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CTX0294885Pan-kinase inhibitor

CTX0294885

Catalog No. B5843
Size Price Stock Qty
5mg $110.00 In stock
10mg $180.00 In stock
50mg $550.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

CTX0294885

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Chemical Properties

Cas No. 1439934-41-4 SDF Download SDF
Chemical Name (Z)-2-((E)-(5-chloro-2-((4-(piperazin-1-yl)phenyl)amino)pyrimidin-4(3H)-ylidene)amino)-N-methylbenzimidic acid
Canonical SMILES C/N=C(O)/C1=CC=CC=C1/N=C(N2)\C(Cl)=CN=C2NC3=CC=C(N4CCNCC4)C=C3
Formula C22H24ClN7O M.Wt 437.93
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

CTx-0294885 is a novel bisanilino pyrimidine. It has inhibitory activity towards a wild range of kinases in vitro. CTx-0294885 is capable of capturing more than half of the expressed kinome in MDA-MB-231 cells. Large-scale CTx-0294885-based affinity purification with LC−MS/MS identifies 235 protein kinases. CTx-0294885 binds additional kinases that were not identified from previous studies using other kinase capture reagents. It is further developed into a Sepharose-supported kinase capture reagent. CTx-0294885 is a new tool for analysis of kinome signaling networks. [1]

Reference:
1.  Zhang L, Holmes IP, Hochgräfe F et al. Characterization of the novel broad-spectrum
kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based
kinome profiling.  J Proteome Res. 2013 Jul 5;12(7):3104-16.