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Catalog No.
AMPA/kainate receptor antagonist
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CNQX is a potent and competitive antagonist for AMPA/kainate receptors. 

Superfusion of hippocampal slices and CNQX (2-5 μM) reversibly blocks Schaffer collaterals and mossy fiber excitatory post-synaptic potentials (EPSP), and also retains fast and slow GABA-mediated inhibitory effects[1]. 

Ten minutes before the test, CNQX (0.5 or 1.25 μg) is bilaterally infused into the amygdala or dorsal hippocampus, which partially prevented the expression of hypotensive avoidance in rats at 24 h after training. At a dose of 0.5 μg, CNQX causes complete blockade[2]. 


[1]. Neuman R S, Ben-Ari Y, Gho M, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neuroscience Letters, 1988, 92(1): 64-68.

[2]. Kim M, Campeau S, Falls W A, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol, 1993, 59(1): 5-8.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
Cas No.115066-14-3
Solubility≥23.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Chemical Name7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile
SDFDownload SDF
Canonical SMILESO=C1NC2=CC([N+]([O-])=O)=C(C#N)C=C2NC1=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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Chemical structure


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