723   -1.4438    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578   -2.6811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.5062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -3.5062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0      
  2  3  2  0      
  3  4  1  0      
  4  5  2  0      
  5  6  1  0      
  6  1  2  0      
  3  7  1  0      
  7  8  2  0      
  8  9  1  0      
  9 10  1  0      
 10 11  1  0      
 11 12  1  0      
 12  7  1  0      
 10 13  2  0      
 13 14  1  0      
 14 15  2  0      
 15 16  1  0      
 16 11  2  0      
 15 17  1  0      
 17 18  1  0      
 18 19  1  0      
 19 20  1  0      
 18 21  1  0      
 21 22  1  0      
 22 23  1  0      
 23 24  1  0      
 24 19  1  0      
 22 25  1  0      
 25 26  1  0      
 27 23  1  0      
  6 28  1  0      
  9 29  2  0      
 13 30  1  0      
 14 31  1  0      
 24 32  1  0      
 25 33  2  0      
M  END
>  <Catalog Number> (1)
N1753

>  <Item Name> (1)
Scutellarin

>  <Formula> (1)
C21H18O12

>  <MolWeight> (1)
462.37

>  <CAS Number> (1)
27740-01-8

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1753

$$$$

Untitled Document
  ChemDraw02272010112D
 21 22  0  0  0  0  0  0  0  0999 V2000
    1.0323   -1.7852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2054   -1.0712    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2688    0.3588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0945   -1.0698    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0945    2.4998    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8567   -0.3559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2694   -1.0702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0317   -0.3562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8573   -1.7848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6195   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2701   -2.4991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6182   -0.3570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4433   -0.3573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8561    0.3570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6810    0.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4439    1.0716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0938    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8567    1.7859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6816    1.7855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6201   -2.4998    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0938    0.3588    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  9  1  0      
  1 10  1  0      
 10  2  1  0      
  2 12  1  0      
  6  3  1  0      
  7  4  1  0      
  5 19  1  0      
  6  7  1  0      
  6  8  1  0      
  7  9  1  0      
  8 10  1  0      
  9 11  1  0      
 12 13  1  0      
 13 14  1  0      
 14 15  2  0      
 14 16  1  0      
 15 17  1  0      
 18 16  2  0      
 17 19  2  0      
 19 18  1  0      
  1 20  1  0      
  3 21  1  0      
M  END
>  <Catalog Number> (1)
N1789

