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D-64131Tubulin polymerization inhibitor

D-64131

Catalog No. A3344
Size Price Stock
10mg Please Inquire Please Inquire
50mg Please Inquire Please Inquire

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 74588-78-6 SDF
Synonyms D 64131;D64131
Chemical Name (5-methoxy-1H-indol-2-yl)-phenylmethanone
Canonical SMILES COC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3
Formula C16H13NO2 M.Wt 251.28
Solubility Soluble in DMSO > 10 mM Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. [1]

The polymerization of bovine brain tubulin as well as binding of [3H] colchicine to biotinylated αβ-tubulin was dose-dependently inhibited by D-64131. Many cancer cells display abnormal microtubule structures, such as fragmented mitotic spindles or multiple spindle poles after treatment with D-64131. Nuclear blebbing and abnormal nuclear structures typical for apoptotic cells are detectable in many cells treated with D-64131. In nude mice, D-64131 proved to be well tolerated and highly active against the human amelanoic melanoma MEXF 989 tumor xenograft. D-64131 treatment resulted in significant tumor growth inhibition during treatment. [1]

Reference:
1. Beckers T, Reissmann T, Schmidt M et al.  2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 Jun 1;62(11):3113-9.