• We specialize in small molecule inhibitors, agonists, antagonists and screening libraries!
Search Site
Home >> Screening Panel >> DiscoveryProbe™ Membrane Transporter/Ion Channel-related Compounds Panel
Related Products
DiscoveryProbe™ Membrane Transporter/Ion Channel-related Compounds Panel

DiscoveryProbe™ Membrane Transporter/Ion Channel-related Compounds Panel

Catalog No. L1012
Size Price Stock Qty
5mg/well $2,670.00 In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Click and Customize the Panel with your own choices of compounds/size/quantities/chemical forms etc.

HTS Facility Partners

Featured Products of the Panel

Catalog No. Product Name Summary Targets CAS Number Smiles
A8455 Nilvadipine Potent calcium channel blocker Membrane Transporter/Ion Channel|Calcium Channel 75530-68-6 CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C
A8351 VX-809 CFTR corrector Membrane Transporter/Ion Channel|CFTR 936727-05-8 CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
A1855 Bumetanide Inhibitor of Na+/K+/Cl- cotransporter Membrane Transporter/Ion Channel|NKCC 28395-03-1 CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
A3100 (+)-MK 801 Potent NMDA antagonist Membrane Transporter/Ion Channel|NMDA Receptor 70449-94-4 C[C@]1(N2)C3=C(C=CC=C3)C[C@@H]2C4=C1C=CC=C4
A3532 KN-93 CaMKII inhibitor,selective and competitive Membrane Transporter/Ion Channel|P2X purinergic receptor 139298-40-1 CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
B7659 Psora 4 Potent KV1.3 channel blocker Membrane Transporter/Ion Channel|Potassium Channel 724709-68-6 O=C1OC2=C(C=C1)C(OCCCCC3=CC=CC=C3)=C4C(OC=C4)=C2
B4798 Procainamide HCl Na+ channel blocker; DNA methyltransferase 1 inhibitor Membrane Transporter/Ion Channel|Sodium Channel 614-39-1 CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl
A8519 SB705498 TRPV1 antagonist,potent and selective Membrane Transporter/Ion Channel|TRPV1 501951-42-4 C1CN(CC1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F
Download the Membrane Transporter-related Compounds Panel - XLSX       Download the Membrane Transporter-related Compounds Panel - SDF

Quality Control

Related Biological Data

VX-809

Related Biological Data

Ivacaftor
Ivacaftor inhibits mutant CFTR.

Related Biological Data

VX-809

Signaling Pathway

Sodium Channel Compare Products
Potassium Channel Compare Products
Calcium Channel Compare Products

Advantages

  • Available in stock with overnight delivery and free shipping over $500
  • Cost-effective and competitive price to save your findings
  • Potent, selective and cell-permeable in inhibiting or activating target molecules
  • Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
  • Detailed files describing potency, selectivity and applications etc.
  • Supported by published data from top peer-reviewed journals
  • Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility Soluble in DMSO Storage Desiccate at -20°C
Packaging 96 well plate Form Powder
General tips For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to membrane transporter/ion channel, including ATPase, calcium channel and CFTR etc. Facilitate your research towards the insights of heart diseases, cystic fibrosis and immune disorders etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29.
Abstract
Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
2. Sajja RK, Cucullo L. Altered glycaemia differentially modulates efflux transporter expression and activity in hCMEC/D3 cell line. Neurosci Lett. 2015 Jun 26;598:59-65.
Abstract
The impact of diabetes on BBB efflux transporters is less understood. In this study, we examined the effects of single or repeated episodes of hypo-and hyperglycemia on major BBB efflux transporters expression/function in human cerebromicrovascular endothelial cell line (hCMEC/D3). this study suggests a differential impact of altered glycemic conditions on major BBB drug efflux transporters expression/function, sensitive to the length of exposure (acute vs. repeated), with an implication for altered CNS drug disposition in diabetic population.