>  <Item Name> (1)
Salidroside

>  <Formula> (1)
C14H20O7

>  <MolWeight> (1)
300.3

>  <CAS Number> (1)
10338-51-9

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1789

$$$$

Untitled Document
  ChemDraw03162015572D
  0  0  0     0  0              0 V3000
M  V30 BEGIN CTAB
M  V30 COUNTS 28 32 0 0 1
M  V30 BEGIN ATOM
M  V30 1 C -2.486830 0.206250 0.000000 0
M  V30 2 C -2.486830 -0.618750 0.000000 0
M  V30 3 C -1.772359 -1.031250 0.000000 0
M  V30 4 C -1.057888 -0.618750 0.000000 0
M  V30 5 C -1.057888 0.206250 0.000000 0
M  V30 6 C -1.772359 0.618750 0.000000 0
M  V30 7 C -0.343417 -1.031250 0.000000 0
M  V30 8 C 0.371054 -0.618750 0.000000 0
M  V30 9 C 0.371054 0.206250 0.000000 0
M  V30 10 C -0.343417 0.618750 0.000000 0
M  V30 11 C 1.085525 0.618750 0.000000 0
M  V30 12 C 1.085525 1.443750 0.000000 0
M  V30 13 C 0.371054 1.856250 0.000000 0
M  V30 14 C -0.343417 1.443750 0.000000 0
M  V30 15 H -1.057888 -1.443750 0.000000 0
M  V30 16 O -0.343417 -1.856250 0.000000 0
M  V30 17 H -0.926780 1.202113 0.000000 0
M  V30 18 C -2.355722 -1.614613 0.000000 0
M  V30 19 C -1.359859 -1.745721 0.000000 0
M  V30 20 O 1.085525 -1.031250 0.000000 0
M  V30 21 C 1.167943 -0.007275 0.000000 0
M  V30 22 C 1.668888 0.860387 0.000000 0
M  V30 23 O 1.483657 -0.769476 0.000000 0
M  V30 24 C 2.486830 0.968071 0.000000 0
M  V30 25 O 1.799996 0.206250 0.000000 0
M  V30 26 C -0.495150 -0.315238 0.000000 0
M  V30 27 O -0.069429 -0.088363 0.000000 0
M  V30 28 O -1.772359 1.443750 0.000000 0
M  V30 END ATOM
M  V30 BEGIN BOND
M  V30 1 1 1 2
M  V30 2 1 2 3
M  V30 3 1 3 4
M  V30 4 1 4 5
M  V30 5 1 5 6
M  V30 6 1 6 1
M  V30 7 1 4 7
M  V30 8 1 7 8
M  V30 9 1 8 9
M  V30 10 1 9 10
M  V30 11 1 10 5
M  V30 12 1 9 11 CFG=3
M  V30 13 1 12 11 CFG=3
M  V30 14 1 12 13
M  V30 15 1 13 14
M  V30 16 1 14 10
M  V30 17 1 4 15 CFG=1
M  V30 18 1 7 16 CFG=1
M  V30 19 1 10 17 CFG=1
M  V30 20 1 3 18
M  V30 21 1 3 19
M  V30 22 1 8 20
M  V30 23 1 9 21
M  V30 24 1 12 22
M  V30 25 1 21 22
M  V30 26 2 21 23
M  V30 27 2 22 24
M  V30 28 1 11 25
M  V30 29 1 5 26 CFG=3
M  V30 30 1 26 27
M  V30 31 1 8 27 CFG=3
M  V30 32 1 6 28 CFG=3
M  V30 END BOND
M  V30 BEGIN COLLECTION
M  V30 MDLV30/STEABS ATOMS=(8 4 5 6 7 8 9 10 12)
M  V30 END COLLECTION
M  V30 END CTAB
M  END
>  <Catalog Number> (1)
N1802

>  <Item Name> (1)
Oridonin

>  <Formula> (1)
C20H28O6

>  <MolWeight> (1)
364.43

>  <CAS Number> (1)
28957-04-2

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1802

$$$$

Untitled Document
  ChemDraw02202013542D
 20 23  0  0  0  0  0  0  0  0999 V2000
   -0.3230    0.4110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9186    0.9542    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -0.2577    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1625    1.1359    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.4953    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.2577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.1548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -0.2577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.1548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.4953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9186    0.9542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.4953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435    0.1548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.3203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    2.3203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  1  0      
  6  1  1  0      
 10  2  1  0      
  2 15  1  0      
  3 10  1  0      
  3 18  1  0      
 15  4  1  0      
  5 18  2  0      
  6  7  1  0      
  6  8  1  0      
  6 10  1  0      
  7  9  1  0      
  7 12  1  0      
  8 11  1  0      
  8 14  1  0      
  9 13  1  0      
  9 17  1  0      
 11 13  1  0      
 12 16  1  0      
 14 18  1  0      
 14 19  1  0      
 15 16  1  0      
 15 20  1  0      
M  END
>  <Catalog Number> (1)
N1827

>  <Item Name> (1)
Artemisinine

>  <Formula> (1)
C15H22O5

>  <MolWeight> (1)
282.33

>  <CAS Number> (1)
63968-64-9

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1827

$$$$

Untitled Document
  ChemDraw02272010062D
 20 22  0  0  0  0  0  0  0  0999 V2000
    0.7143    1.2010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8257    2.5282    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3973   -0.0540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4181    0.7706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0104    0.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7142    1.2371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6726   -0.4484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0312   -0.0181    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6934    2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4389    0.8428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3973    2.4921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426    1.2731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1218    2.0977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1427    1.1650    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6518   -1.2731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3557   -1.7035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0802   -1.3092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1010   -0.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8257   -0.0901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3349   -2.5282    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  1  0      
  5  1  2  0      
  2 13  1  0      
  4  3  1  0      
  7  3  1  0      
  5  6  1  0      
  8  5  1  0      
  6  9  1  0      
  6 10  2  0      
  7  8  1  0      
  9 11  2  0      
 12 10  1  0      
 11 13  1  0      
 13 12  2  0      
  4 14  2  0      
  7 15  2  0      
 15 16  1  0      
 16 17  2  0      
 17 18  1  0      
 18  3  2  0      
 18 19  1  0      
 16 20  1  0      
M  END
>  <Catalog Number> (1)
N1828

