Sample solution is provided at 25 µL, 10mM.
Publications citing ApexBio Products
Related Compound Libraries
|Cas No.||1439934-41-4||SDF||Download SDF|
|Chemical Name||(Z)-2-((E)-(5-chloro-2-((4-(piperazin-1-yl)phenyl)amino)pyrimidin-4(3H)-ylidene)amino)-N-methylbenzimidic acid|
|Solubility||>21.9mg/mL in DMSO||Storage||Store at -20°C|
CTx-0294885 is a novel bisanilino pyrimidine. It has inhibitory activity towards a wild range of kinases in vitro. CTx-0294885 is capable of capturing more than half of the expressed kinome in MDA-MB-231 cells. Large-scale CTx-0294885-based affinity purification with LC−MS/MS identifies 235 protein kinases. CTx-0294885 binds additional kinases that were not identified from previous studies using other kinase capture reagents. It is further developed into a Sepharose-supported kinase capture reagent. CTx-0294885 is a new tool for analysis of kinome signaling networks. 
1. Zhang L, Holmes IP, Hochgräfe F et al. Characterization of the novel broad-spectrum
kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based
kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16.