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Deferoxamine mesylate iron-chelating agent

Catalog No.B6068
Size Price Stock Qty
100mg
$50.00
In stock
500mg
$80.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

Deferoxamine mesylate

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Chemical Properties

Cas No. 138-14-7 SDF Download SDF
Chemical Name (Z)-4-((5-aminopentyl)(hydroxy)amino)-N-(5-((Z)-N,4-dihydroxy-4-((5-(N-hydroxyacetamido)pentyl)imino)butanamido)pentyl)-4-oxobutanimidic acid compound with methanesulfonic acid (1:1)
Canonical SMILES CC(N(O)CCCCC/N=C(O)/CCC(N(O)CCCCC/N=C(O)/CCC(N(O)CCCCCN)=O)=O)=O.CS(O)(=O)=O
Formula C26H52N6O11S M.Wt 656.79
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Deferoxamine mesylate is a specific iron-chelating agent [1][2][3]

Deferoxamine mesylate can be used for treating acute iron intoxication. Deferoxamine complexed with iron to form ferrioxamine and then prevented the iron from entering into further chemical reactions. The formed chelate is readily soluble in water and passes easily through the kidney [1].

In Fisher rats transplanted with the 13762NF mammary adenocarcinoma, deferoxamine mesylate reduced rat tumor growth. While deferoxamine mesylate?injections plus a low iron diet caused the greatest inhibitory effect on tumor growth. Deferoxamine mesylate may be a useful chemotherapeutic agent in the treatment of breast cancer [2]. In Sprague-Dawley rats, injected with deferoxamine mesylate (75-90 mg; 300 mg/kg) via the celiac artery before surgery. Deferoxamine mesylate signi?cantly lowered the serum levels of amylase, lipase, and malondialdehyde (MDA) after orthotopic liver autotransplantation. Deferoxamine mesylate also protected pancreatic tissue through up-regulated expression of HIF-1 protein and inhibition of oxidative toxic reactions [3].

References:
Deferoxamine mesylate (Desferal mesylate).  A specific iron-chelating agent for treating acute iron intoxication. Clin Pharmacol Ther. 1969 Jul-Aug;10(4):595-6.
Wang F, Elliott RL, Head JF.  Inhibitory effect of deferoxamine mesylate and low iron diet on the 13762NF rat mammary adenocarcinoma. Anticancer Res. 1999 Jan-Feb;19(1A):445-50.
Li Y, Zhang PJ, Jin C, et al.  Protective effects of deferoxamine mesylate preconditioning on pancreatic tissue in orthotopic liver autotransplantation in rats. Transplant Proc. 2011 Jun;43(5):1450-5.