>  <Item Name> (1)
Apigenin

>  <Formula> (1)
C15H10O5

>  <MolWeight> (1)
270.24

>  <CAS Number> (1)
520-36-5

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1828

$$$$

Untitled Document
  ChemDraw07031416592D
 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.4125    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.8579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    2.1434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0625   -2.8579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0625   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  9  1  0      
 10  1  1  0      
  2 12  1  0      
  3 14  1  0      
  4 13  2  0      
  5 16  1  0      
  6 20  1  0      
  7 22  1  0      
  9  8  1  0      
 13  8  1  0      
  8 14  2  0      
  9 15  2  0      
 10 11  1  0      
 12 10  2  0      
 11 17  1  0      
 11 19  2  0      
 13 12  1  0      
 14 18  1  0      
 16 15  1  0      
 18 16  2  0      
 17 20  2  0      
 21 19  1  0      
 20 22  1  0      
 22 21  2  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
M  END
>  <Catalog Number> (1)
N1841

>  <Item Name> (1)
Quercetin

>  <Formula> (1)
C15H10O7

>  <MolWeight> (1)
302.24

>  <CAS Number> (1)
117-39-5

>  <Target> (1)
PI3K/Akt/mTOR Signaling

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1841

$$$$

Untitled Document
  ChemDraw11151816512D
 23 25  0  0  0  0  0  0  0  0999 V2000
    0.3573    0.2063    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0718   -1.4437    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3573   -2.2687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -2.2687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    2.2687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2152   -0.2063    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2152    0.2063    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2152    1.4437    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3573   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3573   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0718    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3573   -1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0718   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0718   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0718    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    1.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5007    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5007   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5007   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5007    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  9  1  0      
  1 14  1  0      
  3 12  2  0      
  4 17  1  0      
  5 19  1  0      
  6 20  1  0      
  7 22  1  0      
  8 23  1  0      
  9 10  1  0      
 10 12  1  0      
 11 15  1  0      
 11 16  2  0      
 12 13  1  0      
 13 14  1  0      
 13 17  2  0      
 14 18  2  0      
 15 20  2  0      
 19 16  1  0      
 17 21  1  0      
 18 22  1  0      
 23 19  2  0      
 20 23  1  0      
 21 22  2  0      
  9 11  1  0      
 10  2  1  0      
V    1 0
V    2 1
V    3 2
V    4 3
V    5 4
V    6 5
V    7 6
V    8 7
V    9 8
V   10 9
V   11 10
V   12 11
V   13 12
V   14 13
V   15 14
V   16 15
V   17 16
V   18 17
V   19 18
V   20 19
V   21 20
V   22 21
V   23 22
M  END
>  <Catalog Number> (1)
N1849

>  <Item Name> (1)
Dihydromyricetin

>  <Formula> (1)
C15H12O8

>  <MolWeight> (1)
320.25

>  <CAS Number> (1)
27200-12-0

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1849

$$$$

Untitled Document
  ChemDraw02282010122D
 19 21  0  0  0  0  0  0  0  0999 V2000
   -0.3572    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0      
  2  3  1  0      
  3  4  2  0      
  4  5  1  0      
  5  6  2  0      
  6  7  1  0      
  7  8  2  0      
  3  8  1  0      
  8  9  1  0      
  4 10  1  0      
 10 11  1  0      
 11 12  2  0      
 12 13  1  0      
 13 14  1  0      
 13 15  2  0      
 15 16  1  0      
 16 17  1  0      
 16 18  2  0      
  2 18  1  0      
 11 18  1  0      
 10 19  2  0      
M  END
>  <Catalog Number> (1)
N1852

