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D-64131

D-64131

Catalog No. A3344
Size Price Stock
10mg Please Inquiry Please Inquiry
50mg Please Inquiry Please Inquiry

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Sample solution is provided at 25 µL, 10mM.

D-64131 Dilution Calculator

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Chemical Properties

Cas No. 74588-78-6 SDF
Synonyms D 64131;D64131
Chemical Name (5-methoxy-1H-indol-2-yl)-phenylmethanone
Canonical SMILES COC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3
Formula C16H13NO2 M.Wt 251.28
Solubility DMSO 100 mM Ethanol 20 mM Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin. D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). D-64131 prevents growth of tumor models in mice following oral administration in vivo. D-64131 has significant potential in cancer treatment.