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DiscoveryProbe™ Chromatin/Epigenetics-related Compounds Panel

In stock
Catalog No.
L1006
 
Grouped product items
SizePriceStock Qty
5mg/well
$7,980.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

A wide range of well-characterized bioactive molecules that covers various targets related to chromatin/epigenetics, including bromodomain, aurora kinase, JAK, PARP and Pim etc. Facilitate your research towards the insights of histone modification, gene expression regulation, genetic disorders and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.

Quality Control

Related Biological Data

JQ1

Related Biological Data

JQ1

Related Biological Data

JQ1

Related Biological Data

JQ1

Related Biological Data

Barasertib (AZD1152-HQPA)

Related Biological Data

EPZ005687
 

Advantages

Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation

Featured Products of the Panel

Catalog No. Product Name Summary Targets CAS Number Smiles
A4112 Barasertib (AZD1152-HQPA) Aurora Kinase B inhibitor, Potent and selective Chromatin/Epigenetics|Aurora Kinase 722544-51-6 CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
B1012 MS436 BRD4 inhibitor Chromatin/Epigenetics|Bromodomain 1395084-25-9 CC1=CC(=NNC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3)C(=CC1=O)N
A1906 Decitabine (NSC127716, 5AZA-CdR) Deoxycytidine analog and cellular diifferentiation inducer Chromatin/Epigenetics|DNA Methyltransferase 2353-33-5 C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
A1912 Lomeguatrib MGMT inhibitor Chromatin/Epigenetics|DNA Methyltransferase 192441-08-0 C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
A4170 EPZ004777 DOT1L inhibitor Chromatin/Epigenetics|Histone Methyltransferase 1338466-77-5 CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O
A3012 Ruxolitinib (INCB018424) Poten JAK1/2 inhibitor Chromatin/Epigenetics|JAK 941678-49-5 C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
A4154 Olaparib (AZD2281, Ku-0059436) Potent PARP1/PARP2 inhibitor Chromatin/Epigenetics|PARP 763113-22-0 C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
A3962 AZD1208 PIM kinase inhibitor Chromatin/Epigenetics|Pim 1204144-28-4 C1CC(CN(C1)C2=C(C=CC=C2C=C3C(=O)NC(=O)S3)C4=CC=CC=C4)N
Download the Chromatin/Epigenetics-related Compounds Panel - XLSX       Download the Chromatin/Epigenetics-related Compounds Panel - SDF

References

1. Chen ZX, Riggs AD. DNA methylation and demethylation in mammals. J Biol Chem. 2011 May 27;286(21):18347-53.
Abstract
Understanding how these patterns of 5-methylcytosine are established and maintained requires the elucidation of mechanisms for both DNA methylation and demethylation. Important remaining challenges are to understand how DNA methylation systems function in vivo and in the context of chromatin. In addition, the enzymes and mechanisms for demethylation remain to be elucidated, recent studies implicate base excision repair for genome-wide DNA demethylation in germ cells and early embryos.
2. Korb E, Herre M, Zucker-Scharff I, Darnell RB, Allis CD. BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice. Nat Neurosci. 2015 Oct;18(10):1464-73.
Abstract
Brd4 is a member of the BET protein family, which binds acetylated histones and has a critical role in numerous cell types in regulating transcription. JQ1, a small molecule BET inhibitor, yet almost nothing is known about Brd4 function in the brain. Here we show that Brd4 is a key player in neuronal function and mediates the transcriptional regulation underlying learning and memory. The loss of Brd4 function affects critical synaptic proteins. Brd4 provides a critical link between neuronal activation and the transcriptional responses that occur during memory formation.