>  <Item Name> (1)
Chrysophanol

>  <Formula> (1)
C15H10O4

>  <MolWeight> (1)
254.23

>  <CAS Number> (1)
481-74-3

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1852

$$$$

Untitled Document
  ChemDraw02202010322D
 31 36  0  0  0  0  0  0  0  0999 V2000
    0.5400    1.3004    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8700   -0.7582    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0325    0.8154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0326    0.0308    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6949    1.6084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5400   -1.2879    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5400   -2.0726    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6171    0.6204    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0804   -0.2269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0804    1.0730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1274    0.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9525    0.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1274    0.8154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1274   -0.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2075   -0.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9525    0.8154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5400   -0.4542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2075    0.8154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5400   -1.2389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2075    0.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6200   -0.4542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8700    0.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6200    1.3004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2874    0.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2874    0.8154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6200    2.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7908   -1.3372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5773   -2.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5877   -1.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3742   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4065   -1.2510    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1 13  1  0      
  1 18  1  0      
  2 14  1  0      
  2 22  1  0      
  3 18  1  0      
  3 24  1  0      
  4 20  1  0      
  4 25  1  0      
  5 16  1  0      
  6 17  1  0      
  7 19  1  0      
  8 22  2  0      
  9 24  2  0      
 10 25  2  0      
 11 12  1  0      
 11 13  1  0      
 11 14  1  0      
 11 17  1  0      
 12 15  1  0      
 12 18  1  0      
 12 21  1  0      
 13 16  1  0      
 13 22  1  0      
 14 19  1  0      
 15 19  1  0      
 16 20  1  0      
 16 23  1  0      
 17 20  1  0      
 21 24  1  0      
 23 25  1  0      
 23 26  1  0      
 15 27  1  0      
 27 28  1  0      
 27 29  1  0      
 27 30  1  0      
 21 31  1  0      
M  END
>  <Catalog Number> (1)
N1908

>  <Item Name> (1)
Ginkgolide C

>  <Formula> (1)
C20H24O11

>  <MolWeight> (1)
440.4

>  <CAS Number> (1)
15291-76-6

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N1908

$$$$

Untitled Document
  ChemDraw02262016322D
 41 45  0  0  0  0  0  0  0  0999 V2000
   -1.0296    1.7952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521    3.2121    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2182    3.9325    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7385    2.5275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    1.0708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2044    1.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4452    1.7832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2046    1.7912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2113    2.5037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4386    2.5115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0362    2.4997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0227    3.2240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1977    3.2200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2636    2.5155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6796    1.8030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6727    3.2320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5044    1.8071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4977    3.2359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9135    2.5235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4385    0.3544    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2635    0.3544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6760   -0.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5010   -0.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9135    0.3544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5010    1.0688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6760    1.0688    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9135    1.7833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9135   -1.0746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2635   -1.0746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6760   -1.7890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2635   -2.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6760   -3.2180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5010   -3.2180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9135   -2.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5010   -1.7890    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4385   -2.5035    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7385   -2.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2635   -3.9325    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9135   -3.9325    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7385    0.3544    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7385    1.7833    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  8  1  0      
  1 10  1  0      
  2 11  1  0      
  3 13  2  0      
  4 19  1  0      
  5  6  1  0      
  5  7  2  0      
  6  8  2  0      
  7 11  1  0      
  8  9  1  0      
  9 11  2  0      
  9 13  1  0      
 10 12  1  0      
 10 14  1  6      
 12 13  1  0      
 14 15  1  0      
 14 16  2  0      
 15 17  2  0      
 18 16  1  0      
 17 19  1  0      
 19 18  2  0      
  5 20  1  0      
 21 20  1  6      
 21 22  1  0      
 22 23  1  0      
 23 24  1  0      
 24 25  1  0      
 25 26  1  0      
 26 21  1  0      
 25 27  1  6      
 23 28  1  6      
 22 29  1  1      
 30 29  1  6      
 30 31  1  0      
 31 32  1  0      
 32 33  1  0      
 33 34  1  0      
 34 35  1  0      
 35 30  1  0      
 31 36  1  1      
 34 37  1  1      
 32 38  1  1      
 33 39  1  6      
 24 40  1  1      
 27 41  1  0      
V    1 1
V    5 7
V    6 8
V    7 6
V    8 8a
V    9 4a
V   10 2
V   11 5
V   12 3
V   13 4
V   14 1
V   15 2
V   16 6
V   17 3
V   18 5
V   19 4
V   21 2
V   22 3
V   23 4
V   24 5
V   25 6
V   26 1
V   27 1
V   30 2
V   31 3
V   32 4
V   33 5
V   34 6
V   35 1
M  END
>  <Catalog Number> (1)
N2371

