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Docetaxel Microtubulin disassembly inhibitor

Catalog No.A4394
Size Price Stock Qty
10mM (in 1mL DMSO)
$70.00
In stock
50mg
$50.00
In stock
100mg
$60.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Sample solution is provided at 25 µL, 10mM.

Product Citations

1. Zhou XW, Xia YZ, et al. "Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling. Oncotarget." 2017 Oct 19;8(60):101965-101983. PMID:29254218

Quality Control

Chemical structure

Docetaxel

Related Biological Data

Docetaxel

Related Biological Data

Docetaxel

Related Biological Data

Docetaxel

Biological Activity

Description Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets Microtubules          
IC50            

Protocol

Cell experiment [1]:

Cell lines

Nine human gastric cancer cell lines

Preparation method

The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 °C for several months.

Reaction Conditions

< 0.00012 ~ > 1.2 μM

Applications

The cytotoxic effect of Docetaxel was relatively greater than that of Paclitaxel in six of the nine cells. The effect of Docetaxel and Paclitaxel on MM-7 and ST-SA-I cells was less than on the other seven cultured cells.

Animal experiment [1]:

Animal models

Mice bearing human gastric cancer xenografts (MKN-28, MKN-45 and KKLS)

Dosage form

3.75, 7.5, 15 or 22 mg/kg; i.v.; three times within a 4-day interval

Applications

Docetaxel dose-dependently inhibited tumour growth. At the doses of 15 and 22 mg/kg, Docetaxel induced complete tumor regression in all mice.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Tanaka M, Obata T, Sasaki T. Evaluation of antitumour effects of docetaxel (Taxotere) on human gastric cancers in vitro and in vivo. Eur J Cancer. 1996 Feb;32A(2):226-30.

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Chemical Properties

Cas No. 114977-28-5 SDF Download SDF
Synonyms Taxotere, Docetaxel anhydrous, Trihydrate
Chemical Name N/A
Canonical SMILES O=C(N[[email protected]]([[email protected]](C(O[[email protected]]1C[[email protected]]2(O)C(C)(C)C([[email protected]@H](O)C([[email protected]@]3(C)[[email protected]]([[email protected]@](CO4)(OC(C)=O)[[email protected]@]4([H])C[[email protected]@H]3O)([H])[[email protected]@H]2OC(C5=CC=CC=C5)=O)=O)=C1C)=O)O)C6=CC=CC=C6)OC(C)(C)C
Formula C43H53NO14 M.Wt 807.88
Solubility >40.4mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Docetaxel, a new taxoid family member originally derived from the needles of the European Yew tree Taxus baccata, is a potent chemotherapeutic agent that acts as a spindle poison to inhibit microtubule dynamics and cell cycle arrest through promoting microtublin assembly and stabilizing the polymers against depolymerization. Docetaxel has demonstrated strong in vivo and in vitro antitumor activities against a broad range of cancers including breast, lung, ovarian, head and neck, and gastric cancers. Previous studies have shown that docetaxel exertss stronger cytotoxicity than other chemotherapeutic agents against ovarian carcinoma cell lines, in which the cytotoxicity of docetaxel is 1.2-2.6 times greater than that of paclitaxel and over 1000 times greater than that of cisplatin or etoposide.

Reference

N Katsumata. Docetaxel: an alternative taxane in ovarian cancer. British Journal of Cancer (2003) 89 (Suppl 3), S9-S15