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Prothrombin (474-477) [Mus musculus]
Role in coagulation cascade

Prothrombin (474-477) [Mus musculus]

Catalog No. A1058
Size Price Stock Qty
1mg $40.00 In stock
5mg $120.00 In stock
10mg $200.00 In stock
25mg $280.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Coagulation factor II peptide; prothrombin (474-477) [Mus musculus]

Prothrombin (474-477) [Mus musculus] Dilution Calculator

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Prothrombin (474-477) [Mus musculus] Molarity Calculator

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Chemical Properties

Cas No. SDF Download SDF
Synonyms H2N-Tyr-Ile-His-Pro-OH
Canonical SMILES OC1=CC=C(C[C@H](N)C(N[C@@H]([C@H](C)CC)C(NC(CC2=CNC=N2)C(N3CCC[C@]3([H])C(O)=O)=O)=O)=O)C=C1
Formula C26H36N6O6 M.Wt 528.6
Solubility Storage Store at -20°C
General tips N/A
Shipping Condition N/A

Background

Prothrombin (coagulation factor II) (H2N-Tyr-Ile-His-Pro-OH) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid (Gla).

Prothrombin is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the stemming of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. [1]

Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin have been described (e.g., hypoprothrombinemia). Anti-prothrombin antibodies in autoimmune disease may be a factor in the formation of the lupus anticoagulant, also known as antiphospholipid syndrome. Hyperprothrombinemia can be caused by the G20210A mutation. Thus, manipulation of prothrombin is central to the mode of action of most anticoagulants.

A1058_1

Ref:

1. Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somat. Cell Mol. Genet. 13 (3): 285–92.