>  <Item Name> (1)
Naringin

>  <Formula> (1)
C27H32O14

>  <MolWeight> (1)
580.53

>  <CAS Number> (1)
10236-47-2

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N2371

$$$$

Untitled Document
  ChemDraw02272009112D
 44 48  0  0  0  0  0  0  0  0999 V2000
   -1.0819   -0.6487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4022    1.4256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5106   -0.6727    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5245    0.1522    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3330    0.2002    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5522    1.8021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0542   -2.2985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4691   -3.1472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9117   -2.3464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8587    3.0513    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4691    0.6487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3053    1.8501    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9989    3.0992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8564    3.1472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2320   -2.2265    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8172   -3.0753    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0958    0.1762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8171    0.5767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8310    1.4016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7894   -1.0731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3883    0.6007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7756   -1.8981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1235    1.8261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4829   -2.3224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2042   -1.9221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2181   -1.0970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1374    2.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9394   -0.6967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0405    0.6247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7618    0.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0266    1.4496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7341    1.8741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7756   -0.6007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4553    1.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7202    2.6989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1628    1.8981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4968   -1.0011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0682   -1.0251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4276    3.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1489    2.7229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5107   -1.8261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0820   -1.8501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8033   -2.2505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9394   -1.8020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 17  1  1  6      
 20  1  1  6      
  2 21  1  0      
  2 23  1  0      
  3 20  1  0      
  3 26  1  0      
 18  4  1  1      
 21  5  1  6      
  5 29  1  0      
 19  6  1  6      
 22  7  1  6      
 24  8  1  6      
 25  9  1  1      
 10 27  1  0      
 30 11  1  0      
 11 34  1  0      
 12 31  2  0      
 13 35  1  0      
 14 40  1  0      
 15 41  1  0      
 16 43  1  0      
 17 18  1  0      
 17 21  1  0      
 18 19  1  0      
 19 23  1  0      
 20 22  1  0      
 22 24  1  0      
 23 27  1  1      
 24 25  1  0      
 25 26  1  0      
 26 28  1  6      
 29 30  2  0      
 31 29  1  0      
 30 33  1  0      
 31 32  1  0      
 34 32  1  0      
 32 35  2  0      
 33 37  1  0      
 33 38  2  0      
 34 36  2  0      
 35 39  1  0      
 40 36  1  0      
 37 41  2  0      
 42 38  1  0      
 39 40  2  0      
 41 43  1  0      
 43 42  2  0      
 15 44  1  0      
V    2 1
V    3 1
V   11 1
V   17 3
V   18 4
V   19 5
V   20 2
V   21 2
V   22 3
V   23 6
V   24 4
V   25 5
V   26 6
V   27 1
V   29 3
V   30 2
V   31 4
V   32 4a
V   33 1
V   34 8a
V   35 5
V   36 8
V   37 2
V   38 6
V   39 6
V   40 7
V   41 3
V   42 5
V   43 4
M  END
>  <Catalog Number> (1)
N2516

>  <Item Name> (1)
Isorhamnetin-3-O-neohespeidoside

>  <Formula> (1)
C28H32O16

>  <MolWeight> (1)
624.55

>  <CAS Number> (1)
55033-90-4

>  <Target> (1)
Natural Products

>  <URL> (1)
http://www.apexbt.com/search.php?catalog=N2516

$$$$

